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Immunogenicity of purified chick embryo cell anti-rabies vaccine in post-exposure treatment of animal bite cases.
J Commun Dis. 2002 Mar; 34(1):40-2.JC

Abstract

The observations on immunogenicity of Purified Chick Embryo Cell (PCEC) anti rabies vaccination in post-exposure prophylaxis is reported. In total 207 serum samples collected from patients receiving 3 to 6 doses of PCEC were analysed for the presence of anti-rabies antibodies. The samples were collected from 10 days to 11 months after the last dose of vaccine. All the vaccinees (n=33) tested after 3 doses of PCEC showed protective titres (> or = 0.5 IU/ml) and those receiving 5-6 doses (n=161) showed 4-5 times higher than protective titres. The analysis pertains to specimens collected at one point of time only after the vaccination. However, in all 17 vaccinees where samples were collected 7-11 months after 3-6 doses of vaccine, the protective titres were sustained, these being 3-4 times higher than the protective titres in those receiving 5-6 vaccine doses. The results indicated that there was no need of routine anti-rabies antibody monitoring in healthy individuals receiving post-exposure prophylaxis in recommended doses of vaccine.

Authors+Show Affiliations

National Institute of Communicable Diseases, 22-Shamnath Marg, Delhi-110 054.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12718340

Citation

Bhardwaj, Mohan, et al. "Immunogenicity of Purified Chick Embryo Cell Anti-rabies Vaccine in Post-exposure Treatment of Animal Bite Cases." The Journal of Communicable Diseases, vol. 34, no. 1, 2002, pp. 40-2.
Bhardwaj M, Bhattacharya D, Chhabra M, et al. Immunogenicity of purified chick embryo cell anti-rabies vaccine in post-exposure treatment of animal bite cases. J Commun Dis. 2002;34(1):40-2.
Bhardwaj, M., Bhattacharya, D., Chhabra, M., & Ichhpujani, R. L. (2002). Immunogenicity of purified chick embryo cell anti-rabies vaccine in post-exposure treatment of animal bite cases. The Journal of Communicable Diseases, 34(1), 40-2.
Bhardwaj M, et al. Immunogenicity of Purified Chick Embryo Cell Anti-rabies Vaccine in Post-exposure Treatment of Animal Bite Cases. J Commun Dis. 2002;34(1):40-2. PubMed PMID: 12718340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity of purified chick embryo cell anti-rabies vaccine in post-exposure treatment of animal bite cases. AU - Bhardwaj,Mohan, AU - Bhattacharya,Dipesh, AU - Chhabra,Mala, AU - Ichhpujani,R L, PY - 2003/4/30/pubmed PY - 2003/6/12/medline PY - 2003/4/30/entrez SP - 40 EP - 2 JF - The Journal of communicable diseases JO - J Commun Dis VL - 34 IS - 1 N2 - The observations on immunogenicity of Purified Chick Embryo Cell (PCEC) anti rabies vaccination in post-exposure prophylaxis is reported. In total 207 serum samples collected from patients receiving 3 to 6 doses of PCEC were analysed for the presence of anti-rabies antibodies. The samples were collected from 10 days to 11 months after the last dose of vaccine. All the vaccinees (n=33) tested after 3 doses of PCEC showed protective titres (> or = 0.5 IU/ml) and those receiving 5-6 doses (n=161) showed 4-5 times higher than protective titres. The analysis pertains to specimens collected at one point of time only after the vaccination. However, in all 17 vaccinees where samples were collected 7-11 months after 3-6 doses of vaccine, the protective titres were sustained, these being 3-4 times higher than the protective titres in those receiving 5-6 vaccine doses. The results indicated that there was no need of routine anti-rabies antibody monitoring in healthy individuals receiving post-exposure prophylaxis in recommended doses of vaccine. SN - 0019-5138 UR - https://www.unboundmedicine.com/medline/citation/12718340/Immunogenicity_of_purified_chick_embryo_cell_anti_rabies_vaccine_in_post_exposure_treatment_of_animal_bite_cases_ L2 - http://www.diseaseinfosearch.org/result/6131 DB - PRIME DP - Unbound Medicine ER -