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Association of emphysema, gout, and inflammatory markers with long-term incidence of age-related maculopathy.
Arch Ophthalmol. 2003 May; 121(5):674-8.AO

Abstract

OBJECTIVE

To examine the relationship of 2 diseases associated with systemic inflammatory response, emphysema and gout, and selected markers of systemic inflammation with the 10-year incidence of age-related maculopathy.

DESIGN

Population-based cohort study.

PARTICIPANTS

We included persons aged 43 to 86 years at baseline examination from 1988 to 1990 living in Beaver Dam, Wis, of whom 3684 subjects participated in a 5-year follow-up examination and 2764 participated in a 10-year follow-up.

METHODS

Standardized protocols for physical examination, blood collection, administration of a questionnaire, and stereoscopic color fundus photography to determine the presence of age-related maculopathy. Standard univariate and multivariate analyses were performed.

MAIN OUTCOME MEASURES

Incidence and progression of age-related maculopathy.

RESULTS

While controlling for age, sex, and other factors (history of heavy drinking or smoking, systolic blood pressure, and vitamin use), a higher white blood cell count at baseline was associated with the 10-year incidence of drusen 125 microm or greater in diameter (risk ratio [RR] per 10(6)/ microL = 1.10; 95% confidence interval [CI], 1.03-1.17), retinal pigment epithelial depigmentation (RR = 2.08; 95% CI, 1.01-1.16), and progression of age-related maculopathy (RR = 1.09; 95% CI, 1.03-1.15). A lower serum albumin level was associated with the incidence of exudative macular degeneration (RR per grams per deciliter = 0.31; 95% CI, 0.13-0.76). A history of emphysema at baseline was associated with the incidence of retinal pigment epithelial depigmentation (RR = 2.84; 95% CI, 1.40-5.78), increased retinal pigment (RR = 2.20; 95% CI, 1.11-4.35), and exudative macular degeneration (RR = 5.12; 95% CI, 1.63-16.06); a history of gout was associated with the incidence of pure geographic atrophy (RR = 3.48; 95% CI, 1.27-9.53).

CONCLUSIONS

These findings indicate modest relationships between both increased white blood cell count and emphysema and the increased 10-year incidence of lesions defining early and late age-related maculopathy. Further investigation of these relationships in other studies is needed.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, 53726-2397, USA. kleinr@epi.ophth.wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12742845

Citation

Klein, Ronald, et al. "Association of Emphysema, Gout, and Inflammatory Markers With Long-term Incidence of Age-related Maculopathy." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 121, no. 5, 2003, pp. 674-8.
Klein R, Klein BE, Tomany SC, et al. Association of emphysema, gout, and inflammatory markers with long-term incidence of age-related maculopathy. Arch Ophthalmol. 2003;121(5):674-8.
Klein, R., Klein, B. E., Tomany, S. C., & Cruickshanks, K. J. (2003). Association of emphysema, gout, and inflammatory markers with long-term incidence of age-related maculopathy. Archives of Ophthalmology (Chicago, Ill. : 1960), 121(5), 674-8.
Klein R, et al. Association of Emphysema, Gout, and Inflammatory Markers With Long-term Incidence of Age-related Maculopathy. Arch Ophthalmol. 2003;121(5):674-8. PubMed PMID: 12742845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of emphysema, gout, and inflammatory markers with long-term incidence of age-related maculopathy. AU - Klein,Ronald, AU - Klein,Barbara E K, AU - Tomany,Sandra C, AU - Cruickshanks,Karen J, PY - 2003/5/14/pubmed PY - 2003/6/5/medline PY - 2003/5/14/entrez SP - 674 EP - 8 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch Ophthalmol VL - 121 IS - 5 N2 - OBJECTIVE: To examine the relationship of 2 diseases associated with systemic inflammatory response, emphysema and gout, and selected markers of systemic inflammation with the 10-year incidence of age-related maculopathy. DESIGN: Population-based cohort study. PARTICIPANTS: We included persons aged 43 to 86 years at baseline examination from 1988 to 1990 living in Beaver Dam, Wis, of whom 3684 subjects participated in a 5-year follow-up examination and 2764 participated in a 10-year follow-up. METHODS: Standardized protocols for physical examination, blood collection, administration of a questionnaire, and stereoscopic color fundus photography to determine the presence of age-related maculopathy. Standard univariate and multivariate analyses were performed. MAIN OUTCOME MEASURES: Incidence and progression of age-related maculopathy. RESULTS: While controlling for age, sex, and other factors (history of heavy drinking or smoking, systolic blood pressure, and vitamin use), a higher white blood cell count at baseline was associated with the 10-year incidence of drusen 125 microm or greater in diameter (risk ratio [RR] per 10(6)/ microL = 1.10; 95% confidence interval [CI], 1.03-1.17), retinal pigment epithelial depigmentation (RR = 2.08; 95% CI, 1.01-1.16), and progression of age-related maculopathy (RR = 1.09; 95% CI, 1.03-1.15). A lower serum albumin level was associated with the incidence of exudative macular degeneration (RR per grams per deciliter = 0.31; 95% CI, 0.13-0.76). A history of emphysema at baseline was associated with the incidence of retinal pigment epithelial depigmentation (RR = 2.84; 95% CI, 1.40-5.78), increased retinal pigment (RR = 2.20; 95% CI, 1.11-4.35), and exudative macular degeneration (RR = 5.12; 95% CI, 1.63-16.06); a history of gout was associated with the incidence of pure geographic atrophy (RR = 3.48; 95% CI, 1.27-9.53). CONCLUSIONS: These findings indicate modest relationships between both increased white blood cell count and emphysema and the increased 10-year incidence of lesions defining early and late age-related maculopathy. Further investigation of these relationships in other studies is needed. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/12742845/Association_of_emphysema_gout_and_inflammatory_markers_with_long_term_incidence_of_age_related_maculopathy_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/121/pg/674 DB - PRIME DP - Unbound Medicine ER -