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Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women.
Arterioscler Thromb Vasc Biol. 2003 Jun 01; 23(6):1066-71.AT

Abstract

OBJECTIVE

This study was undertaken to address the vascular effects of isolated isoflavones as potential contributors to their cardioprotective properties, focusing on biochanin and formononetin.

METHODS AND RESULTS

In a randomized, double-blind trial, 80 healthy subjects, 46 men and 34 women, 45 to 75 years of age, received isoflavones enriched in either biochanin or formononetin (precursors of genistein and daidzein; 80 mg/d) crossed over randomly with placebo in two 6-week periods. The end points were measured at baseline and after each intervention and included large artery stiffness (systemic arterial compliance and pulse wave velocity), endothelial function in conduit arteries (flow-mediated vasodilation), 24-hour ambulatory blood pressure, and total peripheral resistance. Isoflavone intervention significantly reduced arterial stiffness with improved systemic arterial compliance (P=0.04; repeated-measures ANOVA, Bonferroni correction) attributable to a reduction in total peripheral resistance (P=0.03) and a corresponding reduction in central pulse wave velocity (P=0.02) compared with placebo. Isoflavones did not affect blood pressure (P=0.5) or flow-mediated vasodilation (P=0.44). Improvements seemed limited to formononetin-enriched isoflavones (adjusted P=0.06). Formononetin treatment also reduced circulating vascular adhesion cell molecule-1 (P<0.01).

CONCLUSIONS

In normotensive men and postmenopausal women, red clover isoflavones enriched in formononetin reduced arterial stiffness and total vascular resistance but had no effect on blood pressure. These effects may partly explain the lower cardiovascular risk in populations eating isoflavone-rich diets.

Authors+Show Affiliations

Vascular Research Group, Department of Medicine, Monash University, Clayton, Australia. h.teede@southernhealth.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12714433

Citation

Teede, Helena J., et al. "Isoflavones Reduce Arterial Stiffness: a Placebo-controlled Study in Men and Postmenopausal Women." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 6, 2003, pp. 1066-71.
Teede HJ, McGrath BP, DeSilva L, et al. Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arterioscler Thromb Vasc Biol. 2003;23(6):1066-71.
Teede, H. J., McGrath, B. P., DeSilva, L., Cehun, M., Fassoulakis, A., & Nestel, P. J. (2003). Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(6), 1066-71.
Teede HJ, et al. Isoflavones Reduce Arterial Stiffness: a Placebo-controlled Study in Men and Postmenopausal Women. Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):1066-71. PubMed PMID: 12714433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. AU - Teede,Helena J, AU - McGrath,Barry P, AU - DeSilva,Lakmini, AU - Cehun,Marja, AU - Fassoulakis,Andriana, AU - Nestel,Paul J, Y1 - 2003/04/24/ PY - 2003/4/26/pubmed PY - 2004/2/27/medline PY - 2003/4/26/entrez SP - 1066 EP - 71 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 23 IS - 6 N2 - OBJECTIVE: This study was undertaken to address the vascular effects of isolated isoflavones as potential contributors to their cardioprotective properties, focusing on biochanin and formononetin. METHODS AND RESULTS: In a randomized, double-blind trial, 80 healthy subjects, 46 men and 34 women, 45 to 75 years of age, received isoflavones enriched in either biochanin or formononetin (precursors of genistein and daidzein; 80 mg/d) crossed over randomly with placebo in two 6-week periods. The end points were measured at baseline and after each intervention and included large artery stiffness (systemic arterial compliance and pulse wave velocity), endothelial function in conduit arteries (flow-mediated vasodilation), 24-hour ambulatory blood pressure, and total peripheral resistance. Isoflavone intervention significantly reduced arterial stiffness with improved systemic arterial compliance (P=0.04; repeated-measures ANOVA, Bonferroni correction) attributable to a reduction in total peripheral resistance (P=0.03) and a corresponding reduction in central pulse wave velocity (P=0.02) compared with placebo. Isoflavones did not affect blood pressure (P=0.5) or flow-mediated vasodilation (P=0.44). Improvements seemed limited to formononetin-enriched isoflavones (adjusted P=0.06). Formononetin treatment also reduced circulating vascular adhesion cell molecule-1 (P<0.01). CONCLUSIONS: In normotensive men and postmenopausal women, red clover isoflavones enriched in formononetin reduced arterial stiffness and total vascular resistance but had no effect on blood pressure. These effects may partly explain the lower cardiovascular risk in populations eating isoflavone-rich diets. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/12714433/Isoflavones_reduce_arterial_stiffness:_a_placebo_controlled_study_in_men_and_postmenopausal_women_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000072967.97296.4A?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -