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Transplants from balding and hairy androgenetic alopecia scalp regrow hair comparably well on immunodeficient mice.
J Am Acad Dermatol. 2003 May; 48(5):752-9.JA

Abstract

Human hair follicles were grafted onto 2 strains of immunodeficient mice to compare the regeneration potential of vellus (miniaturized, balding) and terminal (hairy, nonbalding) follicles from males and a female exhibiting pattern baldness. Each mouse had transplants of both types of follicles from a single donor for direct comparison. Grafted follicles from 2 male donors resulted in nonsignificant differences in mean length (52 mm vs 54 mm) and mean diameter (99 microm vs 93 microm) at 22 weeks for hairs originating from balding and hairy scalp, respectively, corresponding to 400% versus 62% of the mean pretransplantation diameters. Follicles from the female donor transplanted to several mice also resulted in nonsignificant differences in length (43 mm vs 37 mm) for hairs from balding and hairy scalp, respectively, during a period of 22 weeks. The mean diameter of the originally vellus hairs increased 3-fold, whereas the terminal hairs plateaued at approximately 50% of pretransplantation diameter, resulting in a final balding hair volume double that of the nonbalding hairs. This report shows that miniaturized hair follicles of pattern alopecia can quickly regenerate once removed from the human scalp and can grow as well as or better than terminal follicles from the same individual.

Authors+Show Affiliations

Krajcik RA
Orentreich Foundation for the Advancement of Science Inc, Cold Spring-on-Hudson, New York 10516, USA. ofas1@juno.com
Vogelman JH
No affiliation info available
Malloy VL
No affiliation info available
Orentreich N
No affiliation info available

MeSH

AdultAlopeciaAnimalsFemaleHairHair FollicleHumansMaleMiceMice, SCIDMiddle AgedTransplantation, Heterologous

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12734505

Citation

Krajcik, Rozlyn A., et al. "Transplants From Balding and Hairy Androgenetic Alopecia Scalp Regrow Hair Comparably Well On Immunodeficient Mice." Journal of the American Academy of Dermatology, vol. 48, no. 5, 2003, pp. 752-9.
Krajcik RA, Vogelman JH, Malloy VL, et al. Transplants from balding and hairy androgenetic alopecia scalp regrow hair comparably well on immunodeficient mice. J Am Acad Dermatol. 2003;48(5):752-9.
Krajcik, R. A., Vogelman, J. H., Malloy, V. L., & Orentreich, N. (2003). Transplants from balding and hairy androgenetic alopecia scalp regrow hair comparably well on immunodeficient mice. Journal of the American Academy of Dermatology, 48(5), 752-9.
Krajcik RA, et al. Transplants From Balding and Hairy Androgenetic Alopecia Scalp Regrow Hair Comparably Well On Immunodeficient Mice. J Am Acad Dermatol. 2003;48(5):752-9. PubMed PMID: 12734505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transplants from balding and hairy androgenetic alopecia scalp regrow hair comparably well on immunodeficient mice. AU - Krajcik,Rozlyn A, AU - Vogelman,Joseph H, AU - Malloy,Virginia L, AU - Orentreich,Norman, PY - 2003/5/8/pubmed PY - 2003/6/10/medline PY - 2003/5/8/entrez SP - 752 EP - 9 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 48 IS - 5 N2 - Human hair follicles were grafted onto 2 strains of immunodeficient mice to compare the regeneration potential of vellus (miniaturized, balding) and terminal (hairy, nonbalding) follicles from males and a female exhibiting pattern baldness. Each mouse had transplants of both types of follicles from a single donor for direct comparison. Grafted follicles from 2 male donors resulted in nonsignificant differences in mean length (52 mm vs 54 mm) and mean diameter (99 microm vs 93 microm) at 22 weeks for hairs originating from balding and hairy scalp, respectively, corresponding to 400% versus 62% of the mean pretransplantation diameters. Follicles from the female donor transplanted to several mice also resulted in nonsignificant differences in length (43 mm vs 37 mm) for hairs from balding and hairy scalp, respectively, during a period of 22 weeks. The mean diameter of the originally vellus hairs increased 3-fold, whereas the terminal hairs plateaued at approximately 50% of pretransplantation diameter, resulting in a final balding hair volume double that of the nonbalding hairs. This report shows that miniaturized hair follicles of pattern alopecia can quickly regenerate once removed from the human scalp and can grow as well as or better than terminal follicles from the same individual. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/12734505/Transplants_from_balding_and_hairy_androgenetic_alopecia_scalp_regrow_hair_comparably_well_on_immunodeficient_mice_ DB - PRIME DP - Unbound Medicine ER -