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[Clinical presentation and management of the severe acute respiratory syndrome (SARS)].
Dtsch Med Wochenschr. 2003 May 16; 128(20):1109-14.DM

Abstract

BACKGROUND AND OBJECTIVE

In February 2003, a newly emerged infectious disease was described, the etiology of which was initially unknown. It is referred to under the term SARS. In the beginning, it spread in some regions South-East Asia. Import infections appeared in many other parts of the world. Based on the first cases in Germany, this report illustrates the clinical appearance, the diagnostic results and the management of this new disease.

PATIENTS AND METHODS

We analysed the data of two patients with SARS and one suspected patient. The results of radiological, laboratory, microbiological and physical examinations were abstracted and compared with the data obtained in other regions.

RESULTS

Two of the three patients under our care developed SARS disease. This is characterised by fever of sudden onset lasting for more than 5 days, rapidly changing consolidations in chest x-ray not affected by antimicrobial therapy, leuko-, lympho- as well as thrombopenia with a compromised pulmonary function later in the course. Close contacts with SARS patients does not regularly result in full development of the disease. Secretion of a coronavirus could be detected in respiratory samples during the febrile phase and in feces for a longer time. It is still an open question whether bedrest and antibiotic prophylaxis by themselves or an additional administration of ribavirin and corticosteroids can improve the outcome.

CONCLUSION

SARS is a new and highly contagious lung disease. It is crucial to be able to recognize the clinical appearance and the diagnostic features of this disease at an early stage, in order to prevent a further dissemination of the disease.

Authors+Show Affiliations

Medizinische Klinik III/Infektiologie, Universitätsklinik Frankfurt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

12748900

Citation

Rickerts, V, et al. "[Clinical Presentation and Management of the Severe Acute Respiratory Syndrome (SARS)]." Deutsche Medizinische Wochenschrift (1946), vol. 128, no. 20, 2003, pp. 1109-14.
Rickerts V, Wolf T, Rottmann C, et al. [Clinical presentation and management of the severe acute respiratory syndrome (SARS)]. Dtsch Med Wochenschr. 2003;128(20):1109-14.
Rickerts, V., Wolf, T., Rottmann, C., Preiser, W., Drosten, C., Jakobi, V., Leong, H. N., & Brodt, H. R. (2003). [Clinical presentation and management of the severe acute respiratory syndrome (SARS)]. Deutsche Medizinische Wochenschrift (1946), 128(20), 1109-14.
Rickerts V, et al. [Clinical Presentation and Management of the Severe Acute Respiratory Syndrome (SARS)]. Dtsch Med Wochenschr. 2003 May 16;128(20):1109-14. PubMed PMID: 12748900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical presentation and management of the severe acute respiratory syndrome (SARS)]. AU - Rickerts,V, AU - Wolf,T, AU - Rottmann,C, AU - Preiser,W, AU - Drosten,C, AU - Jakobi,V, AU - Leong,H N, AU - Brodt,H R, PY - 2003/5/16/pubmed PY - 2003/6/18/medline PY - 2003/5/16/entrez SP - 1109 EP - 14 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 128 IS - 20 N2 - BACKGROUND AND OBJECTIVE: In February 2003, a newly emerged infectious disease was described, the etiology of which was initially unknown. It is referred to under the term SARS. In the beginning, it spread in some regions South-East Asia. Import infections appeared in many other parts of the world. Based on the first cases in Germany, this report illustrates the clinical appearance, the diagnostic results and the management of this new disease. PATIENTS AND METHODS: We analysed the data of two patients with SARS and one suspected patient. The results of radiological, laboratory, microbiological and physical examinations were abstracted and compared with the data obtained in other regions. RESULTS: Two of the three patients under our care developed SARS disease. This is characterised by fever of sudden onset lasting for more than 5 days, rapidly changing consolidations in chest x-ray not affected by antimicrobial therapy, leuko-, lympho- as well as thrombopenia with a compromised pulmonary function later in the course. Close contacts with SARS patients does not regularly result in full development of the disease. Secretion of a coronavirus could be detected in respiratory samples during the febrile phase and in feces for a longer time. It is still an open question whether bedrest and antibiotic prophylaxis by themselves or an additional administration of ribavirin and corticosteroids can improve the outcome. CONCLUSION: SARS is a new and highly contagious lung disease. It is crucial to be able to recognize the clinical appearance and the diagnostic features of this disease at an early stage, in order to prevent a further dissemination of the disease. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/12748900/[Clinical_presentation_and_management_of_the_severe_acute_respiratory_syndrome__SARS_]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-39253 DB - PRIME DP - Unbound Medicine ER -