Tags

Type your tag names separated by a space and hit enter

Improvement of iodine deficiency after iodine supplementation in schoolchildren of Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies.
J Endocrinol Invest 2003; 26(2 Suppl):43-8JE

Abstract

OBJECTIVE

In the mountainous areas of Azerbaijan the schoolchildren suffer from severe Iodine Deficiency (ID) with median Urinary iodine excretion (UIE) 36 mcg/l and prevalence of goiter 99% (estimated by US). In a population of 293,000 schoolchildren aged 8-14 y.o. we administered capsules containing 190 mg of iodized oil (Lipiodol-Guerbet, Cedex, France) twice yearly in 6 months apart (total 380 mg). The aim of the present study was to evaluate the efficacy, the benefits, as well as the possible side-effects in a follow-up period of 6 and 12 months after the initial administration of iodized oil.

METHODS

Six and 12 months after the initial administration of iodide, two representative samples of 391 and 326 children respectively were examined. The evaluation included: estimation of goiter by US, determination of UIE and serum measurements of T3, T4, TSH, Tg, autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg).

RESULTS

There was an improvement in median UIE which increased from 36 mcg/l to 68 and 81 mcg/l after 6 and 12 months of treatment respectively. The prevalence of goiter decreased from 99% to 54% and 26% respectively. Tg was decreased at 6 and 12 months from the first administration, whereas TSH remained unchanged at 6 months and decreased at 12 months when compared to the latter value. Hypothyroidism was detected in 7% of children after iodide administration both at 6 and 12 months, but overt hypothyroidism was observed only in 0.5% at 12 months. Subclinical hyperthyroidism was detected in 2% and 6% after iodide administration both at 6 and 12 months. There was a significant increase in the title of thyroid auto antibodies in 6 months which was retained and increased in 12 months. There was no relation between the appearance of thyroid dysfunction and the positive thyroid auto antibodies.

CONCLUSION

The dose of 190 mg iodide administered twice yearly, improved iodine deficiency and endemic goiter in schoolchildren. The increase of UIE resulted from iodide administration, was accompanied by an increased title of thyroid auto-antibodies and an increased prevalence of hyper- and hypothyrotropinemia apparently of no autoimmune etiology.

Authors+Show Affiliations

Department of Medicine, Division of Endocrinology, University of Patras Medical School, University Hospital, Patras, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12762640

Citation

Markou, K B., et al. "Improvement of Iodine Deficiency After Iodine Supplementation in Schoolchildren of Azerbaijan Was Accompanied By Hypo and Hyperthyrotropinemia and Increased Title of Thyroid Autoantibodies." Journal of Endocrinological Investigation, vol. 26, no. 2 Suppl, 2003, pp. 43-8.
Markou KB, Georgopoulos NA, Makri M, et al. Improvement of iodine deficiency after iodine supplementation in schoolchildren of Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies. J Endocrinol Invest. 2003;26(2 Suppl):43-8.
Markou, K. B., Georgopoulos, N. A., Makri, M., Vlasopoulou, B., Anastasiou, E., Vagenakis, G. A., ... Vagenakis, A. G. (2003). Improvement of iodine deficiency after iodine supplementation in schoolchildren of Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies. Journal of Endocrinological Investigation, 26(2 Suppl), pp. 43-8.
Markou KB, et al. Improvement of Iodine Deficiency After Iodine Supplementation in Schoolchildren of Azerbaijan Was Accompanied By Hypo and Hyperthyrotropinemia and Increased Title of Thyroid Autoantibodies. J Endocrinol Invest. 2003;26(2 Suppl):43-8. PubMed PMID: 12762640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of iodine deficiency after iodine supplementation in schoolchildren of Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies. AU - Markou,K B, AU - Georgopoulos,N A, AU - Makri,M, AU - Vlasopoulou,B, AU - Anastasiou,E, AU - Vagenakis,G A, AU - Kouloubi,K, AU - Theodosopoulos,N, AU - Lazarou,N, AU - Veizis,A, AU - Sakellaropoulos,G, AU - Vagenakis,A G, PY - 2003/5/24/pubmed PY - 2004/1/7/medline PY - 2003/5/24/entrez SP - 43 EP - 8 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 26 IS - 2 Suppl N2 - OBJECTIVE: In the mountainous areas of Azerbaijan the schoolchildren suffer from severe Iodine Deficiency (ID) with median Urinary iodine excretion (UIE) 36 mcg/l and prevalence of goiter 99% (estimated by US). In a population of 293,000 schoolchildren aged 8-14 y.o. we administered capsules containing 190 mg of iodized oil (Lipiodol-Guerbet, Cedex, France) twice yearly in 6 months apart (total 380 mg). The aim of the present study was to evaluate the efficacy, the benefits, as well as the possible side-effects in a follow-up period of 6 and 12 months after the initial administration of iodized oil. METHODS: Six and 12 months after the initial administration of iodide, two representative samples of 391 and 326 children respectively were examined. The evaluation included: estimation of goiter by US, determination of UIE and serum measurements of T3, T4, TSH, Tg, autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg). RESULTS: There was an improvement in median UIE which increased from 36 mcg/l to 68 and 81 mcg/l after 6 and 12 months of treatment respectively. The prevalence of goiter decreased from 99% to 54% and 26% respectively. Tg was decreased at 6 and 12 months from the first administration, whereas TSH remained unchanged at 6 months and decreased at 12 months when compared to the latter value. Hypothyroidism was detected in 7% of children after iodide administration both at 6 and 12 months, but overt hypothyroidism was observed only in 0.5% at 12 months. Subclinical hyperthyroidism was detected in 2% and 6% after iodide administration both at 6 and 12 months. There was a significant increase in the title of thyroid auto antibodies in 6 months which was retained and increased in 12 months. There was no relation between the appearance of thyroid dysfunction and the positive thyroid auto antibodies. CONCLUSION: The dose of 190 mg iodide administered twice yearly, improved iodine deficiency and endemic goiter in schoolchildren. The increase of UIE resulted from iodide administration, was accompanied by an increased title of thyroid auto-antibodies and an increased prevalence of hyper- and hypothyrotropinemia apparently of no autoimmune etiology. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/12762640/Improvement_of_iodine_deficiency_after_iodine_supplementation_in_schoolchildren_of_Azerbaijan_was_accompanied_by_hypo_and_hyperthyrotropinemia_and_increased_title_of_thyroid_autoantibodies_ DB - PRIME DP - Unbound Medicine ER -