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Gender difference in all-cause and cardiovascular mortality related to hyperglycaemia and newly-diagnosed diabetes.
Diabetologia. 2003 May; 46(5):608-17.D

Abstract

AIM/HYPOTHESIS

Diabetic women generally have a greater relative risk of cardiovascular diseases than diabetic men in comparison with non-diabetic women and men. Reasons for this excess risk in diabetic women is still unclear. The aim of this study is to evaluate whether the association between different degrees of hyperglycaemia and the risk of all-cause and cardiovascular mortality is different in women and men.

METHODS

We analysed baseline glucose concentrations from 14 prospective European cohorts including 8172 men and 9407 women aged 30 to 89 years without history of diabetes, with a median follow-up of 8.3 years. Hazards ratios for all-cause and cardiovascular mortality were estimated adjusting for other risk factors.

RESULTS

The mortality rates for all-cause and cardiovascular diseases were higher in men than in women in normoglycaemia, impaired glucose regulation and newly-diagnosed diabetes; the largest sex differential for cardiovascular mortality was in normoglycaemic people. The hazards ratios for all-cause and cardiovascular mortality were higher in newly-diagnosed diabetic women than men compared with normoglycaemic women and men, respectively; however, this sex difference was only significant for cardiovascular mortality. For smokers and for subjects with hypertension, hypercholesterolaemia or who where overweight, the hazards ratios for cardiovascular mortality in diabetic patients compared with normoglycaemic people were also higher in women than in men.

CONCLUSIONS/INTERPRETATION

Newly diagnosed diabetic women showed higher relative risks for death from cardiovascular disease than diabetic men. Thus a more aggressive control of hyperglycaemia as well as of other cardiovascular risk factors might be appropriate in women with asymptomatic hyperglycaemia.

Authors+Show Affiliations

Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland. hu.gang@ktl.fiNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12750769

Citation

Hu, G, and DECODE Study Group. "Gender Difference in All-cause and Cardiovascular Mortality Related to Hyperglycaemia and Newly-diagnosed Diabetes." Diabetologia, vol. 46, no. 5, 2003, pp. 608-17.
Hu G, DECODE Study Group. Gender difference in all-cause and cardiovascular mortality related to hyperglycaemia and newly-diagnosed diabetes. Diabetologia. 2003;46(5):608-17.
Hu, G. (2003). Gender difference in all-cause and cardiovascular mortality related to hyperglycaemia and newly-diagnosed diabetes. Diabetologia, 46(5), 608-17.
Hu G, DECODE Study Group. Gender Difference in All-cause and Cardiovascular Mortality Related to Hyperglycaemia and Newly-diagnosed Diabetes. Diabetologia. 2003;46(5):608-17. PubMed PMID: 12750769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender difference in all-cause and cardiovascular mortality related to hyperglycaemia and newly-diagnosed diabetes. AU - Hu,G, AU - ,, Y1 - 2003/05/15/ PY - 2002/11/25/received PY - 2003/01/10/revised PY - 2003/5/17/pubmed PY - 2004/3/31/medline PY - 2003/5/17/entrez SP - 608 EP - 17 JF - Diabetologia JO - Diabetologia VL - 46 IS - 5 N2 - AIM/HYPOTHESIS: Diabetic women generally have a greater relative risk of cardiovascular diseases than diabetic men in comparison with non-diabetic women and men. Reasons for this excess risk in diabetic women is still unclear. The aim of this study is to evaluate whether the association between different degrees of hyperglycaemia and the risk of all-cause and cardiovascular mortality is different in women and men. METHODS: We analysed baseline glucose concentrations from 14 prospective European cohorts including 8172 men and 9407 women aged 30 to 89 years without history of diabetes, with a median follow-up of 8.3 years. Hazards ratios for all-cause and cardiovascular mortality were estimated adjusting for other risk factors. RESULTS: The mortality rates for all-cause and cardiovascular diseases were higher in men than in women in normoglycaemia, impaired glucose regulation and newly-diagnosed diabetes; the largest sex differential for cardiovascular mortality was in normoglycaemic people. The hazards ratios for all-cause and cardiovascular mortality were higher in newly-diagnosed diabetic women than men compared with normoglycaemic women and men, respectively; however, this sex difference was only significant for cardiovascular mortality. For smokers and for subjects with hypertension, hypercholesterolaemia or who where overweight, the hazards ratios for cardiovascular mortality in diabetic patients compared with normoglycaemic people were also higher in women than in men. CONCLUSIONS/INTERPRETATION: Newly diagnosed diabetic women showed higher relative risks for death from cardiovascular disease than diabetic men. Thus a more aggressive control of hyperglycaemia as well as of other cardiovascular risk factors might be appropriate in women with asymptomatic hyperglycaemia. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/12750769/Gender_difference_in_all_cause_and_cardiovascular_mortality_related_to_hyperglycaemia_and_newly_diagnosed_diabetes_ L2 - https://doi.org/10.1007/s00125-003-1096-6 DB - PRIME DP - Unbound Medicine ER -