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Low incidence of CMV viremia and disease after allogeneic peripheral blood stem cell transplantation. Role of pretransplant ganciclovir and post-transplant acyclovir.
Bone Marrow Transplant. 2003 May; 31(9):813-6.BM

Abstract

To establish the incidence of CMV viremia after allogeneic blood stem cell transplantation, we studied 51 consecutive allogeneic peripheral blood stem cell (PBSC) transplant recipients. A total of 12 recipients were at moderate risk for CMV disease and 39 were at high risk. Conditioning regimens varied, but GvHD prophylaxis consisted of tacrolimus and mini-methotrexate in all patients. All patients received prophylactic ganciclovir from admission until day -2 and prophylactic acyclovir from day -1 until day 180 after transplantation. CMV viremia was treated with ganciclovir. Using a PCR-based technique, the cumulative incidence of CMV viremia was 31+/-14% by day 100 and 35+/-14% by day 150. Donor type, CMV risk group, underlying disorder, conditioning regimen, GvHD, and steroid use were not associated with the risk for CMV viremia. No cases of CMV disease occurred. We hypothesize that the low rate of CMV viremia and the absence of CMV disease in this cohort of PBSCT transplant recipients, which contrasts with other reports, may be related to the prophylactic use of high-dose acyclovir and possibly to pretransplant use of ganciclovir.

Authors+Show Affiliations

Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, 60637, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12732890

Citation

Verma, A, et al. "Low Incidence of CMV Viremia and Disease After Allogeneic Peripheral Blood Stem Cell Transplantation. Role of Pretransplant Ganciclovir and Post-transplant Acyclovir." Bone Marrow Transplantation, vol. 31, no. 9, 2003, pp. 813-6.
Verma A, Devine S, Morrow M, et al. Low incidence of CMV viremia and disease after allogeneic peripheral blood stem cell transplantation. Role of pretransplant ganciclovir and post-transplant acyclovir. Bone Marrow Transplant. 2003;31(9):813-6.
Verma, A., Devine, S., Morrow, M., Chen, Y. H., Mihalov, M., Peace, D., Stock, W., Pursell, K., Wickrema, A., Yassine, M., Jessop, E., & van Besien, K. (2003). Low incidence of CMV viremia and disease after allogeneic peripheral blood stem cell transplantation. Role of pretransplant ganciclovir and post-transplant acyclovir. Bone Marrow Transplantation, 31(9), 813-6.
Verma A, et al. Low Incidence of CMV Viremia and Disease After Allogeneic Peripheral Blood Stem Cell Transplantation. Role of Pretransplant Ganciclovir and Post-transplant Acyclovir. Bone Marrow Transplant. 2003;31(9):813-6. PubMed PMID: 12732890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low incidence of CMV viremia and disease after allogeneic peripheral blood stem cell transplantation. Role of pretransplant ganciclovir and post-transplant acyclovir. AU - Verma,A, AU - Devine,S, AU - Morrow,M, AU - Chen,Y-H, AU - Mihalov,M, AU - Peace,D, AU - Stock,W, AU - Pursell,K, AU - Wickrema,A, AU - Yassine,M, AU - Jessop,E, AU - van Besien,K, PY - 2003/5/7/pubmed PY - 2004/2/21/medline PY - 2003/5/7/entrez SP - 813 EP - 6 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 31 IS - 9 N2 - To establish the incidence of CMV viremia after allogeneic blood stem cell transplantation, we studied 51 consecutive allogeneic peripheral blood stem cell (PBSC) transplant recipients. A total of 12 recipients were at moderate risk for CMV disease and 39 were at high risk. Conditioning regimens varied, but GvHD prophylaxis consisted of tacrolimus and mini-methotrexate in all patients. All patients received prophylactic ganciclovir from admission until day -2 and prophylactic acyclovir from day -1 until day 180 after transplantation. CMV viremia was treated with ganciclovir. Using a PCR-based technique, the cumulative incidence of CMV viremia was 31+/-14% by day 100 and 35+/-14% by day 150. Donor type, CMV risk group, underlying disorder, conditioning regimen, GvHD, and steroid use were not associated with the risk for CMV viremia. No cases of CMV disease occurred. We hypothesize that the low rate of CMV viremia and the absence of CMV disease in this cohort of PBSCT transplant recipients, which contrasts with other reports, may be related to the prophylactic use of high-dose acyclovir and possibly to pretransplant use of ganciclovir. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/12732890/Low_incidence_of_CMV_viremia_and_disease_after_allogeneic_peripheral_blood_stem_cell_transplantation__Role_of_pretransplant_ganciclovir_and_post_transplant_acyclovir_ L2 - https://doi.org/10.1038/sj.bmt.1703916 DB - PRIME DP - Unbound Medicine ER -