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Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise.
Rheumatology (Oxford) 2003; 42(9):1050-4R

Abstract

OBJECTIVE

To test the efficacy of a graded aerobic exercise programme in treating fatigue in systemic lupus erythematosus.

METHODS

Ninety-three patients with systemic lupus erythematosus without active disease in any major organ were randomized, using a minimization protocol, to 12 weeks of graded exercise therapy, relaxation therapy or no intervention.

RESULTS

Analysis by intention to treat showed that 16 of the 33 (49%) patients in the exercise group rated themselves as 'much' or 'very much' better compared with eight out of 29 (28%) in the relaxation group and five out of 32 (16%) in the control group (chi2=8.3, df=2, P=0.02). Fatigue improved significantly on one out of three measures after exercise therapy and there was a trend for fatigue to improve on all measures after exercise.

CONCLUSION

These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with fatigue and systemic lupus erythematosus.

Authors+Show Affiliations

National Sports Medicine Institute, The London NHS Trust, London, UK. colin.tench3@which.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12730519

Citation

Tench, C M., et al. "Fatigue in Systemic Lupus Erythematosus: a Randomized Controlled Trial of Exercise." Rheumatology (Oxford, England), vol. 42, no. 9, 2003, pp. 1050-4.
Tench CM, McCarthy J, McCurdie I, et al. Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Rheumatology (Oxford). 2003;42(9):1050-4.
Tench, C. M., McCarthy, J., McCurdie, I., White, P. D., & D'Cruz, D. P. (2003). Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Rheumatology (Oxford, England), 42(9), pp. 1050-4.
Tench CM, et al. Fatigue in Systemic Lupus Erythematosus: a Randomized Controlled Trial of Exercise. Rheumatology (Oxford). 2003;42(9):1050-4. PubMed PMID: 12730519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. AU - Tench,C M, AU - McCarthy,J, AU - McCurdie,I, AU - White,P D, AU - D'Cruz,D P, Y1 - 2003/04/16/ PY - 2003/5/6/pubmed PY - 2003/10/29/medline PY - 2003/5/6/entrez SP - 1050 EP - 4 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 42 IS - 9 N2 - OBJECTIVE: To test the efficacy of a graded aerobic exercise programme in treating fatigue in systemic lupus erythematosus. METHODS: Ninety-three patients with systemic lupus erythematosus without active disease in any major organ were randomized, using a minimization protocol, to 12 weeks of graded exercise therapy, relaxation therapy or no intervention. RESULTS: Analysis by intention to treat showed that 16 of the 33 (49%) patients in the exercise group rated themselves as 'much' or 'very much' better compared with eight out of 29 (28%) in the relaxation group and five out of 32 (16%) in the control group (chi2=8.3, df=2, P=0.02). Fatigue improved significantly on one out of three measures after exercise therapy and there was a trend for fatigue to improve on all measures after exercise. CONCLUSION: These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with fatigue and systemic lupus erythematosus. SN - 1462-0324 UR - https://www.unboundmedicine.com/medline/citation/12730519/full_citation L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/keg289 DB - PRIME DP - Unbound Medicine ER -