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[Morphologic and functional abnormalities of the cardiovascular system in patients with hepatic cirrhosis].
Ital Heart J Suppl. 2003 Feb; 4(2):85-95.IH

Abstract

During liver cirrhosis many important changes occur in the cardiovascular system and these abnormalities appear more evident as portal hypertension and liver dysfunction progress. The cirrhotic heart develops a series of structural and functional abnormalities consisting in diastolic dysfunction and reduced myocardial reactivity during exercise, likely due to a diminished myocardial beta-adrenergic receptor function. Nevertheless, the peculiarity of the cardiovascular involvement during liver cirrhosis is represented by a progressive development of a hyperdynamic circulation that seems to be due to portal hypertension rather than to liver insufficiency. In fact, it has been hypothesized that this syndrome raise from the venous portal bed and is primarily determined by an increase in blood volume that leads to an enhanced cardiac output. Later, as liver cirrhosis progresses, new important pathogenetic elements occur and lead to a reduction in peripheral vascular resistances and to the full clinical expression of hyperdynamic circulation. The pathogenesis of hyperdynamic circulation is very interesting for scientific research because of the complex and still in part unknown origin. In addition, this syndrome has an important clinical meaning for its severely adverse prognostic value and it represents the pathogenetic background for a number of severe complications of advanced liver cirrhosis.

Authors+Show Affiliations

Cattedra di Cardiologia Università degli Studi Federico II Via S. Pansini, 5 80131 Napoli. piscione@unina.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ita

PubMed ID

12762257

Citation

Piscione, Federico, et al. "[Morphologic and Functional Abnormalities of the Cardiovascular System in Patients With Hepatic Cirrhosis]." Italian Heart Journal. Supplement : Official Journal of the Italian Federation of Cardiology, vol. 4, no. 2, 2003, pp. 85-95.
Piscione F, Manganiello V, Viola O, et al. [Morphologic and functional abnormalities of the cardiovascular system in patients with hepatic cirrhosis]. Ital Heart J Suppl. 2003;4(2):85-95.
Piscione, F., Manganiello, V., Viola, O., & Chiariello, M. (2003). [Morphologic and functional abnormalities of the cardiovascular system in patients with hepatic cirrhosis]. Italian Heart Journal. Supplement : Official Journal of the Italian Federation of Cardiology, 4(2), 85-95.
Piscione F, et al. [Morphologic and Functional Abnormalities of the Cardiovascular System in Patients With Hepatic Cirrhosis]. Ital Heart J Suppl. 2003;4(2):85-95. PubMed PMID: 12762257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Morphologic and functional abnormalities of the cardiovascular system in patients with hepatic cirrhosis]. AU - Piscione,Federico, AU - Manganiello,Vincenzo, AU - Viola,Orazio, AU - Chiariello,Massimo, PY - 2003/5/24/pubmed PY - 2003/6/6/medline PY - 2003/5/24/entrez SP - 85 EP - 95 JF - Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology JO - Ital Heart J Suppl VL - 4 IS - 2 N2 - During liver cirrhosis many important changes occur in the cardiovascular system and these abnormalities appear more evident as portal hypertension and liver dysfunction progress. The cirrhotic heart develops a series of structural and functional abnormalities consisting in diastolic dysfunction and reduced myocardial reactivity during exercise, likely due to a diminished myocardial beta-adrenergic receptor function. Nevertheless, the peculiarity of the cardiovascular involvement during liver cirrhosis is represented by a progressive development of a hyperdynamic circulation that seems to be due to portal hypertension rather than to liver insufficiency. In fact, it has been hypothesized that this syndrome raise from the venous portal bed and is primarily determined by an increase in blood volume that leads to an enhanced cardiac output. Later, as liver cirrhosis progresses, new important pathogenetic elements occur and lead to a reduction in peripheral vascular resistances and to the full clinical expression of hyperdynamic circulation. The pathogenesis of hyperdynamic circulation is very interesting for scientific research because of the complex and still in part unknown origin. In addition, this syndrome has an important clinical meaning for its severely adverse prognostic value and it represents the pathogenetic background for a number of severe complications of advanced liver cirrhosis. SN - 1129-4728 UR - https://www.unboundmedicine.com/medline/citation/12762257/[Morphologic_and_functional_abnormalities_of_the_cardiovascular_system_in_patients_with_hepatic_cirrhosis]_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -