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Pharmacological nutrition in inflammatory bowel diseases.
Nutr Hosp. 2003 Mar-Apr; 18(2):57-64.NH

Abstract

Inflammatory Bowel Diseases--ulcerative colitis and Crohn's disease--are chronic gastrointestinal inflammatory diseases of unknown etiology. Decreased oral intake, malabsorption, accelerated nutrient losses, increased requirements, and drug-nutrient interactions cause nutritional and functional deficiencies that require proper correction by nutritional therapy. The goals of the different forms of nutritional therapy are to correct nutritional disturbances and to modulate inflammatory response, thus influencing disease activity. Nutritional intervention may improve outcome in certain individuals; however, because of the costs and complications of such therapy, careful selection is warranted. Total parenteral nutrition has been used to correct and prevent nutritional disturbances and to promote bowel rest during active disease, mainly in cases of digestive fistulae with a high output. Its use should be reserved for patients who cannot tolerate enteral nutrition. Enteral nutrition is effective in inducing clinical remission of disease in adults and promoting growth in children. Recent research has focused on the use of specific nutrients as primary treatment agents. Although some reports have indicated that glutamine, short-chain fatty acids, antioxidants and immunonutrition with omega-3 fatty acids are an important therapeutic alternative in the management of inflammatory bowel diseases, the beneficial reported effects have yet to be translated into the clinical practice. The real efficacy of these nutrients still need further evaluation through prospective and randomized trials.

Authors+Show Affiliations

Department of Gastroenterology, Colorectal Surgery Unit, Hospital das Clinicas, University of São Paulo Medical School, Sao Paulo, Brasil. fgcampos@osite.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12723376

Citation

Campos, F G., et al. "Pharmacological Nutrition in Inflammatory Bowel Diseases." Nutricion Hospitalaria, vol. 18, no. 2, 2003, pp. 57-64.
Campos FG, Waitzberg DL, Teixeira MG, et al. Pharmacological nutrition in inflammatory bowel diseases. Nutr Hosp. 2003;18(2):57-64.
Campos, F. G., Waitzberg, D. L., Teixeira, M. G., Mucerino, D. R., Kiss, D. R., & Habr-Gama, A. (2003). Pharmacological nutrition in inflammatory bowel diseases. Nutricion Hospitalaria, 18(2), 57-64.
Campos FG, et al. Pharmacological Nutrition in Inflammatory Bowel Diseases. Nutr Hosp. 2003 Mar-Apr;18(2):57-64. PubMed PMID: 12723376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological nutrition in inflammatory bowel diseases. AU - Campos,F G, AU - Waitzberg,D L, AU - Teixeira,M G, AU - Mucerino,D R, AU - Kiss,D R, AU - Habr-Gama,A, PY - 2003/5/2/pubmed PY - 2003/6/26/medline PY - 2003/5/2/entrez SP - 57 EP - 64 JF - Nutricion hospitalaria JO - Nutr Hosp VL - 18 IS - 2 N2 - Inflammatory Bowel Diseases--ulcerative colitis and Crohn's disease--are chronic gastrointestinal inflammatory diseases of unknown etiology. Decreased oral intake, malabsorption, accelerated nutrient losses, increased requirements, and drug-nutrient interactions cause nutritional and functional deficiencies that require proper correction by nutritional therapy. The goals of the different forms of nutritional therapy are to correct nutritional disturbances and to modulate inflammatory response, thus influencing disease activity. Nutritional intervention may improve outcome in certain individuals; however, because of the costs and complications of such therapy, careful selection is warranted. Total parenteral nutrition has been used to correct and prevent nutritional disturbances and to promote bowel rest during active disease, mainly in cases of digestive fistulae with a high output. Its use should be reserved for patients who cannot tolerate enteral nutrition. Enteral nutrition is effective in inducing clinical remission of disease in adults and promoting growth in children. Recent research has focused on the use of specific nutrients as primary treatment agents. Although some reports have indicated that glutamine, short-chain fatty acids, antioxidants and immunonutrition with omega-3 fatty acids are an important therapeutic alternative in the management of inflammatory bowel diseases, the beneficial reported effects have yet to be translated into the clinical practice. The real efficacy of these nutrients still need further evaluation through prospective and randomized trials. SN - 0212-1611 UR - https://www.unboundmedicine.com/medline/citation/12723376/Pharmacological_nutrition_in_inflammatory_bowel_diseases_ DB - PRIME DP - Unbound Medicine ER -