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Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise.

Abstract

OBJECTIVE

To test the efficacy of a graded aerobic exercise programme in treating fatigue in systemic lupus erythematosus.

METHODS

Ninety-three patients with systemic lupus erythematosus without active disease in any major organ were randomized, using a minimization protocol, to 12 weeks of graded exercise therapy, relaxation therapy or no intervention.

RESULTS

Analysis by intention to treat showed that 16 of the 33 (49%) patients in the exercise group rated themselves as 'much' or 'very much' better compared with eight out of 29 (28%) in the relaxation group and five out of 32 (16%) in the control group (chi2=8.3, df=2, P=0.02). Fatigue improved significantly on one out of three measures after exercise therapy and there was a trend for fatigue to improve on all measures after exercise.

CONCLUSION

These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with fatigue and systemic lupus erythematosus.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    National Sports Medicine Institute, The London NHS Trust, London, UK. colin.tench3@which.net

    , , ,

    Source

    Rheumatology (Oxford, England) 42:9 2003 Sep pg 1050-4

    MeSH

    Adolescent
    Adult
    Exercise Therapy
    Fatigue
    Female
    Follow-Up Studies
    Humans
    Lupus Erythematosus, Systemic
    Middle Aged
    Patient Compliance
    Patient Dropouts
    Patient Satisfaction
    Relaxation Therapy
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12730519

    Citation

    Tench, C M., et al. "Fatigue in Systemic Lupus Erythematosus: a Randomized Controlled Trial of Exercise." Rheumatology (Oxford, England), vol. 42, no. 9, 2003, pp. 1050-4.
    Tench CM, McCarthy J, McCurdie I, et al. Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Rheumatology (Oxford). 2003;42(9):1050-4.
    Tench, C. M., McCarthy, J., McCurdie, I., White, P. D., & D'Cruz, D. P. (2003). Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Rheumatology (Oxford, England), 42(9), pp. 1050-4.
    Tench CM, et al. Fatigue in Systemic Lupus Erythematosus: a Randomized Controlled Trial of Exercise. Rheumatology (Oxford). 2003;42(9):1050-4. PubMed PMID: 12730519.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. AU - Tench,C M, AU - McCarthy,J, AU - McCurdie,I, AU - White,P D, AU - D'Cruz,D P, Y1 - 2003/04/16/ PY - 2003/5/6/pubmed PY - 2003/10/29/medline PY - 2003/5/6/entrez SP - 1050 EP - 4 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 42 IS - 9 N2 - OBJECTIVE: To test the efficacy of a graded aerobic exercise programme in treating fatigue in systemic lupus erythematosus. METHODS: Ninety-three patients with systemic lupus erythematosus without active disease in any major organ were randomized, using a minimization protocol, to 12 weeks of graded exercise therapy, relaxation therapy or no intervention. RESULTS: Analysis by intention to treat showed that 16 of the 33 (49%) patients in the exercise group rated themselves as 'much' or 'very much' better compared with eight out of 29 (28%) in the relaxation group and five out of 32 (16%) in the control group (chi2=8.3, df=2, P=0.02). Fatigue improved significantly on one out of three measures after exercise therapy and there was a trend for fatigue to improve on all measures after exercise. CONCLUSION: These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with fatigue and systemic lupus erythematosus. SN - 1462-0324 UR - https://www.unboundmedicine.com/medline/citation/12730519/full_citation L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/keg289 DB - PRIME DP - Unbound Medicine ER -