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Influence of leptin and the TNF system on insulin resistance in pregnancy and their effect on anthropometric parameters of newborns.
Acta Obstet Gynecol Scand. 2003 May; 82(5):432-8.AO

Abstract

BACKGROUND

We studied the contribution of the tumor necrosis factor system and leptin to insulin resistance during the course of normal pregnancy.

METHODS

Forty-five healthy pregnant women (15 in the 1st, 15 in the 2nd2 and 15 in the 3rd3 trimester) and 25 age-matched healthy nonpregnant women as controls. Twenty-three newborns delivered by women followed in the 2nd and 3rd trimesters were also investigated. Fasting serum immunoreactive tumor necrosis factor-alpha, soluble tumor necrosis factor receptor-1, soluble tumor necrosis factor receptor-2, leptin (by enzyme-linked immunoassay) and C-peptide (by radioimmunoassay) concentrations in the patients and controls were measured. Body weight, length and head circumference of the newborns were analyzed in connection with the measured maternal parameters.

RESULTS

Significantly elevated tumor necrosis factor-alpha, tumor necrosis factor receptor-1 and -2, leptin, and C-peptide levels were found in the 3rd3 trimester as compared with the 1st1 and 2nd2 trimesters and with the nonpregnant controls. Tumor necrosis factor-alpha, tumor necrosis factor receptor-2, C-peptide, leptin concentrations and body mass index were found to be in a significant positive linear correlation with each other. Significant negative linear correlations were calculated among maternal serum C-peptide, tumor necrosis factor-alpha and leptin concentrations and the head circumference of the newborns.

CONCLUSIONS

In conclusion, increased tumor necrosis factor-alpha and leptin levels may contribute to insulin resistance in late pregnancy. Tumor necrosis factor-alpha and leptin may be regulators of intrauterine bone development of newborns.

Authors+Show Affiliations

2nd Department of Obstetrics and Gynecology, Faculty of Medicine of Semmelweis University, Budapest, Hungary. melczer@noi2.sote.huNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12752073

Citation

Melczer, Zsolt, et al. "Influence of Leptin and the TNF System On Insulin Resistance in Pregnancy and Their Effect On Anthropometric Parameters of Newborns." Acta Obstetricia Et Gynecologica Scandinavica, vol. 82, no. 5, 2003, pp. 432-8.
Melczer Z, Bánhidy F, Csömör S, et al. Influence of leptin and the TNF system on insulin resistance in pregnancy and their effect on anthropometric parameters of newborns. Acta Obstet Gynecol Scand. 2003;82(5):432-8.
Melczer, Z., Bánhidy, F., Csömör, S., Tóth, P., Kovács, M., Winkler, G., & Cseh, K. (2003). Influence of leptin and the TNF system on insulin resistance in pregnancy and their effect on anthropometric parameters of newborns. Acta Obstetricia Et Gynecologica Scandinavica, 82(5), 432-8.
Melczer Z, et al. Influence of Leptin and the TNF System On Insulin Resistance in Pregnancy and Their Effect On Anthropometric Parameters of Newborns. Acta Obstet Gynecol Scand. 2003;82(5):432-8. PubMed PMID: 12752073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of leptin and the TNF system on insulin resistance in pregnancy and their effect on anthropometric parameters of newborns. AU - Melczer,Zsolt, AU - Bánhidy,Ferenc, AU - Csömör,Sándor, AU - Tóth,Péter, AU - Kovács,Margit, AU - Winkler,Gábor, AU - Cseh,Károly, PY - 2003/5/20/pubmed PY - 2003/7/9/medline PY - 2003/5/20/entrez SP - 432 EP - 8 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 82 IS - 5 N2 - BACKGROUND: We studied the contribution of the tumor necrosis factor system and leptin to insulin resistance during the course of normal pregnancy. METHODS: Forty-five healthy pregnant women (15 in the 1st, 15 in the 2nd2 and 15 in the 3rd3 trimester) and 25 age-matched healthy nonpregnant women as controls. Twenty-three newborns delivered by women followed in the 2nd and 3rd trimesters were also investigated. Fasting serum immunoreactive tumor necrosis factor-alpha, soluble tumor necrosis factor receptor-1, soluble tumor necrosis factor receptor-2, leptin (by enzyme-linked immunoassay) and C-peptide (by radioimmunoassay) concentrations in the patients and controls were measured. Body weight, length and head circumference of the newborns were analyzed in connection with the measured maternal parameters. RESULTS: Significantly elevated tumor necrosis factor-alpha, tumor necrosis factor receptor-1 and -2, leptin, and C-peptide levels were found in the 3rd3 trimester as compared with the 1st1 and 2nd2 trimesters and with the nonpregnant controls. Tumor necrosis factor-alpha, tumor necrosis factor receptor-2, C-peptide, leptin concentrations and body mass index were found to be in a significant positive linear correlation with each other. Significant negative linear correlations were calculated among maternal serum C-peptide, tumor necrosis factor-alpha and leptin concentrations and the head circumference of the newborns. CONCLUSIONS: In conclusion, increased tumor necrosis factor-alpha and leptin levels may contribute to insulin resistance in late pregnancy. Tumor necrosis factor-alpha and leptin may be regulators of intrauterine bone development of newborns. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/12752073/Influence_of_leptin_and_the_TNF_system_on_insulin_resistance_in_pregnancy_and_their_effect_on_anthropometric_parameters_of_newborns_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6349&date=2003&volume=82&issue=5&spage=432 DB - PRIME DP - Unbound Medicine ER -