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Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis.
Parasitol Res. 2003 05; 90(1):71-9.PR

Abstract

Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, has remained a disease with no effective treatment. Recent progress in HAT research suggests that a vaccine against the disease is far from being successful. Also the emergence of drug-resistant trypanosomes makes further work in this area imperative. So far the treatment for the early stage of HAT involves the drugs pentamidine and suramin which have been very successful. In the second stage of the disease, during which the trypanosomes reside in the cerebrospinal fluid (CSF), treatment is dependent exclusively on the arsenical compound melarsoprol. This is largely due to the inability to find compounds that can cross the blood brain barrier and kill the CSF-residing trypanosomes. This review summarises our current understanding on the treatment of HAT.

Authors+Show Affiliations

Nok AJ
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria. jandrew@skannet.com

MeSH

AnimalsDrug ResistanceHIVHumansMelarsoprolPentamidineSuraminTrypanocidal AgentsTrypanosoma brucei gambienseTrypanosoma brucei rhodesienseTrypanosomiasis, African

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12743807

Citation

Nok, Andrew Jonathan. "Arsenicals (melarsoprol), Pentamidine and Suramin in the Treatment of Human African Trypanosomiasis." Parasitology Research, vol. 90, no. 1, 2003, pp. 71-9.
Nok AJ. Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. Parasitol Res. 2003;90(1):71-9.
Nok, A. J. (2003). Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. Parasitology Research, 90(1), 71-9.
Nok AJ. Arsenicals (melarsoprol), Pentamidine and Suramin in the Treatment of Human African Trypanosomiasis. Parasitol Res. 2003;90(1):71-9. PubMed PMID: 12743807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. A1 - Nok,Andrew Jonathan, Y1 - 2003/01/31/ PY - 2002/10/23/received PY - 2002/10/31/accepted PY - 2003/5/14/pubmed PY - 2003/8/12/medline PY - 2003/5/14/entrez SP - 71 EP - 9 JF - Parasitology research JO - Parasitol Res VL - 90 IS - 1 N2 - Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, has remained a disease with no effective treatment. Recent progress in HAT research suggests that a vaccine against the disease is far from being successful. Also the emergence of drug-resistant trypanosomes makes further work in this area imperative. So far the treatment for the early stage of HAT involves the drugs pentamidine and suramin which have been very successful. In the second stage of the disease, during which the trypanosomes reside in the cerebrospinal fluid (CSF), treatment is dependent exclusively on the arsenical compound melarsoprol. This is largely due to the inability to find compounds that can cross the blood brain barrier and kill the CSF-residing trypanosomes. This review summarises our current understanding on the treatment of HAT. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/12743807/Arsenicals__melarsoprol__pentamidine_and_suramin_in_the_treatment_of_human_African_trypanosomiasis_ DB - PRIME DP - Unbound Medicine ER -