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[Effects of tea on DMBA-induced oral carcinogenesis in hamsters].
Wei Sheng Yan Jiu. 1999 Sep 30; 28(5):289-92.WS

Abstract

The preventive effects of green tea, tea pigments and mixed tea (a composite of whole water extract from green tea, tea polyphenols, and tea pigments) on 7, 12-dimethylbenz(a) anthracene(DMBA)-induced oral carcinogenesis in golden Syrian hamsters were studied. The hamsters were divided into five groups. i.e. the positive control group(the right buccal pouches of animal was topically treated with 0.5% DMBA in acetone three times per week for 15 weeks), three tea treated groups(1.5% green tea, 0.1% tea pigments and 0.5% mixed tea as the sole source of drinking water from two weeks before starting the DMBA treatment to the end of the experiment) and the negative control group(acetone applied topically). The results showed that in the 1.5% green tea, 0.1% tea pigments and 0.5% mixed tea groups, the inhibitory rates of the average number of tumor per hamster were 42.6%, 50.8% and 67.2% respectively, and the mean tumor burdens were 79% 89% and 95% respectively, compared with the positive control group. In the three tea groups, the frequency of micronucleated cells, the number of silver-stained nucleolar organizer regions (AgNOR), labeling index of proliferating cell nuclear antigen(PCNA) and the level of epidermal growth factor receptor(EGFR) expression in the oral mucosa cells were also less than those in the positive control group. These results clearly indicated that the mixed tea could effectively inhibit DMBA-induced oral carcinogenesis in hamsters. The mixed tea was more effective than green tea or tea pigments in this animal model. Protection of DNA from damage by carcinogen and suppression of cell proliferation was considered as important mechanisms of the anticarcinogenic effects of the mixed tea preparations.

Authors+Show Affiliations

Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12712700

Citation

Li, N, et al. "[Effects of Tea On DMBA-induced Oral Carcinogenesis in Hamsters]." Wei Sheng Yan Jiu = Journal of Hygiene Research, vol. 28, no. 5, 1999, pp. 289-92.
Li N, Han C, Chen J. [Effects of tea on DMBA-induced oral carcinogenesis in hamsters]. Wei Sheng Yan Jiu. 1999;28(5):289-92.
Li, N., Han, C., & Chen, J. (1999). [Effects of tea on DMBA-induced oral carcinogenesis in hamsters]. Wei Sheng Yan Jiu = Journal of Hygiene Research, 28(5), 289-92.
Li N, Han C, Chen J. [Effects of Tea On DMBA-induced Oral Carcinogenesis in Hamsters]. Wei Sheng Yan Jiu. 1999 Sep 30;28(5):289-92. PubMed PMID: 12712700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of tea on DMBA-induced oral carcinogenesis in hamsters]. AU - Li,N, AU - Han,C, AU - Chen,J, PY - 2003/4/26/pubmed PY - 2003/6/24/medline PY - 2003/4/26/entrez SP - 289 EP - 92 JF - Wei sheng yan jiu = Journal of hygiene research JO - Wei Sheng Yan Jiu VL - 28 IS - 5 N2 - The preventive effects of green tea, tea pigments and mixed tea (a composite of whole water extract from green tea, tea polyphenols, and tea pigments) on 7, 12-dimethylbenz(a) anthracene(DMBA)-induced oral carcinogenesis in golden Syrian hamsters were studied. The hamsters were divided into five groups. i.e. the positive control group(the right buccal pouches of animal was topically treated with 0.5% DMBA in acetone three times per week for 15 weeks), three tea treated groups(1.5% green tea, 0.1% tea pigments and 0.5% mixed tea as the sole source of drinking water from two weeks before starting the DMBA treatment to the end of the experiment) and the negative control group(acetone applied topically). The results showed that in the 1.5% green tea, 0.1% tea pigments and 0.5% mixed tea groups, the inhibitory rates of the average number of tumor per hamster were 42.6%, 50.8% and 67.2% respectively, and the mean tumor burdens were 79% 89% and 95% respectively, compared with the positive control group. In the three tea groups, the frequency of micronucleated cells, the number of silver-stained nucleolar organizer regions (AgNOR), labeling index of proliferating cell nuclear antigen(PCNA) and the level of epidermal growth factor receptor(EGFR) expression in the oral mucosa cells were also less than those in the positive control group. These results clearly indicated that the mixed tea could effectively inhibit DMBA-induced oral carcinogenesis in hamsters. The mixed tea was more effective than green tea or tea pigments in this animal model. Protection of DNA from damage by carcinogen and suppression of cell proliferation was considered as important mechanisms of the anticarcinogenic effects of the mixed tea preparations. SN - 1000-8020 UR - https://www.unboundmedicine.com/medline/citation/12712700/[Effects_of_tea_on_DMBA_induced_oral_carcinogenesis_in_hamsters]_ L2 - https://medlineplus.gov/oralcancer.html DB - PRIME DP - Unbound Medicine ER -