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Septic shock secondary to scrub typhus: characteristics and complications.

Abstract

Scrub typhus is an acute febrile illness caused by infection with Orientia tsutsugamushi transmitted by the bite of larval trombiculid mites (chiggers). A prospective study was conducted in septic shock patients in Maharat Hospital, Nakhon Ratchasima Province, Thailand, from 12 November 2001 to 5 January 2002. Of the 51 septic shock patients studied during the 7 week period, 18 (35.3%) were found to have evidence of scrub typhus infection; 3 patients (16.7%) died. In this study, septic shock caused by Orientia tsutsugamushi is the most prominent (35.3%) in endemic area of scrub typhus. Scrub typhus with septic shock patients results in organ failure: respiratory failure, DIC were predominant, followed by renal and hepatic involvement. Two deaths were due to respiratory failure and one death was as a result of combined respiratory and renal failure. Fever was the most common symptom, followed by headache, myalgia and dyspnea; lymphadenophathy and eschar are common signs. Laboratory findings revealed that almost all of the patients had a mild leukocytosis, reduced hematocrit and thrombocytopenia; SGOT, ALP, direct bilirubin (DB), total billirubin (TB), BUN, Cr were elevated; hypoalbuminemia was noted. Urinalysis showed that 88.9% of the patients had albuminuria. 77.8% of patients had abnormal chest X-rays.

Authors+Show Affiliations

Malaria National Center, Phnom Penh, Cambodia. lonchanthap@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12757226

Citation

Thap, Lon Chan, et al. "Septic Shock Secondary to Scrub Typhus: Characteristics and Complications." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 33, no. 4, 2002, pp. 780-6.
Thap LC, Supanaranond W, Treeprasertsuk S, et al. Septic shock secondary to scrub typhus: characteristics and complications. Southeast Asian J Trop Med Public Health. 2002;33(4):780-6.
Thap, L. C., Supanaranond, W., Treeprasertsuk, S., Kitvatanachai, S., Chinprasatsak, S., & Phonrat, B. (2002). Septic shock secondary to scrub typhus: characteristics and complications. The Southeast Asian Journal of Tropical Medicine and Public Health, 33(4), 780-6.
Thap LC, et al. Septic Shock Secondary to Scrub Typhus: Characteristics and Complications. Southeast Asian J Trop Med Public Health. 2002;33(4):780-6. PubMed PMID: 12757226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Septic shock secondary to scrub typhus: characteristics and complications. AU - Thap,Lon Chan, AU - Supanaranond,Wichai, AU - Treeprasertsuk,Sombat, AU - Kitvatanachai,Sirima, AU - Chinprasatsak,Soontorn, AU - Phonrat,Benjaluck, PY - 2003/5/22/pubmed PY - 2003/8/13/medline PY - 2003/5/22/entrez SP - 780 EP - 6 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 33 IS - 4 N2 - Scrub typhus is an acute febrile illness caused by infection with Orientia tsutsugamushi transmitted by the bite of larval trombiculid mites (chiggers). A prospective study was conducted in septic shock patients in Maharat Hospital, Nakhon Ratchasima Province, Thailand, from 12 November 2001 to 5 January 2002. Of the 51 septic shock patients studied during the 7 week period, 18 (35.3%) were found to have evidence of scrub typhus infection; 3 patients (16.7%) died. In this study, septic shock caused by Orientia tsutsugamushi is the most prominent (35.3%) in endemic area of scrub typhus. Scrub typhus with septic shock patients results in organ failure: respiratory failure, DIC were predominant, followed by renal and hepatic involvement. Two deaths were due to respiratory failure and one death was as a result of combined respiratory and renal failure. Fever was the most common symptom, followed by headache, myalgia and dyspnea; lymphadenophathy and eschar are common signs. Laboratory findings revealed that almost all of the patients had a mild leukocytosis, reduced hematocrit and thrombocytopenia; SGOT, ALP, direct bilirubin (DB), total billirubin (TB), BUN, Cr were elevated; hypoalbuminemia was noted. Urinalysis showed that 88.9% of the patients had albuminuria. 77.8% of patients had abnormal chest X-rays. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/12757226/Septic_shock_secondary_to_scrub_typhus:_characteristics_and_complications_ L2 - https://ClinicalTrials.gov/search/term=12757226 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -