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Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy.
Acta Pharmacol Sin. 2003 May; 24(5):467-71.AP

Abstract

AIM

To study the effect of Ginkgo biloba extract (GbE) on acute cerebral ischemia in rats.

METHODS

The rats were randomly divided into four groups: sham-operated group (group I as control), ischemic group (group II), the prophylactic (GbE premedication) group (group III) and GbE-treatment group (group IV). Magnetic resonance spectroscopy (MRS) was carried out to dynamically monitor the changes in biochemical metabolic variations 48 h after cerebral ischemia and effects of GbE (100 mg/kg, ip, qd).

RESULTS

(1) Lactate (Lac) peak could be detectable at the infarction area 90 min after acute cerebral ischemia and increased with time. Lac peak in the prophylactic group was elevated slightly (P<0.01, n=6), whereas in the treatment group the elevation of Lac was more remarkable than that in the prophylactic group (P<0.05, n=6). (2) In the ischemic group, the level of N-acetyl aspartate (NAA) was decreased within 4 h after ischemia (P<0.05, n=6), and the decline persisted (P<0.01, n=6). In the treatment group and prophylactic group, NAA was decreased slightly after 24 h (P<0.05, n=6). (3)Twenty-four hours after ischemia, in both ischemic group and treatment group, choline (Cho) was elevated slightly (P<0.05, n=6) and creatine (Cr) was decreased slightly (P<0.05, n=6), but in the prophylactic group these changes occurred only after 48 h.

CONCLUSION

GbE could prevent and treat acute cerebral ischemia. The effectiveness was more satisfactory when GbE was used preventively.

Authors+Show Affiliations

Department of Neurology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. penghai493@sohu.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12740184

Citation

Peng, Hai, et al. "Effects of Ginkgo Biloba Extract On Acute Cerebral Ischemia in Rats Analyzed By Magnetic Resonance Spectroscopy." Acta Pharmacologica Sinica, vol. 24, no. 5, 2003, pp. 467-71.
Peng H, Li YF, Sun SG. Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy. Acta Pharmacol Sin. 2003;24(5):467-71.
Peng, H., Li, Y. F., & Sun, S. G. (2003). Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy. Acta Pharmacologica Sinica, 24(5), 467-71.
Peng H, Li YF, Sun SG. Effects of Ginkgo Biloba Extract On Acute Cerebral Ischemia in Rats Analyzed By Magnetic Resonance Spectroscopy. Acta Pharmacol Sin. 2003;24(5):467-71. PubMed PMID: 12740184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy. AU - Peng,Hai, AU - Li,Yue-Fen, AU - Sun,Sheng-Gang, PY - 2003/5/13/pubmed PY - 2003/10/8/medline PY - 2003/5/13/entrez SP - 467 EP - 71 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 24 IS - 5 N2 - AIM: To study the effect of Ginkgo biloba extract (GbE) on acute cerebral ischemia in rats. METHODS: The rats were randomly divided into four groups: sham-operated group (group I as control), ischemic group (group II), the prophylactic (GbE premedication) group (group III) and GbE-treatment group (group IV). Magnetic resonance spectroscopy (MRS) was carried out to dynamically monitor the changes in biochemical metabolic variations 48 h after cerebral ischemia and effects of GbE (100 mg/kg, ip, qd). RESULTS: (1) Lactate (Lac) peak could be detectable at the infarction area 90 min after acute cerebral ischemia and increased with time. Lac peak in the prophylactic group was elevated slightly (P<0.01, n=6), whereas in the treatment group the elevation of Lac was more remarkable than that in the prophylactic group (P<0.05, n=6). (2) In the ischemic group, the level of N-acetyl aspartate (NAA) was decreased within 4 h after ischemia (P<0.05, n=6), and the decline persisted (P<0.01, n=6). In the treatment group and prophylactic group, NAA was decreased slightly after 24 h (P<0.05, n=6). (3)Twenty-four hours after ischemia, in both ischemic group and treatment group, choline (Cho) was elevated slightly (P<0.05, n=6) and creatine (Cr) was decreased slightly (P<0.05, n=6), but in the prophylactic group these changes occurred only after 48 h. CONCLUSION: GbE could prevent and treat acute cerebral ischemia. The effectiveness was more satisfactory when GbE was used preventively. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/12740184/Effects_of_Ginkgo_biloba_extract_on_acute_cerebral_ischemia_in_rats_analyzed_by_magnetic_resonance_spectroscopy_ L2 - http://www.chinaphar.com/1671-4083/24/467.pdf DB - PRIME DP - Unbound Medicine ER -