Tags

Type your tag names separated by a space and hit enter

Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients.
Am J Hematol 2003; 73(2):87-96AJ

Abstract

The majority of ocular adnexal lymphomas (OAL) are primary marginal zone B-cell lymphomas (MALT lymphomas). The present study correlated the clinicopathological variables with the histologic subtypes by World Health Organization (WHO) classification with emphasis on MALT lymphomas in OALs of Koreans. There were 68 cases (31 males and 37 females), with a mean age of 45.9 years (range 7-89 years). Histologically, 61 MALT-type, 2 diffuse large B-cell (DLBCL), 2 mantle cell type (MCL), 1 anaplastic large-cell (ALCL), and 2 NK/T-cell lymphomas (NK/T-L) were counted among them. Fifty-seven were primary cases (P-OAL), and 11 were secondary cases (S-OAL). Nearly all P-OALs were MALT lymphomas (n = 56, 98%), with an exception of 1 MCL. Eleven S-OALs included 5 MALT type, 2 DLBCL, 1 ALCL, 1 MCL, and 2 NK/T-L. All MALT lymphoma patients were alive (n = 59) except for 2 after a mean duration of follow-up of 27.6 months (range: 0-108 months): one died of an unrelated cause and one died of recurrence. One non-MALT type P-OAL was alive with no evidence of disease (42 months). Of the 11 S-OAL, 4 had marrow involvement and 5 had progression or relapse outside the orbit. Compared with the other subtypes, MALT lymphoma was more likely to present with local disease (P = 0.001), achieve complete remission (CR) (0.022), and be alive at last follow-up (0.197), and less likely to experience recurrence (P = 0.06). In conclusion, OALs in Koreans are characterized by a preponderance of primary lymphomas over systemic lymphomas, striking predominance of MALT type lymphomas, and young age of occurrence. Histologic subtype by WHO classification has a significant correlation with the final outcome, with the most favorable outcome associated with OALs of the MALT type.

Authors+Show Affiliations

Department of Diagnostic Pathology, Asan Medical Center, University of Ulsan-College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12749009

Citation

Cho, Eun Yoon, et al. "Clinicopathologic Analysis of Ocular Adnexal Lymphomas: Extranodal Marginal Zone B-cell Lymphoma Constitutes the Vast Majority of Ocular Lymphomas Among Koreans and Affects Younger Patients." American Journal of Hematology, vol. 73, no. 2, 2003, pp. 87-96.
Cho EY, Han JJ, Ree HJ, et al. Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients. Am J Hematol. 2003;73(2):87-96.
Cho, E. Y., Han, J. J., Ree, H. J., Ko, Y. H., Kang, Y. K., Ahn, H. S., ... Huh, J. (2003). Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients. American Journal of Hematology, 73(2), pp. 87-96.
Cho EY, et al. Clinicopathologic Analysis of Ocular Adnexal Lymphomas: Extranodal Marginal Zone B-cell Lymphoma Constitutes the Vast Majority of Ocular Lymphomas Among Koreans and Affects Younger Patients. Am J Hematol. 2003;73(2):87-96. PubMed PMID: 12749009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients. AU - Cho,Eun Yoon, AU - Han,Jae Joon, AU - Ree,Howe Jung, AU - Ko,Young Hyeh, AU - Kang,Yoon-koo, AU - Ahn,Hyo Sook, AU - Ahn,Seung Do, AU - Park,Chan Jeoung, AU - Huh,Jooryung, PY - 2003/5/16/pubmed PY - 2003/6/21/medline PY - 2003/5/16/entrez SP - 87 EP - 96 JF - American journal of hematology JO - Am. J. Hematol. VL - 73 IS - 2 N2 - The majority of ocular adnexal lymphomas (OAL) are primary marginal zone B-cell lymphomas (MALT lymphomas). The present study correlated the clinicopathological variables with the histologic subtypes by World Health Organization (WHO) classification with emphasis on MALT lymphomas in OALs of Koreans. There were 68 cases (31 males and 37 females), with a mean age of 45.9 years (range 7-89 years). Histologically, 61 MALT-type, 2 diffuse large B-cell (DLBCL), 2 mantle cell type (MCL), 1 anaplastic large-cell (ALCL), and 2 NK/T-cell lymphomas (NK/T-L) were counted among them. Fifty-seven were primary cases (P-OAL), and 11 were secondary cases (S-OAL). Nearly all P-OALs were MALT lymphomas (n = 56, 98%), with an exception of 1 MCL. Eleven S-OALs included 5 MALT type, 2 DLBCL, 1 ALCL, 1 MCL, and 2 NK/T-L. All MALT lymphoma patients were alive (n = 59) except for 2 after a mean duration of follow-up of 27.6 months (range: 0-108 months): one died of an unrelated cause and one died of recurrence. One non-MALT type P-OAL was alive with no evidence of disease (42 months). Of the 11 S-OAL, 4 had marrow involvement and 5 had progression or relapse outside the orbit. Compared with the other subtypes, MALT lymphoma was more likely to present with local disease (P = 0.001), achieve complete remission (CR) (0.022), and be alive at last follow-up (0.197), and less likely to experience recurrence (P = 0.06). In conclusion, OALs in Koreans are characterized by a preponderance of primary lymphomas over systemic lymphomas, striking predominance of MALT type lymphomas, and young age of occurrence. Histologic subtype by WHO classification has a significant correlation with the final outcome, with the most favorable outcome associated with OALs of the MALT type. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/12749009/Clinicopathologic_analysis_of_ocular_adnexal_lymphomas:_extranodal_marginal_zone_b_cell_lymphoma_constitutes_the_vast_majority_of_ocular_lymphomas_among_Koreans_and_affects_younger_patients_ L2 - https://doi.org/10.1002/ajh.10332 DB - PRIME DP - Unbound Medicine ER -