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Highly enantioselective reductive amination of simple aryl ketones catalyzed by Ir-f-Binaphane in the presence of titanium(IV) isopropoxide and iodine.
J Org Chem. 2003 May 16; 68(10):4120-2.JO

Abstract

Using an Ir-f-Binaphane complex as the catalyst, complete conversions and high enantioselectivies (up to 96% ee) were achieved in the asymmetric reductive amination of aryl ketones in the presence of Ti(O(i)()Pr)(4) and I(2). A simple and efficient method of synthesizing chiral primary amines has been realized.

Authors+Show Affiliations

Department of Chemistry, The Pennsylvania State University, University Park 16802, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12737606

Citation

Chi, Yongxiang, et al. "Highly Enantioselective Reductive Amination of Simple Aryl Ketones Catalyzed By Ir-f-Binaphane in the Presence of titanium(IV) Isopropoxide and Iodine." The Journal of Organic Chemistry, vol. 68, no. 10, 2003, pp. 4120-2.
Chi Y, Zhou YG, Zhang X. Highly enantioselective reductive amination of simple aryl ketones catalyzed by Ir-f-Binaphane in the presence of titanium(IV) isopropoxide and iodine. J Org Chem. 2003;68(10):4120-2.
Chi, Y., Zhou, Y. G., & Zhang, X. (2003). Highly enantioselective reductive amination of simple aryl ketones catalyzed by Ir-f-Binaphane in the presence of titanium(IV) isopropoxide and iodine. The Journal of Organic Chemistry, 68(10), 4120-2.
Chi Y, Zhou YG, Zhang X. Highly Enantioselective Reductive Amination of Simple Aryl Ketones Catalyzed By Ir-f-Binaphane in the Presence of titanium(IV) Isopropoxide and Iodine. J Org Chem. 2003 May 16;68(10):4120-2. PubMed PMID: 12737606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly enantioselective reductive amination of simple aryl ketones catalyzed by Ir-f-Binaphane in the presence of titanium(IV) isopropoxide and iodine. AU - Chi,Yongxiang, AU - Zhou,Yong-Gui, AU - Zhang,Xumu, PY - 2003/5/10/pubmed PY - 2003/12/24/medline PY - 2003/5/10/entrez SP - 4120 EP - 2 JF - The Journal of organic chemistry JO - J Org Chem VL - 68 IS - 10 N2 - Using an Ir-f-Binaphane complex as the catalyst, complete conversions and high enantioselectivies (up to 96% ee) were achieved in the asymmetric reductive amination of aryl ketones in the presence of Ti(O(i)()Pr)(4) and I(2). A simple and efficient method of synthesizing chiral primary amines has been realized. SN - 0022-3263 UR - https://www.unboundmedicine.com/medline/citation/12737606/Highly_enantioselective_reductive_amination_of_simple_aryl_ketones_catalyzed_by_Ir_f_Binaphane_in_the_presence_of_titanium_IV__isopropoxide_and_iodine_ L2 - https://doi.org/10.1021/jo026856z DB - PRIME DP - Unbound Medicine ER -