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Adipocyte-derived hormone levels in HIV lipodystrophy.
Antivir Ther 2003; 8(1):9-15AT

Abstract

OBJECTIVE

Despite evidence for the role of adipocyte-derived hormones in insulin resistance, little is known about their levels in human lipodystrophic states. We examined the relationships of plasma leptin and adiponectin levels to fat distribution and insulin sensitivity in the HIV lipodystrophy syndrome.

DESIGN

Cross-sectional study

SETTING

HIV primary care practices

PATIENTS

HIV-infected men with (n=13) and without (12) lipodystrophy and healthy uninfected controls (12).

MAIN OUTCOME MEASURES

Plasma adiponectin and leptin levels were measured in the fasting state. Body composition was assessed by physical examination, dual-energy x-ray absorptiometry and computed tomography. Insulin sensitivity (S(I)) was measured using the insulin-modified frequently sampled intravenous glucose tolerance test.

RESULTS

Leptin levels were significantly higher in HIV-infected men with lipodystrophy as compared to HIV-infected controls (5.2 vs 3.0 ng/ml, P=0.01). Across the entire study population, leptin levels were positively correlated with measures of general adiposity. In the HIV-infected patients, leptin levels were negatively correlated with S(I) after adjustment for fat mass (r=-0.38, P=0.07). Adiponectin levels were significantly lower in HIV-infected men with lipodystrophy as compared to both HIV-infected and healthy controls (1.6 vs 3.4 microg/ml, P<0.05 and 1.6 vs 6.7 microg/ml, P<0.001, respectively). Adiponectin levels, after adjustment for fat mass, were correlated with measures of fat distribution. Finally, in the HIV-infected patients, adiponectin levels were significantly and positively correlated with S(I) after adjustment for fat mass (r=0.75, P < or = 0.001), and adiponectin level was also an independent determinant of S(I).

CONCLUSIONS

Plasma leptin and adiponectin levels are altered in the HIV lipodystrophy syndrome. Adiponectin deficiency may play a role in the insulin resistance associated with HIV lipodystrophy.

Authors+Show Affiliations

Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Col., USA. Lisa.Kosmiski@uchsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12713059

Citation

Kosmiski, Lisa, et al. "Adipocyte-derived Hormone Levels in HIV Lipodystrophy." Antiviral Therapy, vol. 8, no. 1, 2003, pp. 9-15.
Kosmiski L, Kuritzkes D, Lichtenstein K, et al. Adipocyte-derived hormone levels in HIV lipodystrophy. Antivir Ther (Lond). 2003;8(1):9-15.
Kosmiski, L., Kuritzkes, D., Lichtenstein, K., & Eckel, R. (2003). Adipocyte-derived hormone levels in HIV lipodystrophy. Antiviral Therapy, 8(1), pp. 9-15.
Kosmiski L, et al. Adipocyte-derived Hormone Levels in HIV Lipodystrophy. Antivir Ther (Lond). 2003;8(1):9-15. PubMed PMID: 12713059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipocyte-derived hormone levels in HIV lipodystrophy. AU - Kosmiski,Lisa, AU - Kuritzkes,Daniel, AU - Lichtenstein,Kenneth, AU - Eckel,Robert, PY - 2003/4/26/pubmed PY - 2003/7/30/medline PY - 2003/4/26/entrez SP - 9 EP - 15 JF - Antiviral therapy JO - Antivir. Ther. (Lond.) VL - 8 IS - 1 N2 - OBJECTIVE: Despite evidence for the role of adipocyte-derived hormones in insulin resistance, little is known about their levels in human lipodystrophic states. We examined the relationships of plasma leptin and adiponectin levels to fat distribution and insulin sensitivity in the HIV lipodystrophy syndrome. DESIGN: Cross-sectional study SETTING: HIV primary care practices PATIENTS: HIV-infected men with (n=13) and without (12) lipodystrophy and healthy uninfected controls (12). MAIN OUTCOME MEASURES: Plasma adiponectin and leptin levels were measured in the fasting state. Body composition was assessed by physical examination, dual-energy x-ray absorptiometry and computed tomography. Insulin sensitivity (S(I)) was measured using the insulin-modified frequently sampled intravenous glucose tolerance test. RESULTS: Leptin levels were significantly higher in HIV-infected men with lipodystrophy as compared to HIV-infected controls (5.2 vs 3.0 ng/ml, P=0.01). Across the entire study population, leptin levels were positively correlated with measures of general adiposity. In the HIV-infected patients, leptin levels were negatively correlated with S(I) after adjustment for fat mass (r=-0.38, P=0.07). Adiponectin levels were significantly lower in HIV-infected men with lipodystrophy as compared to both HIV-infected and healthy controls (1.6 vs 3.4 microg/ml, P<0.05 and 1.6 vs 6.7 microg/ml, P<0.001, respectively). Adiponectin levels, after adjustment for fat mass, were correlated with measures of fat distribution. Finally, in the HIV-infected patients, adiponectin levels were significantly and positively correlated with S(I) after adjustment for fat mass (r=0.75, P < or = 0.001), and adiponectin level was also an independent determinant of S(I). CONCLUSIONS: Plasma leptin and adiponectin levels are altered in the HIV lipodystrophy syndrome. Adiponectin deficiency may play a role in the insulin resistance associated with HIV lipodystrophy. SN - 1359-6535 UR - https://www.unboundmedicine.com/medline/citation/12713059/Adipocyte_derived_hormone_levels_in_HIV_lipodystrophy_ L2 - http://www.diseaseinfosearch.org/result/4261 DB - PRIME DP - Unbound Medicine ER -