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Phenolic compounds from Nymphaea odorata.
J Nat Prod. 2003 Apr; 66(4):548-50.JN

Abstract

Assay-guided fractionation of the ethanol extract of Nymphaea odorata resulted in the identification of two lignans, one new (1) and one known (2), together with six known flavonol glycosides (3-8). The structures of 1-8 were established by spectroscopic analysis as nymphaeoside A (1), icariside E(4) (2), kaempferol 3-O-alpha-l-rhamnopyranoside (afzelin, 3), quercetin 3-O-alpha-l-rhamnopyranoside (4), myricetin 3-O-alpha-l-rhamnopyranoside (myricitrin, 5), quercetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (6), myricetin 3-O-beta-d-galactopyranoside (7), and myricetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (8). Compounds 3, 4, and 7 showed marginal inhibitory effect against fatty acid synthase with IC(50) values of 45, 50, and 25 microg/mL, respectively.

Authors+Show Affiliations

Zhang Z
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
ElSohly HN
No affiliation info available
Li XC
No affiliation info available
Khan SI
No affiliation info available
Broedel SE
No affiliation info available
Raulli RE
No affiliation info available
Cihlar RL
No affiliation info available
Burandt C
No affiliation info available
Walker LA
No affiliation info available

MeSH

Enzyme InhibitorsFatty Acid SynthasesFlavonoidsFloridaGlycosidesHydrolysisInhibitory Concentration 50LignansMolecular StructureNuclear Magnetic Resonance, BiomolecularNymphaeaPhenolsPlant LeavesPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12713413

Citation

Zhang, Zhizhen, et al. "Phenolic Compounds From Nymphaea Odorata." Journal of Natural Products, vol. 66, no. 4, 2003, pp. 548-50.
Zhang Z, ElSohly HN, Li XC, et al. Phenolic compounds from Nymphaea odorata. J Nat Prod. 2003;66(4):548-50.
Zhang, Z., ElSohly, H. N., Li, X. C., Khan, S. I., Broedel, S. E., Raulli, R. E., Cihlar, R. L., Burandt, C., & Walker, L. A. (2003). Phenolic compounds from Nymphaea odorata. Journal of Natural Products, 66(4), 548-50.
Zhang Z, et al. Phenolic Compounds From Nymphaea Odorata. J Nat Prod. 2003;66(4):548-50. PubMed PMID: 12713413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenolic compounds from Nymphaea odorata. AU - Zhang,Zhizhen, AU - ElSohly,Hala N, AU - Li,Xing-Cong, AU - Khan,Shabana I, AU - Broedel,Sheldon E,Jr AU - Raulli,Robert E, AU - Cihlar,Ronald L, AU - Burandt,Charles, AU - Walker,Larry A, PY - 2003/4/26/pubmed PY - 2003/10/3/medline PY - 2003/4/26/entrez SP - 548 EP - 50 JF - Journal of natural products JO - J Nat Prod VL - 66 IS - 4 N2 - Assay-guided fractionation of the ethanol extract of Nymphaea odorata resulted in the identification of two lignans, one new (1) and one known (2), together with six known flavonol glycosides (3-8). The structures of 1-8 were established by spectroscopic analysis as nymphaeoside A (1), icariside E(4) (2), kaempferol 3-O-alpha-l-rhamnopyranoside (afzelin, 3), quercetin 3-O-alpha-l-rhamnopyranoside (4), myricetin 3-O-alpha-l-rhamnopyranoside (myricitrin, 5), quercetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (6), myricetin 3-O-beta-d-galactopyranoside (7), and myricetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (8). Compounds 3, 4, and 7 showed marginal inhibitory effect against fatty acid synthase with IC(50) values of 45, 50, and 25 microg/mL, respectively. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/12713413/Phenolic_compounds_from_Nymphaea_odorata_ DB - PRIME DP - Unbound Medicine ER -