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Association of depression with malnutrition in chronic hemodialysis patients.
Am J Kidney Dis 2003; 41(5):1037-42AJ

Abstract

BACKGROUND

Depression is the most common psychological complication and may increase mortality in chronic hemodialysis patients. Because depression could be associated with poor oral intake and activation of proinflammatory cytokines that could further increase mortality by malnutrition, we investigated the relation between depression and nutritional status in chronic hemodialysis patients.

METHODS

Sixty-two Korean patients completed the Beck Depression Inventory (BDI) questionnaire, and the diagnosis of depression was confirmed by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for major depressive disorder. Nutritional status was evaluated using serum albumin level, normalized protein catabolic rate, subjective global assessment (SGA), and anthropometric measurement.

RESULTS

Mean BDI score was 22.7 +/- 11.4, and 35 patients (56.5%) had a BDI score greater than 21, which is the suggested cutoff score for the diagnosis of depression for the Korean population. Of 40 patients who had a score higher than 18 on the BDI, 34 patients met DSM-IV criteria for major depressive disorder. BDI score correlated negatively with a variety of nutritional parameters: serum albumin level (r = -0.47; P < 0.001), normalized protein catabolic rate (r = -0.32; P < 0.05), SGA (r = -0.47; P < 0.01), triceps skinfold thickness (r = -0.40; P < 0.05), midarm muscle circumference (r = -0.57; P < 0.01), and body mass index (r = -0.28; P < 0.05). Multiple regression analysis also identified BDI score as an independent determinant for all kinds of nutritional parameters.

CONCLUSION

In patients on chronic hemodialysis therapy, depression is related closely to nutritional status and could be an independent risk factor for malnutrition.

Authors+Show Affiliations

Department of Internal Medicine, Division of Nephrology, College of Medicine, Hallym University, Chuchon, Kangwon Do, South Korea. jrkoo@hallym.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12722038

Citation

Koo, Ja-Ryong, et al. "Association of Depression With Malnutrition in Chronic Hemodialysis Patients." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 41, no. 5, 2003, pp. 1037-42.
Koo JR, Yoon JW, Kim SG, et al. Association of depression with malnutrition in chronic hemodialysis patients. Am J Kidney Dis. 2003;41(5):1037-42.
Koo, J. R., Yoon, J. W., Kim, S. G., Lee, Y. K., Oh, K. H., Kim, G. H., ... Son, B. K. (2003). Association of depression with malnutrition in chronic hemodialysis patients. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 41(5), pp. 1037-42.
Koo JR, et al. Association of Depression With Malnutrition in Chronic Hemodialysis Patients. Am J Kidney Dis. 2003;41(5):1037-42. PubMed PMID: 12722038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of depression with malnutrition in chronic hemodialysis patients. AU - Koo,Ja-Ryong, AU - Yoon,Jong-Woo, AU - Kim,Seong-Gyun, AU - Lee,Young-Ki, AU - Oh,Kook-Hwan, AU - Kim,Gheun-Ho, AU - Kim,Hyung-Jik, AU - Chae,Dong-Wan, AU - Noh,Jung-Woo, AU - Lee,Sang-Kyu, AU - Son,Bong-Ki, PY - 2003/5/2/pubmed PY - 2004/1/9/medline PY - 2003/5/2/entrez SP - 1037 EP - 42 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 41 IS - 5 N2 - BACKGROUND: Depression is the most common psychological complication and may increase mortality in chronic hemodialysis patients. Because depression could be associated with poor oral intake and activation of proinflammatory cytokines that could further increase mortality by malnutrition, we investigated the relation between depression and nutritional status in chronic hemodialysis patients. METHODS: Sixty-two Korean patients completed the Beck Depression Inventory (BDI) questionnaire, and the diagnosis of depression was confirmed by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for major depressive disorder. Nutritional status was evaluated using serum albumin level, normalized protein catabolic rate, subjective global assessment (SGA), and anthropometric measurement. RESULTS: Mean BDI score was 22.7 +/- 11.4, and 35 patients (56.5%) had a BDI score greater than 21, which is the suggested cutoff score for the diagnosis of depression for the Korean population. Of 40 patients who had a score higher than 18 on the BDI, 34 patients met DSM-IV criteria for major depressive disorder. BDI score correlated negatively with a variety of nutritional parameters: serum albumin level (r = -0.47; P < 0.001), normalized protein catabolic rate (r = -0.32; P < 0.05), SGA (r = -0.47; P < 0.01), triceps skinfold thickness (r = -0.40; P < 0.05), midarm muscle circumference (r = -0.57; P < 0.01), and body mass index (r = -0.28; P < 0.05). Multiple regression analysis also identified BDI score as an independent determinant for all kinds of nutritional parameters. CONCLUSION: In patients on chronic hemodialysis therapy, depression is related closely to nutritional status and could be an independent risk factor for malnutrition. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/12722038/Association_of_depression_with_malnutrition_in_chronic_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272638603002014 DB - PRIME DP - Unbound Medicine ER -