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[Effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in the guinea pig].
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Feb; 36(1):18-21.ZE

Abstract

OBJECTIVE

To define the effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in guinea pigs.

METHODS

The animals involved in the study were exposed to 8 Hz infrasound at 135dB SPL for 90 minutes in a reverberant chamber. The sinusoidal pendular test (SPT), auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) were respectively detected pre-exposure and at 0(within 2 hrs), 2 and 5 day after exposure. The ultrastructures of the inner ear were observed by scanning electron microscopy.

RESULTS

The slow-phase velocity and the frequency of the vestibular nystagmus elicited by sinusoidal pendular test (SPT) declined slightly following infrasound exposure, but the changes were not significant (P > 0.05). No differences in the ABR thresholds, the latencies and the interval peak latencies of I, III, V waves were found between the normal and the experimental groups, and among experimental groups. The amplitudes of DPOAE at any frequency declined remarkably in all experimental groups. The ultrastructures of the inner ear were damaged to different extent.

CONCLUSION

Infrasound could transiently depress the excitability of the vestibular end-organs, decrease the function of OHC in the organ of Corti and cause damage to the inner ear of guinea pigs.

Authors+Show Affiliations

Feng B
Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of PLA, Beijing 100853, China. fbo@sina.com
Jiang S
No affiliation info available
Yang W
No affiliation info available
Han D
No affiliation info available
Zhang S
No affiliation info available

MeSH

AnimalsEar, InnerEvoked Potentials, AuditoryFemaleGuinea PigsHair Cells, AuditoryMaleMicroscopy, Electron, ScanningOtoacoustic Emissions, SpontaneousSoundVestibule, LabyrinthVibration

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12761900

Citation

Feng, B, et al. "[Effects of Acute Infrasound Exposure On Vestibular and Auditory Functions and the Ultrastructural Changes of Inner Ear in the Guinea Pig]." Zhonghua Er Bi Yan Hou Ke Za Zhi, vol. 36, no. 1, 2001, pp. 18-21.
Feng B, Jiang S, Yang W, et al. [Effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in the guinea pig]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001;36(1):18-21.
Feng, B., Jiang, S., Yang, W., Han, D., & Zhang, S. (2001). [Effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in the guinea pig]. Zhonghua Er Bi Yan Hou Ke Za Zhi, 36(1), 18-21.
Feng B, et al. [Effects of Acute Infrasound Exposure On Vestibular and Auditory Functions and the Ultrastructural Changes of Inner Ear in the Guinea Pig]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001;36(1):18-21. PubMed PMID: 12761900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in the guinea pig]. AU - Feng,B, AU - Jiang,S, AU - Yang,W, AU - Han,D, AU - Zhang,S, PY - 2003/5/24/pubmed PY - 2004/3/5/medline PY - 2003/5/24/entrez SP - 18 EP - 21 JF - Zhonghua er bi yan hou ke za zhi JO - Zhonghua Er Bi Yan Hou Ke Za Zhi VL - 36 IS - 1 N2 - OBJECTIVE: To define the effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in guinea pigs. METHODS: The animals involved in the study were exposed to 8 Hz infrasound at 135dB SPL for 90 minutes in a reverberant chamber. The sinusoidal pendular test (SPT), auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) were respectively detected pre-exposure and at 0(within 2 hrs), 2 and 5 day after exposure. The ultrastructures of the inner ear were observed by scanning electron microscopy. RESULTS: The slow-phase velocity and the frequency of the vestibular nystagmus elicited by sinusoidal pendular test (SPT) declined slightly following infrasound exposure, but the changes were not significant (P > 0.05). No differences in the ABR thresholds, the latencies and the interval peak latencies of I, III, V waves were found between the normal and the experimental groups, and among experimental groups. The amplitudes of DPOAE at any frequency declined remarkably in all experimental groups. The ultrastructures of the inner ear were damaged to different extent. CONCLUSION: Infrasound could transiently depress the excitability of the vestibular end-organs, decrease the function of OHC in the organ of Corti and cause damage to the inner ear of guinea pigs. SN - 0412-3948 UR - https://www.unboundmedicine.com/medline/citation/12761900/[Effects_of_acute_infrasound_exposure_on_vestibular_and_auditory_functions_and_the_ultrastructural_changes_of_inner_ear_in_the_guinea_pig]_ DB - PRIME DP - Unbound Medicine ER -