Tags

Type your tag names separated by a space and hit enter

[Early response to oral cobalamin therapy in older patients with vitamin B12 deficiency].
Ann Med Interne (Paris). 2003 Mar; 154(2):91-5.AM

Abstract

PURPOSE

Standard treatment of vitamin B12 deficiency involves regular intramuscular cobalamin administration. The aim of this study was to determine whether oral cobalamin treatment may be an effective therapy for treating older patients with cobalamin deficiency related to nutritional deficiency and food-cobalamin malabsorption.

PATIENTS AND METHODS

We prospectively studied 20 patients older than 80 years with established cobalamin deficiency related to food-cobalamin malabsorption (n=14) and nutritional deficiency (n=6) who received 1000 micro g of oral cyanocobalamin per day. Levels of serum cobalamin and blood counts were determined at baseline and after the first week of treatment.

RESULTS

After an average of 8 days of treatment, 17 out of 20 patients normalized their serum cobalamin levels; the patients had increased their serum cobalamin level (mean increase of 0.23 micro g/L; p<0.01 compared with baseline), reticulocyte count (mean increase of 27400/mm(3); p<0.05), hemoglobin levels (mean increase of 0.7 g/dL; NS), and decreased the mean erythrocyte volume (mean decrease of 0.7 fL; NS).

CONCLUSION

Our findings suggest that cyanocobalamin given orally during one week may be an effective treatment for cobalamin deficiency related to food-cobalamin malabsorption and nutritional deficiency and may avoid painful intra-muscular injections in older patients.

Authors+Show Affiliations

Kaltenbach G
Centre de Gérontologie, Hôpital de la Robertsau-Hôpitaux Universitaires, 83, rue Himmerich, 67000 Strasbourg. georges.kaltenbach@chru-strasbourg.fr
Noblet-Dick M
No affiliation info available
Andrès E
No affiliation info available
Barnier-Figue G
No affiliation info available
Noel E
No affiliation info available
Vogel T
No affiliation info available
Perrin AE
No affiliation info available
Martin-Hunyadi C
No affiliation info available
Berthel M
No affiliation info available
Kuntzmann F
No affiliation info available

MeSH

Administration, OralAgedAged, 80 and overErythrocyte VolumeFemaleHemoglobinsHumansMalabsorption SyndromesMaleProspective StudiesReference ValuesReticulocyte CountVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

12746645

Citation

Kaltenbach, Georges, et al. "[Early Response to Oral Cobalamin Therapy in Older Patients With Vitamin B12 Deficiency]." Annales De Medecine Interne, vol. 154, no. 2, 2003, pp. 91-5.
Kaltenbach G, Noblet-Dick M, Andrès E, et al. [Early response to oral cobalamin therapy in older patients with vitamin B12 deficiency]. Ann Med Interne (Paris). 2003;154(2):91-5.
Kaltenbach, G., Noblet-Dick, M., Andrès, E., Barnier-Figue, G., Noel, E., Vogel, T., Perrin, A. E., Martin-Hunyadi, C., Berthel, M., & Kuntzmann, F. (2003). [Early response to oral cobalamin therapy in older patients with vitamin B12 deficiency]. Annales De Medecine Interne, 154(2), 91-5.
Kaltenbach G, et al. [Early Response to Oral Cobalamin Therapy in Older Patients With Vitamin B12 Deficiency]. Ann Med Interne (Paris). 2003;154(2):91-5. PubMed PMID: 12746645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Early response to oral cobalamin therapy in older patients with vitamin B12 deficiency]. AU - Kaltenbach,Georges, AU - Noblet-Dick,Marie, AU - Andrès,Emmanuel, AU - Barnier-Figue,Geneviève, AU - Noel,Ester, AU - Vogel,Thomas, AU - Perrin,Anne-Elisabeth, AU - Martin-Hunyadi,Catherine, AU - Berthel,Marc, AU - Kuntzmann,Francis, PY - 2003/5/15/pubmed PY - 2003/8/2/medline PY - 2003/5/15/entrez SP - 91 EP - 5 JF - Annales de medecine interne JO - Ann Med Interne (Paris) VL - 154 IS - 2 N2 - PURPOSE: Standard treatment of vitamin B12 deficiency involves regular intramuscular cobalamin administration. The aim of this study was to determine whether oral cobalamin treatment may be an effective therapy for treating older patients with cobalamin deficiency related to nutritional deficiency and food-cobalamin malabsorption. PATIENTS AND METHODS: We prospectively studied 20 patients older than 80 years with established cobalamin deficiency related to food-cobalamin malabsorption (n=14) and nutritional deficiency (n=6) who received 1000 micro g of oral cyanocobalamin per day. Levels of serum cobalamin and blood counts were determined at baseline and after the first week of treatment. RESULTS: After an average of 8 days of treatment, 17 out of 20 patients normalized their serum cobalamin levels; the patients had increased their serum cobalamin level (mean increase of 0.23 micro g/L; p<0.01 compared with baseline), reticulocyte count (mean increase of 27400/mm(3); p<0.05), hemoglobin levels (mean increase of 0.7 g/dL; NS), and decreased the mean erythrocyte volume (mean decrease of 0.7 fL; NS). CONCLUSION: Our findings suggest that cyanocobalamin given orally during one week may be an effective treatment for cobalamin deficiency related to food-cobalamin malabsorption and nutritional deficiency and may avoid painful intra-muscular injections in older patients. SN - 0003-410X UR - https://www.unboundmedicine.com/medline/citation/12746645/[Early_response_to_oral_cobalamin_therapy_in_older_patients_with_vitamin_B12_deficiency]_ DB - PRIME DP - Unbound Medicine ER -