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Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men.
Br J Nutr. 2003 May; 89(5):695-703.BJ

Abstract

As a result of evidence documenting harmful effects of Zn supplementation on immune function and Cu status, thirty-eight men were recruited onto a Zn supplementation trial. The aim was to examine the effects of chronic Zn supplementation on circulating levels of peripheral blood leucocytes and lymphocyte subsets. Subjects (n 19) took 30 mg Zn/d for 14 weeks followed by 3 mg Cu/d for 8 weeks to counteract adverse effects, if any, of Zn supplementation on immune status resulting from lowered Cu status. A control group (n 19) took placebo supplements for the duration of the trial. Dietary intakes of Zn approximated 10 mg/d. Blood samples, taken throughout the trial, were assessed for full blood profiles and flow cytometric analyses of lymphocyte subsets. Putative indices of Cu status were also examined. Results indicate that there was no effect of Zn supplementation on circulating levels of peripheral blood leucocytes or on lymphocyte subsets. Cu status was also unaltered. Independent of supplement, there appeared to be seasonal variations in selected lymphocyte subsets in both placebo and supplemented groups. Alterations in circulating levels of B cells (cluster of differentiation (CD) 19), memory T cells (CD45RO) and expression of the intracellular adhesion molecule-1 (CD54) on T cells were observed. Findings indicated no adverse effects of Zn supplementation on immune status or Cu status and support the US upper level of Zn tolerance of 40 mg/d. The seasonal variations observed in lymphocyte subsets in the group as a whole could have implications for seasonal variability in the incidence of infectious diseases.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Ulster, Northern Ireland Centre for Food and Health (NICHE), Coleraine BT52 1SA, Northern Ireland, UK. mp.bonham@ulst.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12720590

Citation

Bonham, Maxine, et al. "Zinc Supplementation Has No Effect On Circulating Levels of Peripheral Blood Leucocytes and Lymphocyte Subsets in Healthy Adult Men." The British Journal of Nutrition, vol. 89, no. 5, 2003, pp. 695-703.
Bonham M, O'Connor JM, Alexander HD, et al. Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men. Br J Nutr. 2003;89(5):695-703.
Bonham, M., O'Connor, J. M., Alexander, H. D., Coulter, J., Walsh, P. M., McAnena, L. B., Downes, C. S., Hannigan, B. M., & Strain, J. J. (2003). Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men. The British Journal of Nutrition, 89(5), 695-703.
Bonham M, et al. Zinc Supplementation Has No Effect On Circulating Levels of Peripheral Blood Leucocytes and Lymphocyte Subsets in Healthy Adult Men. Br J Nutr. 2003;89(5):695-703. PubMed PMID: 12720590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men. AU - Bonham,Maxine, AU - O'Connor,Jacqueline M, AU - Alexander,H Denis, AU - Coulter,James, AU - Walsh,Paula M, AU - McAnena,Liadhan B, AU - Downes,C Stephen, AU - Hannigan,Bernadette M, AU - Strain,J J, PY - 2003/5/2/pubmed PY - 2003/6/10/medline PY - 2003/5/2/entrez SP - 695 EP - 703 JF - The British journal of nutrition JO - Br J Nutr VL - 89 IS - 5 N2 - As a result of evidence documenting harmful effects of Zn supplementation on immune function and Cu status, thirty-eight men were recruited onto a Zn supplementation trial. The aim was to examine the effects of chronic Zn supplementation on circulating levels of peripheral blood leucocytes and lymphocyte subsets. Subjects (n 19) took 30 mg Zn/d for 14 weeks followed by 3 mg Cu/d for 8 weeks to counteract adverse effects, if any, of Zn supplementation on immune status resulting from lowered Cu status. A control group (n 19) took placebo supplements for the duration of the trial. Dietary intakes of Zn approximated 10 mg/d. Blood samples, taken throughout the trial, were assessed for full blood profiles and flow cytometric analyses of lymphocyte subsets. Putative indices of Cu status were also examined. Results indicate that there was no effect of Zn supplementation on circulating levels of peripheral blood leucocytes or on lymphocyte subsets. Cu status was also unaltered. Independent of supplement, there appeared to be seasonal variations in selected lymphocyte subsets in both placebo and supplemented groups. Alterations in circulating levels of B cells (cluster of differentiation (CD) 19), memory T cells (CD45RO) and expression of the intracellular adhesion molecule-1 (CD54) on T cells were observed. Findings indicated no adverse effects of Zn supplementation on immune status or Cu status and support the US upper level of Zn tolerance of 40 mg/d. The seasonal variations observed in lymphocyte subsets in the group as a whole could have implications for seasonal variability in the incidence of infectious diseases. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/12720590/Zinc_supplementation_has_no_effect_on_circulating_levels_of_peripheral_blood_leucocytes_and_lymphocyte_subsets_in_healthy_adult_men_ L2 - https://www.cambridge.org/core/product/identifier/S0007114503000837/type/journal_article DB - PRIME DP - Unbound Medicine ER -