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The comparison of antibody response to influenza vaccination in continuous ambulatory peritoneal dialysis, hemodialysis and renal transplantation patients.
Scand J Urol Nephrol. 2003; 37(1):71-6.SJ

Abstract

BACKGROUND

The immune system in renal transplant (Tx), Continuous Ambulatory Peritoneal Dialysis (CAPD) and hemodialysis (HD) patients have been suppressed and antibody response to vaccination is weaker than that of the normal population. Additionally immune response to vaccination also differs from each other in aforementioned three groups resulting from different levels immunosuppression. In the present study, detection of antibody response to influenza vaccine as an indicator of the level of immunity in Tx, CAPD and HD patients was aimed

PATIENTS AND METHODS

Forty-eight patients (17 Tx, 16 CAPD and 15 HD) and 10 healthy adults, as a control group were enrolled into the study. Purified, split-virus, commercial trivalent influenza vaccine (VAXIGRIP--Pasteur Merieux Connaught, single dose of 0.5 ml into the deltoid muscle) containing 15 microg of each hemagglutinin of A/Johannesburg/82/96 (H1N1), A/Nachang/933/95 (H3N2) and B/Harbin/07/94 (B) strains were administered to all subjects. Serum samples were collected before and 1 month after vaccination to determine antibody titers. Hemagglutination-inhibition test (HI) was applied for determination of antibody response. The antibody response against each strain was measured separately. In addition to measurement of antibody response, increments in antibody titer (n-fold increase in titer), proportion of patients with protective antibody levels and seroconversion levels were taken into account. Wilcoxon paired 2 test and Mann-Whitney U test were applied for statistical analysis. p < 0.05 was accepted as significance level.

RESULTS

Significant increases in antibody titers for all three antigens were observed in the study groups after vaccination (p = 0.001). However, the increase in titer of H3N2 was lower in Tx, CAPD and HD patients than that of the control group (1.0-2.0 vs 5.00) (p = 0.01). The proportion of protective antibody titers and seroconvertions were increased after vaccination in all subjects. Proportions of patients with protective antibody titers after vaccination were lower in Tx, CAPD and HD groups in comparison to control group.

CONCLUSION

Although antibody titers in Tx, CAPD and HD patients presented significant increases after vaccination, the proportions of patients with protective antibody titers were lower in comparison to control group. Tx, CAPD and HD patients should be vaccinated every year to be able avoid potential morbidity and mortality of the influenza infection. Trial of high dose vaccination protocols may be useful to increase the proportion of patients with protective antibody levels.

Authors+Show Affiliations

Cavdar C
Department of Nephrology, Dokuz Eylül University, Izmir, Turkey. caner.cavdar@deu.edu.tr
Sayan M
No affiliation info available
Sifil A
No affiliation info available
Artuk C
No affiliation info available
Yilmaz N
No affiliation info available
Bahar H
No affiliation info available
Camsari T
No affiliation info available

MeSH

AdultAgedAntibody FormationFemaleHumansImmunity, ActiveInfluenza VaccinesInfluenza, HumanKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPeritoneal Dialysis, Continuous AmbulatoryRenal Dialysis

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12745749

Clinical Trial Links

Impact of Immunosuppression in IBD Patients on Response to Influenza Vaccine
Influenza Vaccination in Immunocompromized Patients

Citation

Cavdar, Caner, et al. "The Comparison of Antibody Response to Influenza Vaccination in Continuous Ambulatory Peritoneal Dialysis, Hemodialysis and Renal Transplantation Patients." Scandinavian Journal of Urology and Nephrology, vol. 37, no. 1, 2003, pp. 71-6.
Cavdar C, Sayan M, Sifil A, et al. The comparison of antibody response to influenza vaccination in continuous ambulatory peritoneal dialysis, hemodialysis and renal transplantation patients. Scand J Urol Nephrol. 2003;37(1):71-6.
Cavdar, C., Sayan, M., Sifil, A., Artuk, C., Yilmaz, N., Bahar, H., & Camsari, T. (2003). The comparison of antibody response to influenza vaccination in continuous ambulatory peritoneal dialysis, hemodialysis and renal transplantation patients. Scandinavian Journal of Urology and Nephrology, 37(1), 71-6.
Cavdar C, et al. The Comparison of Antibody Response to Influenza Vaccination in Continuous Ambulatory Peritoneal Dialysis, Hemodialysis and Renal Transplantation Patients. Scand J Urol Nephrol. 2003;37(1):71-6. PubMed PMID: 12745749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The comparison of antibody response to influenza vaccination in continuous ambulatory peritoneal dialysis, hemodialysis and renal transplantation patients. AU - Cavdar,Caner, AU - Sayan,Murat, AU - Sifil,Aykut, AU - Artuk,Cigdem, AU - Yilmaz,Nezihe, AU - Bahar,Hakki, AU - Camsari,Taner, PY - 2003/5/15/pubmed PY - 2003/6/11/medline PY - 2003/5/15/entrez SP - 71 EP - 6 JF - Scandinavian journal of urology and nephrology JO - Scand J Urol Nephrol VL - 37 IS - 1 N2 - BACKGROUND: The immune system in renal transplant (Tx), Continuous Ambulatory Peritoneal Dialysis (CAPD) and hemodialysis (HD) patients have been suppressed and antibody response to vaccination is weaker than that of the normal population. Additionally immune response to vaccination also differs from each other in aforementioned three groups resulting from different levels immunosuppression. In the present study, detection of antibody response to influenza vaccine as an indicator of the level of immunity in Tx, CAPD and HD patients was aimed PATIENTS AND METHODS: Forty-eight patients (17 Tx, 16 CAPD and 15 HD) and 10 healthy adults, as a control group were enrolled into the study. Purified, split-virus, commercial trivalent influenza vaccine (VAXIGRIP--Pasteur Merieux Connaught, single dose of 0.5 ml into the deltoid muscle) containing 15 microg of each hemagglutinin of A/Johannesburg/82/96 (H1N1), A/Nachang/933/95 (H3N2) and B/Harbin/07/94 (B) strains were administered to all subjects. Serum samples were collected before and 1 month after vaccination to determine antibody titers. Hemagglutination-inhibition test (HI) was applied for determination of antibody response. The antibody response against each strain was measured separately. In addition to measurement of antibody response, increments in antibody titer (n-fold increase in titer), proportion of patients with protective antibody levels and seroconversion levels were taken into account. Wilcoxon paired 2 test and Mann-Whitney U test were applied for statistical analysis. p < 0.05 was accepted as significance level. RESULTS: Significant increases in antibody titers for all three antigens were observed in the study groups after vaccination (p = 0.001). However, the increase in titer of H3N2 was lower in Tx, CAPD and HD patients than that of the control group (1.0-2.0 vs 5.00) (p = 0.01). The proportion of protective antibody titers and seroconvertions were increased after vaccination in all subjects. Proportions of patients with protective antibody titers after vaccination were lower in Tx, CAPD and HD groups in comparison to control group. CONCLUSION: Although antibody titers in Tx, CAPD and HD patients presented significant increases after vaccination, the proportions of patients with protective antibody titers were lower in comparison to control group. Tx, CAPD and HD patients should be vaccinated every year to be able avoid potential morbidity and mortality of the influenza infection. Trial of high dose vaccination protocols may be useful to increase the proportion of patients with protective antibody levels. SN - 0036-5599 UR - https://www.unboundmedicine.com/medline/citation/12745749/The_comparison_of_antibody_response_to_influenza_vaccination_in_continuous_ambulatory_peritoneal_dialysis_hemodialysis_and_renal_transplantation_patients_ DB - PRIME DP - Unbound Medicine ER -