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Kv1.2-immunoreactive primary sensory neurons in the rat trigeminal ganglion.
Brain Res. 2003 Jun 06; 974(1-2):222-7.BR

Abstract

Immunohistochemistry for Kv1.2, a subunit of voltage-gated K(+) channels, was performed on the trigeminal ganglion (TG). Immunoreactivity (ir) was detected in half (48%) the TG neurons. These neurons were mostly medium-sized to large (range 137.6-2664.8 microm(2), mean+/-S.D. 892.6+/-413.3 microm(2)). A double immunofluorescence method also revealed co-expression of Kv1.2 and parvalbumin. Half (54%) the Kv1.2-immunoreactive (ir) neurons exhibited parvalbumin-ir, and parvalbumin-ir neurons mostly showed Kv1.2-ir (95%). Kv1.2-ir neurons which co-expressed CGRP-ir were rare in this ganglion. Some 40% of TG neurons retrogradely labeled from the facial skin exhibited Kv1.2-ir, whereas ir was detected in 16% of those labeled from the tooth pulp. The present study indicates that Kv1.2-ir TG neurons include low-threshold mechanoreceptors and nociceptors which innervate the facial skin and tooth pulp, respectively.

Authors+Show Affiliations

Department of Oral Anatomy and Function, and Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Japan. hiroichi@md.okayama-u.ac.jpNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12742640

Citation

Ichikawa, Hiroyuki, and Tomosada Sugimoto. "Kv1.2-immunoreactive Primary Sensory Neurons in the Rat Trigeminal Ganglion." Brain Research, vol. 974, no. 1-2, 2003, pp. 222-7.
Ichikawa H, Sugimoto T. Kv1.2-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Res. 2003;974(1-2):222-7.
Ichikawa, H., & Sugimoto, T. (2003). Kv1.2-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Research, 974(1-2), 222-7.
Ichikawa H, Sugimoto T. Kv1.2-immunoreactive Primary Sensory Neurons in the Rat Trigeminal Ganglion. Brain Res. 2003 Jun 6;974(1-2):222-7. PubMed PMID: 12742640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kv1.2-immunoreactive primary sensory neurons in the rat trigeminal ganglion. AU - Ichikawa,Hiroyuki, AU - Sugimoto,Tomosada, PY - 2003/5/14/pubmed PY - 2003/7/23/medline PY - 2003/5/14/entrez SP - 222 EP - 7 JF - Brain research JO - Brain Res. VL - 974 IS - 1-2 N2 - Immunohistochemistry for Kv1.2, a subunit of voltage-gated K(+) channels, was performed on the trigeminal ganglion (TG). Immunoreactivity (ir) was detected in half (48%) the TG neurons. These neurons were mostly medium-sized to large (range 137.6-2664.8 microm(2), mean+/-S.D. 892.6+/-413.3 microm(2)). A double immunofluorescence method also revealed co-expression of Kv1.2 and parvalbumin. Half (54%) the Kv1.2-immunoreactive (ir) neurons exhibited parvalbumin-ir, and parvalbumin-ir neurons mostly showed Kv1.2-ir (95%). Kv1.2-ir neurons which co-expressed CGRP-ir were rare in this ganglion. Some 40% of TG neurons retrogradely labeled from the facial skin exhibited Kv1.2-ir, whereas ir was detected in 16% of those labeled from the tooth pulp. The present study indicates that Kv1.2-ir TG neurons include low-threshold mechanoreceptors and nociceptors which innervate the facial skin and tooth pulp, respectively. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/12742640/Kv1_2_immunoreactive_primary_sensory_neurons_in_the_rat_trigeminal_ganglion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006899303025836 DB - PRIME DP - Unbound Medicine ER -