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Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study.

Abstract

Several studies have suggested that selenium may help to prevent colorectal neoplasia. To investigate the relation between prediagnostic serum selenium concentrations and colorectal adenomas, we conducted a nested case-control study using data from a large, multicenter, adenoma prevention trial. Cases comprised a total of 276 patients who developed a colorectal adenoma between the year 1 and year 4 follow-up exam. Controls were 276 patients who did not develop an adenoma during this time interval, matched to case subjects on age, sex, and clinical center. Total and bound selenium concentrations were measured from baseline or year 1 serum samples using instrumental neutron activation analysis. We estimated the odds ratios of colorectal adenoma in relation to serum selenium concentrations adjusting for age, clinical center, and sex. Compared with the lowest quintile, the odds ratio for the highest quintile was 0.76 (95% confidence interval, 0.44-1.30) for total selenium and 0.60 (95% confidence interval, 0.34-1.05) for bound selenium, and there was no apparent trend in risk (P for trend = 0.50 for total selenium and P for trend = 0.20 for bound selenium). Thus, our findings do not indicate a clear association between serum selenium concentrations and adenoma recurrence.

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  • Authors+Show Affiliations

    ,

    Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.

    , , , , , , ,

    Source

    MeSH

    Adenoma
    Case-Control Studies
    Colorectal Neoplasms
    Dietary Supplements
    Female
    Humans
    Male
    Middle Aged
    Neoplasm Recurrence, Local
    Randomized Controlled Trials as Topic
    Risk Factors
    Selenium
    United States

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12750244

    Citation

    Wallace, Kristin, et al. "Prediagnostic Serum Selenium Concentration and the Risk of Recurrent Colorectal Adenoma: a Nested Case-control Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 5, 2003, pp. 464-7.
    Wallace K, Byers T, Morris JS, et al. Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study. Cancer Epidemiol Biomarkers Prev. 2003;12(5):464-7.
    Wallace, K., Byers, T., Morris, J. S., Cole, B. F., Greenberg, E. R., Baron, J. A., ... Karagas, M. R. (2003). Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(5), pp. 464-7.
    Wallace K, et al. Prediagnostic Serum Selenium Concentration and the Risk of Recurrent Colorectal Adenoma: a Nested Case-control Study. Cancer Epidemiol Biomarkers Prev. 2003;12(5):464-7. PubMed PMID: 12750244.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study. AU - Wallace,Kristin, AU - Byers,Tim, AU - Morris,J Steven, AU - Cole,Bernard F, AU - Greenberg,E Robert, AU - Baron,John A, AU - Gudino,Alejandra, AU - Spate,Vickie, AU - Karagas,Margaret R, PY - 2003/5/17/pubmed PY - 2003/9/13/medline PY - 2003/5/17/entrez SP - 464 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 5 N2 - Several studies have suggested that selenium may help to prevent colorectal neoplasia. To investigate the relation between prediagnostic serum selenium concentrations and colorectal adenomas, we conducted a nested case-control study using data from a large, multicenter, adenoma prevention trial. Cases comprised a total of 276 patients who developed a colorectal adenoma between the year 1 and year 4 follow-up exam. Controls were 276 patients who did not develop an adenoma during this time interval, matched to case subjects on age, sex, and clinical center. Total and bound selenium concentrations were measured from baseline or year 1 serum samples using instrumental neutron activation analysis. We estimated the odds ratios of colorectal adenoma in relation to serum selenium concentrations adjusting for age, clinical center, and sex. Compared with the lowest quintile, the odds ratio for the highest quintile was 0.76 (95% confidence interval, 0.44-1.30) for total selenium and 0.60 (95% confidence interval, 0.34-1.05) for bound selenium, and there was no apparent trend in risk (P for trend = 0.50 for total selenium and P for trend = 0.20 for bound selenium). Thus, our findings do not indicate a clear association between serum selenium concentrations and adenoma recurrence. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12750244/Prediagnostic_serum_selenium_concentration_and_the_risk_of_recurrent_colorectal_adenoma:_a_nested_case_control_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12750244 DB - PRIME DP - Unbound Medicine ER -