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Red cell and plasma plant sterols are related during consumption of plant stanol and sterol ester spreads in children with hypercholesterolemia.
J Pediatr. 2003 May; 142(5):524-31.JPed

Abstract

OBJECTIVE

To show whether the ratios of squalene and cholesterol precursor sterols to cholesterol and cholestanol and plant sterols to cholesterol change differently in plasma and especially in the red cells of hypercholesterolemic children during consumption of plant stanol and sterol ester spreads.

STUDY DESIGN

In a randomized, double-blind, crossover study, hypercholesterolemic children (n = 23) consumed low-fat plant stanol and sterol ester spreads for 5-week periods separated by a 5-week washout period. Plasma and red cell lipids, squalene, and noncholesterol sterols were measured before and at the end of each period.

RESULTS

The plant stanol and sterol ester spreads lowered plasma total (-9% and -6%, respectively) and low-density lipoprotein (-12% and -9%) cholesterol but had no effect on red cell cholesterol, high-density lipoprotein cholesterol, or plasma triglycerides. The ratios of plasma and red cell sitosterol and campesterol to cholesterol decreased by 32% to 36% (P <.001) with the plant stanol ester and increased by 40% to 52% (P <.001) with the sterol ester spread.

CONCLUSIONS

Consumption of plant sterols increases and consumption of plant stanols decreases the ratios of plant sterols to cholesterol in red cells of hypercholesterolemic children proportionately to the respective changes in plasma.

Authors+Show Affiliations

Division of Internal Medicine, Department of Medicine, and the Hospital for Children and Adolescents, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12756385

Citation

Ketomäki, Anna M., et al. "Red Cell and Plasma Plant Sterols Are Related During Consumption of Plant Stanol and Sterol Ester Spreads in Children With Hypercholesterolemia." The Journal of Pediatrics, vol. 142, no. 5, 2003, pp. 524-31.
Ketomäki AM, Gylling H, Antikainen M, et al. Red cell and plasma plant sterols are related during consumption of plant stanol and sterol ester spreads in children with hypercholesterolemia. J Pediatr. 2003;142(5):524-31.
Ketomäki, A. M., Gylling, H., Antikainen, M., Siimes, M. A., & Miettinen, T. A. (2003). Red cell and plasma plant sterols are related during consumption of plant stanol and sterol ester spreads in children with hypercholesterolemia. The Journal of Pediatrics, 142(5), 524-31.
Ketomäki AM, et al. Red Cell and Plasma Plant Sterols Are Related During Consumption of Plant Stanol and Sterol Ester Spreads in Children With Hypercholesterolemia. J Pediatr. 2003;142(5):524-31. PubMed PMID: 12756385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red cell and plasma plant sterols are related during consumption of plant stanol and sterol ester spreads in children with hypercholesterolemia. AU - Ketomäki,Anna M, AU - Gylling,Helena, AU - Antikainen,Marjatta, AU - Siimes,Martti A, AU - Miettinen,Tatu A, PY - 2003/5/21/pubmed PY - 2003/7/8/medline PY - 2003/5/21/entrez SP - 524 EP - 31 JF - The Journal of pediatrics JO - J Pediatr VL - 142 IS - 5 N2 - OBJECTIVE: To show whether the ratios of squalene and cholesterol precursor sterols to cholesterol and cholestanol and plant sterols to cholesterol change differently in plasma and especially in the red cells of hypercholesterolemic children during consumption of plant stanol and sterol ester spreads. STUDY DESIGN: In a randomized, double-blind, crossover study, hypercholesterolemic children (n = 23) consumed low-fat plant stanol and sterol ester spreads for 5-week periods separated by a 5-week washout period. Plasma and red cell lipids, squalene, and noncholesterol sterols were measured before and at the end of each period. RESULTS: The plant stanol and sterol ester spreads lowered plasma total (-9% and -6%, respectively) and low-density lipoprotein (-12% and -9%) cholesterol but had no effect on red cell cholesterol, high-density lipoprotein cholesterol, or plasma triglycerides. The ratios of plasma and red cell sitosterol and campesterol to cholesterol decreased by 32% to 36% (P <.001) with the plant stanol ester and increased by 40% to 52% (P <.001) with the sterol ester spread. CONCLUSIONS: Consumption of plant sterols increases and consumption of plant stanols decreases the ratios of plant sterols to cholesterol in red cells of hypercholesterolemic children proportionately to the respective changes in plasma. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/12756385/Red_cell_and_plasma_plant_sterols_are_related_during_consumption_of_plant_stanol_and_sterol_ester_spreads_in_children_with_hypercholesterolemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(03)00119-7 DB - PRIME DP - Unbound Medicine ER -