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Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption: a study of 30 patients.
Clin Lab Haematol. 2003 Jun; 25(3):161-6.CL

Abstract

BACKGROUND

It has been suggested that oral cobalamin (vitamin (B12)) therapy may be an effective therapy for treating cobalamin deficiencies related to food-cobalamin malabsorption. However, the duration of this treatment was not determined.

PATIENTS AND METHOD

In an open-label, nonplacebo study, we studied 30 patients with established cobalamin deficiency related to food-cobalamin malabsorption, who received between 250 and 1000 microg of oral crystalline cyanocobalamin per day for at least 1 month.

ENDPOINTS

Blood counts, serum cobalamin and homocysteine levels were determined at baseline and during the first month of treatment.

RESULTS

During the first month of treatment, 87% of the patients normalized their serum cobalamin levels; 100% increased their serum cobalamin levels (mean increase, +167 pg/dl; P < 0.001 compared with baseline); 100% had evidence of medullary regeneration; 100% corrected their initial macrocytosis; and 54% corrected their anemia. All patients had increased hemoglobin levels (mean increase, +0.6 g/dl) and reticulocyte counts (mean increase, +35 x 10(6)/l) and decreased erythrocyte cell volume (mean decrease, 3 fl; all P < 0.05).

CONCLUSION

Our findings suggest that crystalline cyanocobalamin, 250-1000 microg/day, given orally for 1 month, may be an effective treatment for cobalamin deficiencies not related to pernicious anemia.

Authors+Show Affiliations

Andrès E
Department of Internal Medicine, Diabetes and Metabolic Disorders, Hôpitaux Universitaires de Strasbourg, France. emmanuel.andres@chru-strasbourg.fr
Kaltenbach G
No affiliation info available
Noel E
No affiliation info available
Noblet-Dick M
No affiliation info available
Perrin AE
No affiliation info available
Vogel T
No affiliation info available
Schlienger JL
No affiliation info available
Berthel M
No affiliation info available
Blicklé JF
No affiliation info available

MeSH

AgedAged, 80 and overBlood Cell CountFemaleHemoglobinsHomocysteineHumansMalabsorption SyndromesMaleMiddle AgedTreatment OutcomeVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12755792

Citation

Andrès, E, et al. "Efficacy of Short-term Oral Cobalamin Therapy for the Treatment of Cobalamin Deficiencies Related to Food-cobalamin Malabsorption: a Study of 30 Patients." Clinical and Laboratory Haematology, vol. 25, no. 3, 2003, pp. 161-6.
Andrès E, Kaltenbach G, Noel E, et al. Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption: a study of 30 patients. Clin Lab Haematol. 2003;25(3):161-6.
Andrès, E., Kaltenbach, G., Noel, E., Noblet-Dick, M., Perrin, A. E., Vogel, T., Schlienger, J. L., Berthel, M., & Blicklé, J. F. (2003). Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption: a study of 30 patients. Clinical and Laboratory Haematology, 25(3), 161-6.
Andrès E, et al. Efficacy of Short-term Oral Cobalamin Therapy for the Treatment of Cobalamin Deficiencies Related to Food-cobalamin Malabsorption: a Study of 30 Patients. Clin Lab Haematol. 2003;25(3):161-6. PubMed PMID: 12755792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption: a study of 30 patients. AU - Andrès,E, AU - Kaltenbach,G, AU - Noel,E, AU - Noblet-Dick,M, AU - Perrin,A-E, AU - Vogel,T, AU - Schlienger,J-L, AU - Berthel,M, AU - Blicklé,J F, PY - 2003/5/21/pubmed PY - 2004/4/14/medline PY - 2003/5/21/entrez SP - 161 EP - 6 JF - Clinical and laboratory haematology JO - Clin Lab Haematol VL - 25 IS - 3 N2 - BACKGROUND: It has been suggested that oral cobalamin (vitamin (B12)) therapy may be an effective therapy for treating cobalamin deficiencies related to food-cobalamin malabsorption. However, the duration of this treatment was not determined. PATIENTS AND METHOD: In an open-label, nonplacebo study, we studied 30 patients with established cobalamin deficiency related to food-cobalamin malabsorption, who received between 250 and 1000 microg of oral crystalline cyanocobalamin per day for at least 1 month. ENDPOINTS: Blood counts, serum cobalamin and homocysteine levels were determined at baseline and during the first month of treatment. RESULTS: During the first month of treatment, 87% of the patients normalized their serum cobalamin levels; 100% increased their serum cobalamin levels (mean increase, +167 pg/dl; P < 0.001 compared with baseline); 100% had evidence of medullary regeneration; 100% corrected their initial macrocytosis; and 54% corrected their anemia. All patients had increased hemoglobin levels (mean increase, +0.6 g/dl) and reticulocyte counts (mean increase, +35 x 10(6)/l) and decreased erythrocyte cell volume (mean decrease, 3 fl; all P < 0.05). CONCLUSION: Our findings suggest that crystalline cyanocobalamin, 250-1000 microg/day, given orally for 1 month, may be an effective treatment for cobalamin deficiencies not related to pernicious anemia. SN - 0141-9854 UR - https://www.unboundmedicine.com/medline/citation/12755792/Efficacy_of_short_term_oral_cobalamin_therapy_for_the_treatment_of_cobalamin_deficiencies_related_to_food_cobalamin_malabsorption:_a_study_of_30_patients_ DB - PRIME DP - Unbound Medicine ER -