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Plant peroxisomes, reactive oxygen metabolism and nitric oxide.
IUBMB Life. 2003 Feb; 55(2):71-81.IL

Abstract

In plant cells, as in most eukaryotic organisms, peroxisomes are probably the major sites of intracellular H2O2 production, as a result of their essentially oxidative type of metabolism. Like mitochondria and chloroplasts, peroxisomes also produce superoxide radicals (O2*-) and there are, at least, two sites of superoxide generation: one in the organelle matrix, the generating system being xanthine oxidase, and another site in the peroxisomal membranes dependent on NAD(P)H. In peroxisomal membranes, three integral polypeptides (PMPs) with molecular masses of 18, 29, and 32 kDa have been shown to generate O2*- radicals. Besides catalase, several antioxidative systems have been demonstrated in plant peroxisomes, including different superoxide dismutases, the four enzymes of the ascorbate-glutathione cycle plus ascorbate and glutathione, and three NADP-dependent dehydrogenases. A CuZn-SOD and two Mn-SODs have been purified and characterized from different types of plant peroxisomes. The presence of the enzyme nitric oxide synthase (NOS) and its reaction product, nitric oxide (NO*), has been recently demonstrated in plant peroxisomes. Different experimental evidence has suggested that peroxisomes have a ROS-mediated cellular function in leaf senescence and in stress situations induced by xenobiotics and heavy metals. Peroxisomes could also have a role in plant cells as a source of signal molecules like NO*, O2*- radicals, H2O2, and possibly S-nitrosoglutathione (GSNO). It seems reasonable to think that a signal molecule-producing function similar to that postulated for plant peroxisomes could also be performed by human, animal and yeast peroxisomes, where research on oxy radicals, antioxidants and nitric oxide is less advanced than in plant peroxisomes.

Authors+Show Affiliations

Departamento de Bioquímica, Biología Celular y Molecular de Plantas, Estación Experimental del Zaidín, CSIC, Apartado 419, E-18080 Granada, Spain. luisalfonso.delrio@eez.csic.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12749689

Citation

del Río, Luis A., et al. "Plant Peroxisomes, Reactive Oxygen Metabolism and Nitric Oxide." IUBMB Life, vol. 55, no. 2, 2003, pp. 71-81.
del Río LA, Corpas FJ, Sandalio LM, et al. Plant peroxisomes, reactive oxygen metabolism and nitric oxide. IUBMB Life. 2003;55(2):71-81.
del Río, L. A., Corpas, F. J., Sandalio, L. M., Palma, J. M., & Barroso, J. B. (2003). Plant peroxisomes, reactive oxygen metabolism and nitric oxide. IUBMB Life, 55(2), 71-81.
del Río LA, et al. Plant Peroxisomes, Reactive Oxygen Metabolism and Nitric Oxide. IUBMB Life. 2003;55(2):71-81. PubMed PMID: 12749689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant peroxisomes, reactive oxygen metabolism and nitric oxide. AU - del Río,Luis A, AU - Corpas,F Javier, AU - Sandalio,Luisa M, AU - Palma,José M, AU - Barroso,Juan B, PY - 2003/5/17/pubmed PY - 2004/1/6/medline PY - 2003/5/17/entrez SP - 71 EP - 81 JF - IUBMB life JO - IUBMB Life VL - 55 IS - 2 N2 - In plant cells, as in most eukaryotic organisms, peroxisomes are probably the major sites of intracellular H2O2 production, as a result of their essentially oxidative type of metabolism. Like mitochondria and chloroplasts, peroxisomes also produce superoxide radicals (O2*-) and there are, at least, two sites of superoxide generation: one in the organelle matrix, the generating system being xanthine oxidase, and another site in the peroxisomal membranes dependent on NAD(P)H. In peroxisomal membranes, three integral polypeptides (PMPs) with molecular masses of 18, 29, and 32 kDa have been shown to generate O2*- radicals. Besides catalase, several antioxidative systems have been demonstrated in plant peroxisomes, including different superoxide dismutases, the four enzymes of the ascorbate-glutathione cycle plus ascorbate and glutathione, and three NADP-dependent dehydrogenases. A CuZn-SOD and two Mn-SODs have been purified and characterized from different types of plant peroxisomes. The presence of the enzyme nitric oxide synthase (NOS) and its reaction product, nitric oxide (NO*), has been recently demonstrated in plant peroxisomes. Different experimental evidence has suggested that peroxisomes have a ROS-mediated cellular function in leaf senescence and in stress situations induced by xenobiotics and heavy metals. Peroxisomes could also have a role in plant cells as a source of signal molecules like NO*, O2*- radicals, H2O2, and possibly S-nitrosoglutathione (GSNO). It seems reasonable to think that a signal molecule-producing function similar to that postulated for plant peroxisomes could also be performed by human, animal and yeast peroxisomes, where research on oxy radicals, antioxidants and nitric oxide is less advanced than in plant peroxisomes. SN - 1521-6543 UR - https://www.unboundmedicine.com/medline/citation/12749689/Plant_peroxisomes_reactive_oxygen_metabolism_and_nitric_oxide_ L2 - https://doi.org/10.1080/1521654031000094694 DB - PRIME DP - Unbound Medicine ER -