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Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia.
J Infect Dis. 2003 May 15; 187(10):1581-6.JI

Abstract

Parvovirus B19 has been proposed as the etiological agent of fulminant hepatitis (FH) or hepatitis-associated aplastic anemia (HAA). We studied the prevalence of parvovirus B19 in liver-tissue samples from patients with FH and HAA and from control subjects. In the first study, parvovirus B19 DNA was detected by nested polymerase chain reaction (PCR) in 4 of 15 livers from patients with FH and in 3 of 22 livers from patients with nonviral hepatic disease. In a second confirmatory study, livers were tested for parvovirus B19 and its variant erythroviruses, V9 and A6. Tissues were also tested by reverse-transcriptase PCR for the presence of parvovirus B19 transcripts as a marker of viral replication. There was no significant difference in the prevalence of parvovirus B19 DNA in livers from patients with FH or HAA, compared with liver-tissue samples from patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection; parvovirus B19 transcripts were not detected. There was a significant increase (P<.1) in the prevalence of variant erythrovirus sequences in livers of patients with HBV or HCV hepatitis, the reason for which is currently unknown.

Authors+Show Affiliations

Virus Discovery Group, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12721938

Citation

Wong, Susan, et al. "Prevalence of Parvovirus B19 in Liver Tissue: No Association With Fulminant Hepatitis or Hepatitis-associated Aplastic Anemia." The Journal of Infectious Diseases, vol. 187, no. 10, 2003, pp. 1581-6.
Wong S, Young NS, Brown KE. Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia. J Infect Dis. 2003;187(10):1581-6.
Wong, S., Young, N. S., & Brown, K. E. (2003). Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia. The Journal of Infectious Diseases, 187(10), 1581-6.
Wong S, Young NS, Brown KE. Prevalence of Parvovirus B19 in Liver Tissue: No Association With Fulminant Hepatitis or Hepatitis-associated Aplastic Anemia. J Infect Dis. 2003 May 15;187(10):1581-6. PubMed PMID: 12721938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia. AU - Wong,Susan, AU - Young,Neal S, AU - Brown,Kevin E, Y1 - 2003/04/23/ PY - 2002/09/16/received PY - 2002/12/19/accepted PY - 2003/5/2/pubmed PY - 2003/6/28/medline PY - 2003/5/2/entrez SP - 1581 EP - 6 JF - The Journal of infectious diseases JO - J Infect Dis VL - 187 IS - 10 N2 - Parvovirus B19 has been proposed as the etiological agent of fulminant hepatitis (FH) or hepatitis-associated aplastic anemia (HAA). We studied the prevalence of parvovirus B19 in liver-tissue samples from patients with FH and HAA and from control subjects. In the first study, parvovirus B19 DNA was detected by nested polymerase chain reaction (PCR) in 4 of 15 livers from patients with FH and in 3 of 22 livers from patients with nonviral hepatic disease. In a second confirmatory study, livers were tested for parvovirus B19 and its variant erythroviruses, V9 and A6. Tissues were also tested by reverse-transcriptase PCR for the presence of parvovirus B19 transcripts as a marker of viral replication. There was no significant difference in the prevalence of parvovirus B19 DNA in livers from patients with FH or HAA, compared with liver-tissue samples from patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection; parvovirus B19 transcripts were not detected. There was a significant increase (P<.1) in the prevalence of variant erythrovirus sequences in livers of patients with HBV or HCV hepatitis, the reason for which is currently unknown. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12721938/Prevalence_of_parvovirus_B19_in_liver_tissue:_no_association_with_fulminant_hepatitis_or_hepatitis_associated_aplastic_anemia_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/374781 DB - PRIME DP - Unbound Medicine ER -