Tags

Type your tag names separated by a space and hit enter

The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism.
Gynecol Endocrinol. 2003 Feb; 17(1):57-63.GE

Abstract

Finasteride has been used frequently in the treatment of prostate hyperplasia, but this drug inhibits 5alpha-reductase and for this reason could be useful for the treatment of hirsutism. The aim of this study was to evaluate the clinical and hormonal effects of finasteride on hirsute women with idiopathic hirsutism or polycystic ovary syndrome. Twenty-four women were randomly divided into two groups: those given placebo and those given finasteride 5 mg/day. The treatment period was 6 months. All patients were evaluated before the beginning of treatment (baseline) and after 3 and 6 months of treatment using clinical examination through Ferriman-Gallwey score, blood pressure, cardiac frequency and body mass index. Also, we collected blood for hormonal determination of levels of prolactin, 17alpha-hydroxyprogesterone, follicle stimulating hormone, luteinizing hormone, total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and dihydrotestosterone. Furthermore, all patients were asked about their concerns and satisfaction with the treatment. The results showed that the Ferriman-Gallwey score in the 6th month of finasteride treatment was significantly lower than at baseline and the 3rd month of this drug treatment. The dihydrotestosterone level in the finasteride group was also significantly reduced compared to that in the placebo group. The other hormones did not show any statistical difference during the study. All the patients treated with finasteride perceived a reduction in hirsutism after 6 months. In conclusion, our data suggest that finasteride may be effective for the treatment of the hirsute woman with idiopathic hirsutism or polycystic ovary syndrome.

Authors+Show Affiliations

Lakryc EM
Department of Gynecology of the Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil.
Motta EL
No affiliation info available
Soares JM
No affiliation info available
Haidar MA
No affiliation info available
de Lima GR
No affiliation info available
Baracat EC
No affiliation info available

MeSH

17-alpha-Hydroxyprogesterone5-alpha Reductase InhibitorsAdultAndrostenedioneBody Mass IndexDehydroepiandrosterone SulfateDihydrotestosteroneDouble-Blind MethodEnzyme InhibitorsFemaleFinasterideFollicle Stimulating HormoneHirsutismHumansLuteinizing HormoneOvaryPlacebosPolycystic Ovary SyndromeProlactinTestosteroneUltrasonography

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12724020

Citation

Lakryc, E M., et al. "The Benefits of Finasteride for Hirsute Women With Polycystic Ovary Syndrome or Idiopathic Hirsutism." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 17, no. 1, 2003, pp. 57-63.
Lakryc EM, Motta EL, Soares JM, et al. The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism. Gynecol Endocrinol. 2003;17(1):57-63.
Lakryc, E. M., Motta, E. L., Soares, J. M., Haidar, M. A., de Lima, G. R., & Baracat, E. C. (2003). The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 17(1), 57-63.
Lakryc EM, et al. The Benefits of Finasteride for Hirsute Women With Polycystic Ovary Syndrome or Idiopathic Hirsutism. Gynecol Endocrinol. 2003;17(1):57-63. PubMed PMID: 12724020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism. AU - Lakryc,E M, AU - Motta,E L A, AU - Soares,J M,Jr AU - Haidar,M A, AU - de Lima,G Rodrigues, AU - Baracat,E C, PY - 2003/5/2/pubmed PY - 2003/5/28/medline PY - 2003/5/2/entrez SP - 57 EP - 63 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 17 IS - 1 N2 - Finasteride has been used frequently in the treatment of prostate hyperplasia, but this drug inhibits 5alpha-reductase and for this reason could be useful for the treatment of hirsutism. The aim of this study was to evaluate the clinical and hormonal effects of finasteride on hirsute women with idiopathic hirsutism or polycystic ovary syndrome. Twenty-four women were randomly divided into two groups: those given placebo and those given finasteride 5 mg/day. The treatment period was 6 months. All patients were evaluated before the beginning of treatment (baseline) and after 3 and 6 months of treatment using clinical examination through Ferriman-Gallwey score, blood pressure, cardiac frequency and body mass index. Also, we collected blood for hormonal determination of levels of prolactin, 17alpha-hydroxyprogesterone, follicle stimulating hormone, luteinizing hormone, total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and dihydrotestosterone. Furthermore, all patients were asked about their concerns and satisfaction with the treatment. The results showed that the Ferriman-Gallwey score in the 6th month of finasteride treatment was significantly lower than at baseline and the 3rd month of this drug treatment. The dihydrotestosterone level in the finasteride group was also significantly reduced compared to that in the placebo group. The other hormones did not show any statistical difference during the study. All the patients treated with finasteride perceived a reduction in hirsutism after 6 months. In conclusion, our data suggest that finasteride may be effective for the treatment of the hirsute woman with idiopathic hirsutism or polycystic ovary syndrome. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/12724020/The_benefits_of_finasteride_for_hirsute_women_with_polycystic_ovary_syndrome_or_idiopathic_hirsutism_ DB - PRIME DP - Unbound Medicine ER -