Tags

Type your tag names separated by a space and hit enter

T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy.
J Infect Dis. 2003 May 15; 187(10):1534-43.JI

Abstract

Although T cell activation is associated with disease progression in untreated human immunodeficiency virus type 1 (HIV-1) infection, its significance in antiretroviral-treated patients is unknown. Activated (CD38(+)HLA-DR(+)) T cell counts were measured in 99 HIV-infected adults who had maintained a plasma HIV RNA level <or=1000 copies/mL for a median of 21 months while receiving antiretroviral therapy. Patients with sustained viral suppression had lower levels of T cell activation than untreated patients but higher levels than HIV-uninfected control subjects. Persistent T cell activation was associated with decreased CD4(+) T cell gains during therapy. For every 5% increase in the proportion of activated CD8(+) T cells, 35 fewer CD4(+) T cells/mm(3) were gained. Increased T cell activation was associated with shorter duration of viral suppression, hepatitis C virus coinfection, frequent low-level viremia, and lower nadir CD4(+) T cell counts. Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy.

Authors+Show Affiliations

Positive Health Program, San Francisco General Hospital, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA. huntpw@medicine.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12721933

Citation

Hunt, Peter W., et al. "T Cell Activation Is Associated With Lower CD4+ T Cell Gains in Human Immunodeficiency Virus-infected Patients With Sustained Viral Suppression During Antiretroviral Therapy." The Journal of Infectious Diseases, vol. 187, no. 10, 2003, pp. 1534-43.
Hunt PW, Martin JN, Sinclair E, et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003;187(10):1534-43.
Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B., Hagos, E., Lampiris, H., & Deeks, S. G. (2003). T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. The Journal of Infectious Diseases, 187(10), 1534-43.
Hunt PW, et al. T Cell Activation Is Associated With Lower CD4+ T Cell Gains in Human Immunodeficiency Virus-infected Patients With Sustained Viral Suppression During Antiretroviral Therapy. J Infect Dis. 2003 May 15;187(10):1534-43. PubMed PMID: 12721933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. AU - Hunt,Peter W, AU - Martin,Jeffrey N, AU - Sinclair,Elizabeth, AU - Bredt,Barry, AU - Hagos,Elilta, AU - Lampiris,Harry, AU - Deeks,Steven G, Y1 - 2003/04/23/ PY - 2002/10/17/received PY - 2002/12/13/accepted PY - 2003/5/2/pubmed PY - 2003/6/28/medline PY - 2003/5/2/entrez SP - 1534 EP - 43 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 187 IS - 10 N2 - Although T cell activation is associated with disease progression in untreated human immunodeficiency virus type 1 (HIV-1) infection, its significance in antiretroviral-treated patients is unknown. Activated (CD38(+)HLA-DR(+)) T cell counts were measured in 99 HIV-infected adults who had maintained a plasma HIV RNA level <or=1000 copies/mL for a median of 21 months while receiving antiretroviral therapy. Patients with sustained viral suppression had lower levels of T cell activation than untreated patients but higher levels than HIV-uninfected control subjects. Persistent T cell activation was associated with decreased CD4(+) T cell gains during therapy. For every 5% increase in the proportion of activated CD8(+) T cells, 35 fewer CD4(+) T cells/mm(3) were gained. Increased T cell activation was associated with shorter duration of viral suppression, hepatitis C virus coinfection, frequent low-level viremia, and lower nadir CD4(+) T cell counts. Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12721933/T_cell_activation_is_associated_with_lower_CD4+_T_cell_gains_in_human_immunodeficiency_virus_infected_patients_with_sustained_viral_suppression_during_antiretroviral_therapy_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/374786 DB - PRIME DP - Unbound Medicine ER -