Tags

Type your tag names separated by a space and hit enter

Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment.
Arch Neurol 2003; 60(5):729-36AN

Abstract

BACKGROUND

Large numbers of neurofibrillary tangles (NFTs) and amyloid plaques are diagnostic markers for Alzheimer disease (AD), but lesser numbers of these lesions are also seen in nondemented elderly individuals. Much of the existing literature suggests that the NFTs of AD have a closer correlation with cognitive function than do amyloid plaques. Whether a similar relationship exists in normal aging and mild cognitive impairment (MCI), a condition that frequently reflects a preclinical stage of AD, remains unknown.

OBJECTIVE

To determine the distribution patterns of beta-amyloid plaques and NFTs and the association of these lesions with memory performance in nondemented individuals.

METHODS

We investigated regional distributions and neuropsychological correlates of NFTs and amyloid plaques in cognitively normal elderly persons and subjects with MCI who received neuropsychological testing before death. Subjects Eight nondemented subjects who volunteered to receive annual neuropsychological testing and agreed to brain donation were studied. Five subjects showed no cognitive impairment, and 3 were diagnosed with MCI.

RESULTS

Distribution of NFTs followed a rigorous and hierarchical pattern, but distribution of amyloid plaques varied among individuals. Subjects with MCI displayed higher NFT densities than did nonimpaired subjects. In addition, NFT density in the temporal lobe correlated with memory scores, whereas density of amyloid plaques did not.

CONCLUSIONS

Neurofibrillary tangles are more numerous in medial temporal lobe regions associated with memory function and show a relationship to performance on memory tests in nondemented individuals. These results suggest that NFTs may constitute a pathological substrate for memory loss not only in AD but also in normal aging and MCI.

Authors+Show Affiliations

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, IL 60611, USA. lgd450@nwu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12756137

Citation

Guillozet, Angela L., et al. "Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment." Archives of Neurology, vol. 60, no. 5, 2003, pp. 729-36.
Guillozet AL, Weintraub S, Mash DC, et al. Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol. 2003;60(5):729-36.
Guillozet, A. L., Weintraub, S., Mash, D. C., & Mesulam, M. M. (2003). Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Archives of Neurology, 60(5), pp. 729-36.
Guillozet AL, et al. Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment. Arch Neurol. 2003;60(5):729-36. PubMed PMID: 12756137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. AU - Guillozet,Angela L, AU - Weintraub,Sandra, AU - Mash,Deborah C, AU - Mesulam,M Marsel, PY - 2003/5/21/pubmed PY - 2003/6/13/medline PY - 2003/5/21/entrez SP - 729 EP - 36 JF - Archives of neurology JO - Arch. Neurol. VL - 60 IS - 5 N2 - BACKGROUND: Large numbers of neurofibrillary tangles (NFTs) and amyloid plaques are diagnostic markers for Alzheimer disease (AD), but lesser numbers of these lesions are also seen in nondemented elderly individuals. Much of the existing literature suggests that the NFTs of AD have a closer correlation with cognitive function than do amyloid plaques. Whether a similar relationship exists in normal aging and mild cognitive impairment (MCI), a condition that frequently reflects a preclinical stage of AD, remains unknown. OBJECTIVE: To determine the distribution patterns of beta-amyloid plaques and NFTs and the association of these lesions with memory performance in nondemented individuals. METHODS: We investigated regional distributions and neuropsychological correlates of NFTs and amyloid plaques in cognitively normal elderly persons and subjects with MCI who received neuropsychological testing before death. Subjects Eight nondemented subjects who volunteered to receive annual neuropsychological testing and agreed to brain donation were studied. Five subjects showed no cognitive impairment, and 3 were diagnosed with MCI. RESULTS: Distribution of NFTs followed a rigorous and hierarchical pattern, but distribution of amyloid plaques varied among individuals. Subjects with MCI displayed higher NFT densities than did nonimpaired subjects. In addition, NFT density in the temporal lobe correlated with memory scores, whereas density of amyloid plaques did not. CONCLUSIONS: Neurofibrillary tangles are more numerous in medial temporal lobe regions associated with memory function and show a relationship to performance on memory tests in nondemented individuals. These results suggest that NFTs may constitute a pathological substrate for memory loss not only in AD but also in normal aging and MCI. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/12756137/Neurofibrillary_tangles_amyloid_and_memory_in_aging_and_mild_cognitive_impairment_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/60/pg/729 DB - PRIME DP - Unbound Medicine ER -