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Short-term effect of a single levodopa dose on micturition disturbance in Parkinson's disease patients with the wearing-off phenomenon.
Mov Disord. 2003 May; 18(5):573-8.MD

Abstract

We investigated the short-term effects of a single dose of levodopa (L-dopa) on micturition function in PD patients with wearing-off phenomenon. Eighteen PD patients who had median Hoehn and Yahr scores of 5 during the off phase and 3 during the on phase were recruited. We carried out urodynamic studies before and about 1 hour after the patients had taken 100 mg of L-dopa with dopa-decarboxylase inhibitor (DCI). After taking the L-dopa/DCI, urinary urgency and urge incontinence aggravated, whereas voiding difficulty was alleviated in all 12 patients. When compared to the baseline assessment, urodynamic study results after taking 100 mg of L-dopa/DCI showed aggravated detrusor hyperreflexia; decreased maximum bladder capacity (P = 0.006); an increased maximum Watts Factor value (P = 0.001), reflecting the detrusor power on voiding; an increased Abrams-Griffiths number (P = 0.042), reflecting urethral obstruction on voiding; decreased residual urine volume (P = 0.025); and increased static urethral closure pressure (P = 0.012). One hundred milligrams of L-dopa/DCI worsened detrusor hyperreflexia, producing worsened urinary urgency and urge incontinence during the storage (bladder-filling) phase. It also increased detrusor contractility much more than it did urethral obstruction in the voiding phase, producing overall lessening of voiding difficulty and improving voiding efficiency in our PD patients with the wearing-off phenomenon.

Authors+Show Affiliations

Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. uchito@js5.so-net.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12722172

Citation

Uchiyama, Tomoyuki, et al. "Short-term Effect of a Single Levodopa Dose On Micturition Disturbance in Parkinson's Disease Patients With the Wearing-off Phenomenon." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 18, no. 5, 2003, pp. 573-8.
Uchiyama T, Sakakibara R, Hattori T, et al. Short-term effect of a single levodopa dose on micturition disturbance in Parkinson's disease patients with the wearing-off phenomenon. Mov Disord. 2003;18(5):573-8.
Uchiyama, T., Sakakibara, R., Hattori, T., & Yamanishi, T. (2003). Short-term effect of a single levodopa dose on micturition disturbance in Parkinson's disease patients with the wearing-off phenomenon. Movement Disorders : Official Journal of the Movement Disorder Society, 18(5), 573-8.
Uchiyama T, et al. Short-term Effect of a Single Levodopa Dose On Micturition Disturbance in Parkinson's Disease Patients With the Wearing-off Phenomenon. Mov Disord. 2003;18(5):573-8. PubMed PMID: 12722172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effect of a single levodopa dose on micturition disturbance in Parkinson's disease patients with the wearing-off phenomenon. AU - Uchiyama,Tomoyuki, AU - Sakakibara,Ryuji, AU - Hattori,Takamichi, AU - Yamanishi,Tomonori, PY - 2003/5/2/pubmed PY - 2003/9/18/medline PY - 2003/5/2/entrez SP - 573 EP - 8 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 18 IS - 5 N2 - We investigated the short-term effects of a single dose of levodopa (L-dopa) on micturition function in PD patients with wearing-off phenomenon. Eighteen PD patients who had median Hoehn and Yahr scores of 5 during the off phase and 3 during the on phase were recruited. We carried out urodynamic studies before and about 1 hour after the patients had taken 100 mg of L-dopa with dopa-decarboxylase inhibitor (DCI). After taking the L-dopa/DCI, urinary urgency and urge incontinence aggravated, whereas voiding difficulty was alleviated in all 12 patients. When compared to the baseline assessment, urodynamic study results after taking 100 mg of L-dopa/DCI showed aggravated detrusor hyperreflexia; decreased maximum bladder capacity (P = 0.006); an increased maximum Watts Factor value (P = 0.001), reflecting the detrusor power on voiding; an increased Abrams-Griffiths number (P = 0.042), reflecting urethral obstruction on voiding; decreased residual urine volume (P = 0.025); and increased static urethral closure pressure (P = 0.012). One hundred milligrams of L-dopa/DCI worsened detrusor hyperreflexia, producing worsened urinary urgency and urge incontinence during the storage (bladder-filling) phase. It also increased detrusor contractility much more than it did urethral obstruction in the voiding phase, producing overall lessening of voiding difficulty and improving voiding efficiency in our PD patients with the wearing-off phenomenon. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/12722172/Short_term_effect_of_a_single_levodopa_dose_on_micturition_disturbance_in_Parkinson's_disease_patients_with_the_wearing_off_phenomenon_ L2 - https://doi.org/10.1002/mds.10403 DB - PRIME DP - Unbound Medicine ER -