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Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patients.
Exp Gerontol 2003; 38(5):589-95EG

Abstract

Patients with autoimmune thyroiditis (AT) have an increased prevalence of coeliac disease (CD), an immune-mediated enteropathy. It is unknown, however, whether prevalence of CD in AT is affected by age. Sera from 514 patients with AT aged <65 yr (46+/-12 yr), 223 patients with AT aged >or=65 yr (71+/-5 yr), 300 controls aged <65 yr (45+/-12 yr), and 300 controls aged >or=65 yr (71+/-6 yr) were tested for IgA anti-tissue transglutaminase (anti-tTG) and antiendomysial antibodies (EmA). If anti-tTG or EmA IgA were positive, jejunal biopsy was performed to confirm CD diagnosis. Prevalence of CD was significantly higher in patients with AT aged >or=65 yr (3.6%, P=0.024) than in patients with AT aged <65 yr (0.6%), controls aged <65 yr and controls aged >or=65 yr (both 0.3%). Prevalence of CD did not significantly differ across patients with AT aged <65 yr, controls aged <65 yr and controls aged >or=65 yr. In conclusion, prevalence of CD is increased in AT but the association is limited to patients aged 65 years or older. Serological screening including anti-tTG-IgA is recommended in these patients.

Authors+Show Affiliations

Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S. Orsola-Malpighi, Via Massarenti, 9, Bologna 40138, Italy. ravaglia@almadns.unibo.it

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12742537

Citation

Ravaglia, Giovanni, et al. "Increased Prevalence of Coeliac Disease in Autoimmune Thyroiditis Is Restricted to Aged Patients." Experimental Gerontology, vol. 38, no. 5, 2003, pp. 589-95.
Ravaglia G, Forti P, Maioli F, et al. Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patients. Exp Gerontol. 2003;38(5):589-95.
Ravaglia, G., Forti, P., Maioli, F., Volta, U., Arnone, G., Pantieri, G., ... Zoli, M. (2003). Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patients. Experimental Gerontology, 38(5), pp. 589-95.
Ravaglia G, et al. Increased Prevalence of Coeliac Disease in Autoimmune Thyroiditis Is Restricted to Aged Patients. Exp Gerontol. 2003;38(5):589-95. PubMed PMID: 12742537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patients. AU - Ravaglia,Giovanni, AU - Forti,Paola, AU - Maioli,Fabiola, AU - Volta,Umberto, AU - Arnone,Giorgia, AU - Pantieri,Gaia, AU - Talerico,Teresa, AU - Muscari,Antonio, AU - Zoli,Marco, PY - 2003/5/14/pubmed PY - 2003/10/8/medline PY - 2003/5/14/entrez SP - 589 EP - 95 JF - Experimental gerontology JO - Exp. Gerontol. VL - 38 IS - 5 N2 - Patients with autoimmune thyroiditis (AT) have an increased prevalence of coeliac disease (CD), an immune-mediated enteropathy. It is unknown, however, whether prevalence of CD in AT is affected by age. Sera from 514 patients with AT aged <65 yr (46+/-12 yr), 223 patients with AT aged >or=65 yr (71+/-5 yr), 300 controls aged <65 yr (45+/-12 yr), and 300 controls aged >or=65 yr (71+/-6 yr) were tested for IgA anti-tissue transglutaminase (anti-tTG) and antiendomysial antibodies (EmA). If anti-tTG or EmA IgA were positive, jejunal biopsy was performed to confirm CD diagnosis. Prevalence of CD was significantly higher in patients with AT aged >or=65 yr (3.6%, P=0.024) than in patients with AT aged <65 yr (0.6%), controls aged <65 yr and controls aged >or=65 yr (both 0.3%). Prevalence of CD did not significantly differ across patients with AT aged <65 yr, controls aged <65 yr and controls aged >or=65 yr. In conclusion, prevalence of CD is increased in AT but the association is limited to patients aged 65 years or older. Serological screening including anti-tTG-IgA is recommended in these patients. SN - 0531-5565 UR - https://www.unboundmedicine.com/medline/citation/12742537/Increased_prevalence_of_coeliac_disease_in_autoimmune_thyroiditis_is_restricted_to_aged_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531556503000378 DB - PRIME DP - Unbound Medicine ER -