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Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women.
Diabetologia. 2003 May; 46(5):625-33.D

Abstract

AIMS/HYPOTHESIS

Increased serum inflammatory markers have been found in obesity and insulin-resistant states, and could play a causative role in insulin resistance, atherosclerosis and cardiovascular disease. The polycystic ovary syndrome represents a human model of insulin resistance because both lean and obese polycystic ovary syndrome patients are insulin-resistant compared with non-hyperandrogenic women. We evaluated whether obesity, insulin resistance, or both, are related to the increased concentrations of inflammatory markers in pre-menopausal women.

METHODS

We compared 35 patients with polycystic ovary syndrome and 28 healthy women, paired for BMI, prevalence of obesity and smoking. Measurements included serum inflammatory markers, BMI, waist-to-hip ratio, blood pressure, serum glucose, insulin, lipid and hormone concentrations, and insulin sensitivity index.

RESULTS

The insulin sensitivity index was reduced in polycystic ovary syndrome patients compared with controls. However, no differences were observed between both groups in C-reactive protein, interleukin 6, tumour necrosis factor-alpha, soluble type 2 tumour necrosis factor receptor, and soluble intercellular cell adhesion molecule-1. When considering patients and controls as a whole, C-reactive protein and interleukin 6, were increased in obese subjects compared with lean women. Inverse correlations existed between insulin sensitivity index and C-reactive protein, interleukin 6, tumour necrosis factor-alpha, soluble type 2 tumour necrosis factor receptor, and soluble intercellular cell adhesion molecule-1. Only the weak correlation with C-reactive protein persisted after controlling for BMI.

CONCLUSION/INTERPRETATION

Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women.

Authors+Show Affiliations

Escobar-Morreale HF
Department of Endocrinology, Hospital Ramón y Cajal, Carretera de Colmenar KM 9'1, Madrid, Spain. hector.escobar@uam.es
Villuendas G
No affiliation info available
Botella-Carretero JI
No affiliation info available
Sancho J
No affiliation info available
San Millán JL
No affiliation info available

MeSH

AdultAntigens, CDBiomarkersBody Mass IndexC-Reactive ProteinCardiovascular DiseasesFemaleHumansHyperandrogenismInflammationInsulin ResistanceIntercellular Adhesion Molecule-1Interleukin-6ObesityPolycystic Ovary SyndromeReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IIReference ValuesTumor Necrosis Factor-alpha

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12739017

Citation

Escobar-Morreale, H F., et al. "Obesity, and Not Insulin Resistance, Is the Major Determinant of Serum Inflammatory Cardiovascular Risk Markers in Pre-menopausal Women." Diabetologia, vol. 46, no. 5, 2003, pp. 625-33.
Escobar-Morreale HF, Villuendas G, Botella-Carretero JI, et al. Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women. Diabetologia. 2003;46(5):625-33.
Escobar-Morreale, H. F., Villuendas, G., Botella-Carretero, J. I., Sancho, J., & San Millán, J. L. (2003). Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women. Diabetologia, 46(5), 625-33.
Escobar-Morreale HF, et al. Obesity, and Not Insulin Resistance, Is the Major Determinant of Serum Inflammatory Cardiovascular Risk Markers in Pre-menopausal Women. Diabetologia. 2003;46(5):625-33. PubMed PMID: 12739017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women. AU - Escobar-Morreale,H F, AU - Villuendas,G, AU - Botella-Carretero,J I, AU - Sancho,J, AU - San Millán,J L, Y1 - 2003/05/09/ PY - 2002/11/08/received PY - 2002/12/18/revised PY - 2003/5/10/pubmed PY - 2004/3/31/medline PY - 2003/5/10/entrez SP - 625 EP - 33 JF - Diabetologia JO - Diabetologia VL - 46 IS - 5 N2 - AIMS/HYPOTHESIS: Increased serum inflammatory markers have been found in obesity and insulin-resistant states, and could play a causative role in insulin resistance, atherosclerosis and cardiovascular disease. The polycystic ovary syndrome represents a human model of insulin resistance because both lean and obese polycystic ovary syndrome patients are insulin-resistant compared with non-hyperandrogenic women. We evaluated whether obesity, insulin resistance, or both, are related to the increased concentrations of inflammatory markers in pre-menopausal women. METHODS: We compared 35 patients with polycystic ovary syndrome and 28 healthy women, paired for BMI, prevalence of obesity and smoking. Measurements included serum inflammatory markers, BMI, waist-to-hip ratio, blood pressure, serum glucose, insulin, lipid and hormone concentrations, and insulin sensitivity index. RESULTS: The insulin sensitivity index was reduced in polycystic ovary syndrome patients compared with controls. However, no differences were observed between both groups in C-reactive protein, interleukin 6, tumour necrosis factor-alpha, soluble type 2 tumour necrosis factor receptor, and soluble intercellular cell adhesion molecule-1. When considering patients and controls as a whole, C-reactive protein and interleukin 6, were increased in obese subjects compared with lean women. Inverse correlations existed between insulin sensitivity index and C-reactive protein, interleukin 6, tumour necrosis factor-alpha, soluble type 2 tumour necrosis factor receptor, and soluble intercellular cell adhesion molecule-1. Only the weak correlation with C-reactive protein persisted after controlling for BMI. CONCLUSION/INTERPRETATION: Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/12739017/Obesity_and_not_insulin_resistance_is_the_major_determinant_of_serum_inflammatory_cardiovascular_risk_markers_in_pre_menopausal_women_ DB - PRIME DP - Unbound Medicine ER -