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Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress.
Hum Exp Toxicol. 2003 Apr; 22(4):193-203.HE

Abstract

Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO3 (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, gamma-glutamyl transpeptidase, hydrogen peroxide and xanthine oxidase with reduction in the activities of renal antioxidant enzymes and renal glutathione content. A marked increase in blood urea nitrogen and serum creatinine has also been observed. KBrO3 treatment also enhances ornithine decarboxylase (ODC) activity and [3H] thymidine incorporation into renal DNA. Prophylaxis of rats orally with Nigella sativa extract (50 mg/kg body weight and 100 mg/kg body weight) resulted in a significant decrease in renal microsomal lipid peroxidation (P < 0.001), gamma-glutamyl transpeptidase (P < 0.001), H2O2 (P < 0.001) and xanthine oxidase (P < 0.05). There was significant recovery of renal glutathione content (P < 0.01) and antioxidant enzymes (P < 0.001). There was also reversal in the enhancement of blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Data suggest that Nigella sativa is a potent chemopreventive agent and may suppress KBrO3-mediated renal oxidative stress, toxicity and tumour promotion response in rats.

Authors+Show Affiliations

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi 110 062, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12755470

Citation

Khan, Naghma, et al. "Nigella Sativa (black Cumin) Ameliorates Potassium Bromate-induced Early Events of Carcinogenesis: Diminution of Oxidative Stress." Human & Experimental Toxicology, vol. 22, no. 4, 2003, pp. 193-203.
Khan N, Sharma S, Sultana S. Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress. Hum Exp Toxicol. 2003;22(4):193-203.
Khan, N., Sharma, S., & Sultana, S. (2003). Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress. Human & Experimental Toxicology, 22(4), 193-203.
Khan N, Sharma S, Sultana S. Nigella Sativa (black Cumin) Ameliorates Potassium Bromate-induced Early Events of Carcinogenesis: Diminution of Oxidative Stress. Hum Exp Toxicol. 2003;22(4):193-203. PubMed PMID: 12755470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress. AU - Khan,Naghma, AU - Sharma,Sonia, AU - Sultana,Sarwat, PY - 2003/5/21/pubmed PY - 2003/7/23/medline PY - 2003/5/21/entrez SP - 193 EP - 203 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 22 IS - 4 N2 - Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO3 (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, gamma-glutamyl transpeptidase, hydrogen peroxide and xanthine oxidase with reduction in the activities of renal antioxidant enzymes and renal glutathione content. A marked increase in blood urea nitrogen and serum creatinine has also been observed. KBrO3 treatment also enhances ornithine decarboxylase (ODC) activity and [3H] thymidine incorporation into renal DNA. Prophylaxis of rats orally with Nigella sativa extract (50 mg/kg body weight and 100 mg/kg body weight) resulted in a significant decrease in renal microsomal lipid peroxidation (P < 0.001), gamma-glutamyl transpeptidase (P < 0.001), H2O2 (P < 0.001) and xanthine oxidase (P < 0.05). There was significant recovery of renal glutathione content (P < 0.01) and antioxidant enzymes (P < 0.001). There was also reversal in the enhancement of blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Data suggest that Nigella sativa is a potent chemopreventive agent and may suppress KBrO3-mediated renal oxidative stress, toxicity and tumour promotion response in rats. SN - 0960-3271 UR - https://www.unboundmedicine.com/medline/citation/12755470/Nigella_sativa__black_cumin__ameliorates_potassium_bromate_induced_early_events_of_carcinogenesis:_diminution_of_oxidative_stress_ DB - PRIME DP - Unbound Medicine ER -