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Protective effects of isoflavone on some biochemical parameters affected by cypermethrin in male rabbits.
J Environ Sci Health B. 2003 May; 38(3):365-78.JE

Abstract

Effect of isoflavone on cypermethrin-induced changes in enzyme activities and free radicals was studied in plasma, liver, brain and testes of male New Zealand White rabbits. Rabbits were orally given sublethal dose of cypermethrin (24 mg/kg BW; 1/100 LD50), while isoflavone (2 mg/kg BW) was given alone or in combination with cypermethrin. The tested doses were given to rabbits every other day for 12 weeks. Results obtained showed that cypermethrin significantly (P < 0.05) induced free radicals in plasma, liver, brain and testes. The activities of glutathione S-transferase (GST) (liver, brain and testes), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (liver and testes), and alkaline phosphatase (AlP) (liver) were significantly (P < 0.05) decreased due to cypermethrin administration. Contrariwise, the activities of GST, AST, ALT and AIP were increased in plasma. The activity of acetylcholinesterase (AChE) did not change in plasma and brain of treated rabbits with cypermethrin. Isoflavone alone significantly (p < 0.05) decreased the levels of free radicals in plasma, liver, brain and testes, while did not produce any significant effect on the investigated enzymes. However, isoflavone is able to reverse the changes in enzyme activities due to the effect of cypermethrin. Results concluded that isoflavone confers marked protection against cypermethrin-induced oxidative stress in rabbit's plasma, liver, brain and testes.

Authors+Show Affiliations

Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt. feldemerdash@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12716053

Citation

el-Demerdash, F M., et al. "Protective Effects of Isoflavone On some Biochemical Parameters Affected By Cypermethrin in Male Rabbits." Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes, vol. 38, no. 3, 2003, pp. 365-78.
el-Demerdash FM, Yousef MI, Al-Salhen KS. Protective effects of isoflavone on some biochemical parameters affected by cypermethrin in male rabbits. J Environ Sci Health B. 2003;38(3):365-78.
el-Demerdash, F. M., Yousef, M. I., & Al-Salhen, K. S. (2003). Protective effects of isoflavone on some biochemical parameters affected by cypermethrin in male rabbits. Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes, 38(3), 365-78.
el-Demerdash FM, Yousef MI, Al-Salhen KS. Protective Effects of Isoflavone On some Biochemical Parameters Affected By Cypermethrin in Male Rabbits. J Environ Sci Health B. 2003;38(3):365-78. PubMed PMID: 12716053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of isoflavone on some biochemical parameters affected by cypermethrin in male rabbits. AU - el-Demerdash,F M, AU - Yousef,M I, AU - Al-Salhen,K S, PY - 2003/4/29/pubmed PY - 2003/6/20/medline PY - 2003/4/29/entrez SP - 365 EP - 78 JF - Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes JO - J Environ Sci Health B VL - 38 IS - 3 N2 - Effect of isoflavone on cypermethrin-induced changes in enzyme activities and free radicals was studied in plasma, liver, brain and testes of male New Zealand White rabbits. Rabbits were orally given sublethal dose of cypermethrin (24 mg/kg BW; 1/100 LD50), while isoflavone (2 mg/kg BW) was given alone or in combination with cypermethrin. The tested doses were given to rabbits every other day for 12 weeks. Results obtained showed that cypermethrin significantly (P < 0.05) induced free radicals in plasma, liver, brain and testes. The activities of glutathione S-transferase (GST) (liver, brain and testes), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (liver and testes), and alkaline phosphatase (AlP) (liver) were significantly (P < 0.05) decreased due to cypermethrin administration. Contrariwise, the activities of GST, AST, ALT and AIP were increased in plasma. The activity of acetylcholinesterase (AChE) did not change in plasma and brain of treated rabbits with cypermethrin. Isoflavone alone significantly (p < 0.05) decreased the levels of free radicals in plasma, liver, brain and testes, while did not produce any significant effect on the investigated enzymes. However, isoflavone is able to reverse the changes in enzyme activities due to the effect of cypermethrin. Results concluded that isoflavone confers marked protection against cypermethrin-induced oxidative stress in rabbit's plasma, liver, brain and testes. SN - 0360-1234 UR - https://www.unboundmedicine.com/medline/citation/12716053/Protective_effects_of_isoflavone_on_some_biochemical_parameters_affected_by_cypermethrin_in_male_rabbits_ L2 - http://www.tandfonline.com/doi/full/10.1081/PFC-120019902 DB - PRIME DP - Unbound Medicine ER -