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Screening of medicinal plant extracts for antioxidant activity.

Abstract

The methanol extracts of nine medicinal plants traditionally used in Chinese medicine were screened for antioxidant activity versus resveratrol, which has been shown to protect cells from oxidative damage [Toxicol. Lett. 102 (1998) 5]. Most of the plant extracts used in this study inhibited the H(2)O(2)-induced apoptosis of Chinese hamster lung fibroblast (V79-4) cells. The extracts of Areca catechu var. dulcissima, Paeonia suffruticosa, Alpinia officinarum, Glycyrrhiza uralensis and Cinnamomun cassia strongly enhanced viability against H(2)O(2)-induced oxidative damage in V79-4 cells. Relatively high levels of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity were detected in extracts of Areca catechu var. dulcissima, Paeonia suffruticosa and Cinnamomun cassia (IC(50) < 6.0 microg/ml). The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were dose-dependently enhanced in V79-4 cells treated with most of the plant extracts. The extracts of Areca catechu var. dulcissima showed higher antioxidant activity than resveratrol in all experiments. These results suggest that the plant extracts prevent oxidative damage in normal cells probably because of their antioxidant characteristics.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, College of Dentistry, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea.

    , , ,

    Source

    Life sciences 73:2 2003 May 30 pg 167-79

    MeSH

    Animals
    Antioxidants
    Cell Division
    Cells, Cultured
    Cricetinae
    Free Radical Scavengers
    Lipid Peroxidation
    Mesocricetus
    Plant Extracts
    Plants, Medicinal
    Superoxide Dismutase

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12738032

    Citation

    Lee, Si Eun, et al. "Screening of Medicinal Plant Extracts for Antioxidant Activity." Life Sciences, vol. 73, no. 2, 2003, pp. 167-79.
    Lee SE, Hwang HJ, Ha JS, et al. Screening of medicinal plant extracts for antioxidant activity. Life Sci. 2003;73(2):167-79.
    Lee, S. E., Hwang, H. J., Ha, J. S., Jeong, H. S., & Kim, J. H. (2003). Screening of medicinal plant extracts for antioxidant activity. Life Sciences, 73(2), pp. 167-79.
    Lee SE, et al. Screening of Medicinal Plant Extracts for Antioxidant Activity. Life Sci. 2003 May 30;73(2):167-79. PubMed PMID: 12738032.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Screening of medicinal plant extracts for antioxidant activity. AU - Lee,Si Eun, AU - Hwang,Hyun Jin, AU - Ha,Jung-Sun, AU - Jeong,Han-Seung, AU - Kim,Jeong Hee, PY - 2003/5/10/pubmed PY - 2003/6/17/medline PY - 2003/5/10/entrez SP - 167 EP - 79 JF - Life sciences JO - Life Sci. VL - 73 IS - 2 N2 - The methanol extracts of nine medicinal plants traditionally used in Chinese medicine were screened for antioxidant activity versus resveratrol, which has been shown to protect cells from oxidative damage [Toxicol. Lett. 102 (1998) 5]. Most of the plant extracts used in this study inhibited the H(2)O(2)-induced apoptosis of Chinese hamster lung fibroblast (V79-4) cells. The extracts of Areca catechu var. dulcissima, Paeonia suffruticosa, Alpinia officinarum, Glycyrrhiza uralensis and Cinnamomun cassia strongly enhanced viability against H(2)O(2)-induced oxidative damage in V79-4 cells. Relatively high levels of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity were detected in extracts of Areca catechu var. dulcissima, Paeonia suffruticosa and Cinnamomun cassia (IC(50) < 6.0 microg/ml). The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were dose-dependently enhanced in V79-4 cells treated with most of the plant extracts. The extracts of Areca catechu var. dulcissima showed higher antioxidant activity than resveratrol in all experiments. These results suggest that the plant extracts prevent oxidative damage in normal cells probably because of their antioxidant characteristics. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/12738032/Screening_of_medicinal_plant_extracts_for_antioxidant_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024320503002595 DB - PRIME DP - Unbound Medicine ER -