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Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation.
Arterioscler Thromb Vasc Biol 2003; 23(7):1262-8AT

Abstract

OBJECTIVE

Because obesity and insulin resistance (IR) are strongly associated with liver steatosis (LS), we investigated the relation between the degree of LS and plasminogen activator inhibitor-1 (PAI-1) in ob/ob mice, in C57/BL6 mice with alcoholic LS, and in severely obese humans.

METHODS AND RESULTS

In both mouse models, plasma PAI-1 levels were associated with PAI-1 expression in the liver and with the degree of LS. Liver PAI-1 antigen was associated with the tumor necrosis factor receptor-II (TNFRII) antigen, whereas association with TNF antigen content was found in ob/ob mice only. No significant correlation between plasma PAI-1 and PAI-1 expression in adipose tissue of ob/ob mice was observed. Furthermore, the relation between plasma PAI-1 levels and body weight was positive in ob/ob mice but negative in C57/BL6 mice (both P<0.001). In humans, PAI-1 levels were correlated with the degree of LS, and 26% of plasma PAI-1 activity was independently explained by LS and serum insulin levels.

CONCLUSIONS

Plasma PAI-1 levels are more closely related to fat accumulation and PAI-1 expression in the liver than in adipose tissue. In steatotic liver, PAI-1 antigen content is associated with those of TNF and TNFRII. Therefore, we suggest that TNF pathway dysregulation in LS could be involved in increased plasma PAI-1 in obesity with IR.

Authors+Show Affiliations

Laboratoire d'Hématologie, EPI 99-36, 27, Faculty of Medicine, Bd Jean Moulin, 13385 Marseille Cedex 5, France. Marie-Christine.Alessi@medecine.univ-mrs.fr.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12750120

Citation

Alessi, Marie-Christine, et al. "Plasma PAI-1 Levels Are More Strongly Related to Liver Steatosis Than to Adipose Tissue Accumulation." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 7, 2003, pp. 1262-8.
Alessi MC, Bastelica D, Mavri A, et al. Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation. Arterioscler Thromb Vasc Biol. 2003;23(7):1262-8.
Alessi, M. C., Bastelica, D., Mavri, A., Morange, P., Berthet, B., Grino, M., & Juhan-Vague, I. (2003). Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(7), pp. 1262-8.
Alessi MC, et al. Plasma PAI-1 Levels Are More Strongly Related to Liver Steatosis Than to Adipose Tissue Accumulation. Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1262-8. PubMed PMID: 12750120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation. AU - Alessi,Marie-Christine, AU - Bastelica,Delphine, AU - Mavri,Alenka, AU - Morange,Pierre, AU - Berthet,Bruno, AU - Grino,Michel, AU - Juhan-Vague,Irene, Y1 - 2003/05/15/ PY - 2003/5/17/pubmed PY - 2004/2/6/medline PY - 2003/5/17/entrez SP - 1262 EP - 8 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 23 IS - 7 N2 - OBJECTIVE: Because obesity and insulin resistance (IR) are strongly associated with liver steatosis (LS), we investigated the relation between the degree of LS and plasminogen activator inhibitor-1 (PAI-1) in ob/ob mice, in C57/BL6 mice with alcoholic LS, and in severely obese humans. METHODS AND RESULTS: In both mouse models, plasma PAI-1 levels were associated with PAI-1 expression in the liver and with the degree of LS. Liver PAI-1 antigen was associated with the tumor necrosis factor receptor-II (TNFRII) antigen, whereas association with TNF antigen content was found in ob/ob mice only. No significant correlation between plasma PAI-1 and PAI-1 expression in adipose tissue of ob/ob mice was observed. Furthermore, the relation between plasma PAI-1 levels and body weight was positive in ob/ob mice but negative in C57/BL6 mice (both P<0.001). In humans, PAI-1 levels were correlated with the degree of LS, and 26% of plasma PAI-1 activity was independently explained by LS and serum insulin levels. CONCLUSIONS: Plasma PAI-1 levels are more closely related to fat accumulation and PAI-1 expression in the liver than in adipose tissue. In steatotic liver, PAI-1 antigen content is associated with those of TNF and TNFRII. Therefore, we suggest that TNF pathway dysregulation in LS could be involved in increased plasma PAI-1 in obesity with IR. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/12750120/Plasma_PAI_1_levels_are_more_strongly_related_to_liver_steatosis_than_to_adipose_tissue_accumulation_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000077401.36885.BB?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -