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Square wave voltammetric determination of the angiotensin-converting enzyme inhibitors cilazapril, quinapril and ramipril in pharmaceutical formulations.
Farmaco. 2003 May; 58(5):343-50.F

Abstract

The angiotensin-converting enzyme inhibitors cilazapril, quinapril and ramipril are reduced at a hanging mercury drop electrode in the pH range 3.5-13 using Britton-Robinson buffers as supporting electrolyte and KCl as ionic medium. Square wave voltammetry has proved to be the most suitable electroanalytical technique for the quantitative voltammetric determination of these antihypertensive drugs. Optimisation of the chemical and instrumental variables was carried out. Analyses were performed in 0.02 M borate buffer at pH 9.5 and 0.5 M KCl as ionic medium, using a pulse amplitude of 50 mV and a frequency of 150 Hz. A linear relationship between peak current and concentration was found in the interval 0.5-8 microg/ml for cilazapril and up to 6 microg/ml for quinapril and ramipril, allowing the direct determination of their pharmaceutical formulations alone or mixed with hydrochlorothiazide. Good accuracy and repeatativity were obtained.

Authors+Show Affiliations

Departamento de Química Analítica, Facultad de Ciencias, Universidad del País Vasco/EHU, Apdo. 644, 48080 Bilbao, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12729827

Citation

Prieto, José Angel, et al. "Square Wave Voltammetric Determination of the Angiotensin-converting Enzyme Inhibitors Cilazapril, Quinapril and Ramipril in Pharmaceutical Formulations." Farmaco (Societa Chimica Italiana : 1989), vol. 58, no. 5, 2003, pp. 343-50.
Prieto JA, Jiménez RM, Alonso RM. Square wave voltammetric determination of the angiotensin-converting enzyme inhibitors cilazapril, quinapril and ramipril in pharmaceutical formulations. Farmaco. 2003;58(5):343-50.
Prieto, J. A., Jiménez, R. M., & Alonso, R. M. (2003). Square wave voltammetric determination of the angiotensin-converting enzyme inhibitors cilazapril, quinapril and ramipril in pharmaceutical formulations. Farmaco (Societa Chimica Italiana : 1989), 58(5), 343-50.
Prieto JA, Jiménez RM, Alonso RM. Square Wave Voltammetric Determination of the Angiotensin-converting Enzyme Inhibitors Cilazapril, Quinapril and Ramipril in Pharmaceutical Formulations. Farmaco. 2003;58(5):343-50. PubMed PMID: 12729827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Square wave voltammetric determination of the angiotensin-converting enzyme inhibitors cilazapril, quinapril and ramipril in pharmaceutical formulations. AU - Prieto,José Angel, AU - Jiménez,Rosa M, AU - Alonso,Rosa M, PY - 2003/5/6/pubmed PY - 2004/1/30/medline PY - 2003/5/6/entrez SP - 343 EP - 50 JF - Farmaco (Societa chimica italiana : 1989) JO - Farmaco VL - 58 IS - 5 N2 - The angiotensin-converting enzyme inhibitors cilazapril, quinapril and ramipril are reduced at a hanging mercury drop electrode in the pH range 3.5-13 using Britton-Robinson buffers as supporting electrolyte and KCl as ionic medium. Square wave voltammetry has proved to be the most suitable electroanalytical technique for the quantitative voltammetric determination of these antihypertensive drugs. Optimisation of the chemical and instrumental variables was carried out. Analyses were performed in 0.02 M borate buffer at pH 9.5 and 0.5 M KCl as ionic medium, using a pulse amplitude of 50 mV and a frequency of 150 Hz. A linear relationship between peak current and concentration was found in the interval 0.5-8 microg/ml for cilazapril and up to 6 microg/ml for quinapril and ramipril, allowing the direct determination of their pharmaceutical formulations alone or mixed with hydrochlorothiazide. Good accuracy and repeatativity were obtained. SN - 0014-827X UR - https://www.unboundmedicine.com/medline/citation/12729827/Square_wave_voltammetric_determination_of_the_angiotensin_converting_enzyme_inhibitors_cilazapril_quinapril_and_ramipril_in_pharmaceutical_formulations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-827X(03)00043-0 DB - PRIME DP - Unbound Medicine ER -