Tags

Type your tag names separated by a space and hit enter

[Expression and significance of serum soluble tumor necrosis factor receptor-I in patients with head and neck neoplasm].
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Dec; 36(6):468-70.ZE

Abstract

OBJECTIVE

To investigate the expression and significance of serum soluble tumor necrosis factor receptor-I (sTNFR-I) in patients with head and neck neoplasms.

METHOD

The study was undertaken to detect serum sTNFR-I levels in 160 head neck cancer patients (including 12 cases of malignant lymphoma, 62 nasopharyngeal cancer, 56 laryngeal cancer, 22 hypopharyngeal cancer, 3 maxillary cancer and 5 thyrophyma), using Sandwich enzyme-linked immuno-sorbent assay.

RESULTS

The sTNFR-I levels were significantly higher in patients with carcinoma than those of healthy controls (P < 0.01). The sTNFR-I levels of malignant lymphoma and nasopharyngeal carcinoma were the highest among patients with head and neck neoplasm. The correlations between the serum sTNFR-I levels and the stages of head and neck neoplasms and other laboratory parameters were also analyzed and discussed.

CONCLUSION

The serum sTNFR-I levels may reflect the human immunity function, therefore it can be used as a helpful indicator to evaluate the therapeutic effect and monitor the relapses and metastasis of cancer.

Authors+Show Affiliations

Dong W
Department of Otorhinolaryngology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. dong weida@163.com
Xu J
No affiliation info available
Qiao Z
No affiliation info available
Wang N
No affiliation info available
Yu R
No affiliation info available

MeSH

AdolescentAdultAgedEnzyme-Linked Immunosorbent AssayFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedPrognosisReceptors, Tumor Necrosis Factor

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12761967

Citation

Dong, W, et al. "[Expression and Significance of Serum Soluble Tumor Necrosis Factor receptor-I in Patients With Head and Neck Neoplasm]." Zhonghua Er Bi Yan Hou Ke Za Zhi, vol. 36, no. 6, 2001, pp. 468-70.
Dong W, Xu J, Qiao Z, et al. [Expression and significance of serum soluble tumor necrosis factor receptor-I in patients with head and neck neoplasm]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001;36(6):468-70.
Dong, W., Xu, J., Qiao, Z., Wang, N., & Yu, R. (2001). [Expression and significance of serum soluble tumor necrosis factor receptor-I in patients with head and neck neoplasm]. Zhonghua Er Bi Yan Hou Ke Za Zhi, 36(6), 468-70.
Dong W, et al. [Expression and Significance of Serum Soluble Tumor Necrosis Factor receptor-I in Patients With Head and Neck Neoplasm]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001;36(6):468-70. PubMed PMID: 12761967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression and significance of serum soluble tumor necrosis factor receptor-I in patients with head and neck neoplasm]. AU - Dong,W, AU - Xu,J, AU - Qiao,Z, AU - Wang,N, AU - Yu,R, PY - 2003/5/24/pubmed PY - 2004/3/5/medline PY - 2003/5/24/entrez SP - 468 EP - 70 JF - Zhonghua er bi yan hou ke za zhi JO - Zhonghua Er Bi Yan Hou Ke Za Zhi VL - 36 IS - 6 N2 - OBJECTIVE: To investigate the expression and significance of serum soluble tumor necrosis factor receptor-I (sTNFR-I) in patients with head and neck neoplasms. METHOD: The study was undertaken to detect serum sTNFR-I levels in 160 head neck cancer patients (including 12 cases of malignant lymphoma, 62 nasopharyngeal cancer, 56 laryngeal cancer, 22 hypopharyngeal cancer, 3 maxillary cancer and 5 thyrophyma), using Sandwich enzyme-linked immuno-sorbent assay. RESULTS: The sTNFR-I levels were significantly higher in patients with carcinoma than those of healthy controls (P < 0.01). The sTNFR-I levels of malignant lymphoma and nasopharyngeal carcinoma were the highest among patients with head and neck neoplasm. The correlations between the serum sTNFR-I levels and the stages of head and neck neoplasms and other laboratory parameters were also analyzed and discussed. CONCLUSION: The serum sTNFR-I levels may reflect the human immunity function, therefore it can be used as a helpful indicator to evaluate the therapeutic effect and monitor the relapses and metastasis of cancer. SN - 0412-3948 UR - https://www.unboundmedicine.com/medline/citation/12761967/[Expression_and_significance_of_serum_soluble_tumor_necrosis_factor_receptor_I_in_patients_with_head_and_neck_neoplasm]_ DB - PRIME DP - Unbound Medicine ER -