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Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study.
Ann Neurol. 2003 May; 53(5):607-15.AN

Abstract

We determined whether higher endogenous estradiol levels were associated with lower risk of dementia in older men and women not using hormonal replacement therapy, using a case-cohort design within the Rotterdam Study, a population-based follow-up study on chronic diseases, including dementia, in 7983 subjects aged 55 years or older, and ongoing since 1990. The analyses were based on a random subcohort of 508 women and 438 men, and on 76 women and 53 men with incident dementia. Cox proportional hazards models with robustly estimated standard errors showed that in women higher levels of total estradiol were associated with higher risk of dementia (age-adjusted hazard ratio per standard deviation increase 1.38; 95% CI 1.04-1.84). Age-adjusted HR's of Alzheimer's disease and vascular dementia associated with higher levels of total estradiol (per SD increase) were 1.24 (95% CI 0.87-1.76) and 2.19 (95% CI 1.22-3.92), respectively. Similar results were observed for bioavailable estradiol. Additional adjustments for potential confounders did not change the results substantially. In men, no clear association was observed between estradiol levels and risk of dementia or its subtypes. The findings do not support the hypothesis that higher levels of endogenous estradiol reduce risk of dementia, neither in women nor in men.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands. m.geerlings@jc.azu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12730994

Citation

Geerlings, Mirjam I., et al. "Endogenous Estradiol and Risk of Dementia in Women and Men: the Rotterdam Study." Annals of Neurology, vol. 53, no. 5, 2003, pp. 607-15.
Geerlings MI, Launer LJ, de Jong FH, et al. Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study. Ann Neurol. 2003;53(5):607-15.
Geerlings, M. I., Launer, L. J., de Jong, F. H., Ruitenberg, A., Stijnen, T., van Swieten, J. C., Hofman, A., Witteman, J. C., Pols, H. A., & Breteler, M. M. (2003). Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study. Annals of Neurology, 53(5), 607-15.
Geerlings MI, et al. Endogenous Estradiol and Risk of Dementia in Women and Men: the Rotterdam Study. Ann Neurol. 2003;53(5):607-15. PubMed PMID: 12730994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study. AU - Geerlings,Mirjam I, AU - Launer,Lenore J, AU - de Jong,Frank H, AU - Ruitenberg,Annemieke, AU - Stijnen,Theo, AU - van Swieten,John C, AU - Hofman,Albert, AU - Witteman,Jacqueline C M, AU - Pols,Huibert A P, AU - Breteler,Monique M B, AU - ,, PY - 2003/5/6/pubmed PY - 2003/6/5/medline PY - 2003/5/6/entrez SP - 607 EP - 15 JF - Annals of neurology JO - Ann. Neurol. VL - 53 IS - 5 N2 - We determined whether higher endogenous estradiol levels were associated with lower risk of dementia in older men and women not using hormonal replacement therapy, using a case-cohort design within the Rotterdam Study, a population-based follow-up study on chronic diseases, including dementia, in 7983 subjects aged 55 years or older, and ongoing since 1990. The analyses were based on a random subcohort of 508 women and 438 men, and on 76 women and 53 men with incident dementia. Cox proportional hazards models with robustly estimated standard errors showed that in women higher levels of total estradiol were associated with higher risk of dementia (age-adjusted hazard ratio per standard deviation increase 1.38; 95% CI 1.04-1.84). Age-adjusted HR's of Alzheimer's disease and vascular dementia associated with higher levels of total estradiol (per SD increase) were 1.24 (95% CI 0.87-1.76) and 2.19 (95% CI 1.22-3.92), respectively. Similar results were observed for bioavailable estradiol. Additional adjustments for potential confounders did not change the results substantially. In men, no clear association was observed between estradiol levels and risk of dementia or its subtypes. The findings do not support the hypothesis that higher levels of endogenous estradiol reduce risk of dementia, neither in women nor in men. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/12730994/Endogenous_estradiol_and_risk_of_dementia_in_women_and_men:_the_Rotterdam_Study_ L2 - https://doi.org/10.1002/ana.10521 DB - PRIME DP - Unbound Medicine ER -