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Prevalence of West Nile virus infection in India.

Abstract

During the course of the virological investigation of cases of suspected viral fevers carried out at the National Institute of Virology (NIV), Pune, India, evidence of recent infection with West Nile (WN) virus was detected in 88 cases. Fever, general aches, headache, nausea and vomiting were the principal clinical features in 92% (81/88) of the cases; there were seven cases of encephalitis, in which WN virus-specific IgM class antibodies were detected in CSF samples. These cases of encephalitis were from Japanese encephalitis (JE) nonendemic areas, like Maharashtra and Rajasthan, as well as from JE endemic areas, like Goa and Orissa. Interestingly, neutralizing antibodies predominantly to WN virus were detected in CSF samples by the 50% cytopathic effect inhibition method; the titers ranged from 5 to 375. Cases of WN virus infection associated with both encephalitis and classic features have been reported for the first time in recent years in India. Reports of unique urban West Nile virus encephalitis epidemics in New York, Romania, and Algeria in recent years have signaled the emergence of neurological infection due to West Nile virus as a novel public health threat. This study is important because it records evidence of WN virus infection in India.

Authors+Show Affiliations

National Institute of Virology, Pune, Maharashtra, India. icmrniv@icmrniv.ren.nic.inNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12757229

Citation

Thakare, J P., et al. "Prevalence of West Nile Virus Infection in India." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 33, no. 4, 2002, pp. 801-5.
Thakare JP, Rao TL, Padbidri VS. Prevalence of West Nile virus infection in India. Southeast Asian J Trop Med Public Health. 2002;33(4):801-5.
Thakare, J. P., Rao, T. L., & Padbidri, V. S. (2002). Prevalence of West Nile virus infection in India. The Southeast Asian Journal of Tropical Medicine and Public Health, 33(4), 801-5.
Thakare JP, Rao TL, Padbidri VS. Prevalence of West Nile Virus Infection in India. Southeast Asian J Trop Med Public Health. 2002;33(4):801-5. PubMed PMID: 12757229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of West Nile virus infection in India. AU - Thakare,J P, AU - Rao,T L G, AU - Padbidri,V S, PY - 2003/5/22/pubmed PY - 2003/8/13/medline PY - 2003/5/22/entrez SP - 801 EP - 5 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 33 IS - 4 N2 - During the course of the virological investigation of cases of suspected viral fevers carried out at the National Institute of Virology (NIV), Pune, India, evidence of recent infection with West Nile (WN) virus was detected in 88 cases. Fever, general aches, headache, nausea and vomiting were the principal clinical features in 92% (81/88) of the cases; there were seven cases of encephalitis, in which WN virus-specific IgM class antibodies were detected in CSF samples. These cases of encephalitis were from Japanese encephalitis (JE) nonendemic areas, like Maharashtra and Rajasthan, as well as from JE endemic areas, like Goa and Orissa. Interestingly, neutralizing antibodies predominantly to WN virus were detected in CSF samples by the 50% cytopathic effect inhibition method; the titers ranged from 5 to 375. Cases of WN virus infection associated with both encephalitis and classic features have been reported for the first time in recent years in India. Reports of unique urban West Nile virus encephalitis epidemics in New York, Romania, and Algeria in recent years have signaled the emergence of neurological infection due to West Nile virus as a novel public health threat. This study is important because it records evidence of WN virus infection in India. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/12757229/Prevalence_of_West_Nile_virus_infection_in_India_ L2 - http://www.diseaseinfosearch.org/result/7474 DB - PRIME DP - Unbound Medicine ER -