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Mycosis fungoides with follicular mucinosis displaying aggressive tumor-stage transformation : successful treatment using radiation therapy plus oral bexarotene combination therapy.
Am J Clin Dermatol. 2003; 4(6):429-33.AJ

Abstract

Follicular mucinosis is a tissue reaction pattern characterized by mucin deposition with follicular sebaceous units and is found as an idiopathic, primary, benign process (alopecia mucinosa), or as a secondary process due to inflammatory and neoplastic disorders (mycosis fungoides). When associated with follicular mucinosis, mycosis fungoides commonly pursues an aggressive course, often undergoing large-cell transformation, which is associated with resistance to therapy and poor prognosis. We present a case of mycosis fungoides with follicular mucinosis that was treated with incomplete courses of interferon, isotretinoin, and polychemotherapy with subsequent rapid progression to tumor-stage mycosis fungoides with large cell transformation and nodal and bone marrow involvement. In this setting, the patient was treated with local radiation therapy, total-skin electron beam therapy, and therapy and maintenance with the oral retinoid-X-receptor retinoid bexarotene, and achieved a durable complete remission.

Authors+Show Affiliations

Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4095, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12762834

Citation

Apisarnthanarax, Narin, et al. "Mycosis Fungoides With Follicular Mucinosis Displaying Aggressive Tumor-stage Transformation : Successful Treatment Using Radiation Therapy Plus Oral Bexarotene Combination Therapy." American Journal of Clinical Dermatology, vol. 4, no. 6, 2003, pp. 429-33.
Apisarnthanarax N, Ha CS, Duvic M. Mycosis fungoides with follicular mucinosis displaying aggressive tumor-stage transformation : successful treatment using radiation therapy plus oral bexarotene combination therapy. Am J Clin Dermatol. 2003;4(6):429-33.
Apisarnthanarax, N., Ha, C. S., & Duvic, M. (2003). Mycosis fungoides with follicular mucinosis displaying aggressive tumor-stage transformation : successful treatment using radiation therapy plus oral bexarotene combination therapy. American Journal of Clinical Dermatology, 4(6), 429-33.
Apisarnthanarax N, Ha CS, Duvic M. Mycosis Fungoides With Follicular Mucinosis Displaying Aggressive Tumor-stage Transformation : Successful Treatment Using Radiation Therapy Plus Oral Bexarotene Combination Therapy. Am J Clin Dermatol. 2003;4(6):429-33. PubMed PMID: 12762834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mycosis fungoides with follicular mucinosis displaying aggressive tumor-stage transformation : successful treatment using radiation therapy plus oral bexarotene combination therapy. AU - Apisarnthanarax,Narin, AU - Ha,Chul S, AU - Duvic,Madeleine, PY - 2003/5/24/pubmed PY - 2003/10/29/medline PY - 2003/5/24/entrez SP - 429 EP - 33 JF - American journal of clinical dermatology JO - Am J Clin Dermatol VL - 4 IS - 6 N2 - Follicular mucinosis is a tissue reaction pattern characterized by mucin deposition with follicular sebaceous units and is found as an idiopathic, primary, benign process (alopecia mucinosa), or as a secondary process due to inflammatory and neoplastic disorders (mycosis fungoides). When associated with follicular mucinosis, mycosis fungoides commonly pursues an aggressive course, often undergoing large-cell transformation, which is associated with resistance to therapy and poor prognosis. We present a case of mycosis fungoides with follicular mucinosis that was treated with incomplete courses of interferon, isotretinoin, and polychemotherapy with subsequent rapid progression to tumor-stage mycosis fungoides with large cell transformation and nodal and bone marrow involvement. In this setting, the patient was treated with local radiation therapy, total-skin electron beam therapy, and therapy and maintenance with the oral retinoid-X-receptor retinoid bexarotene, and achieved a durable complete remission. SN - 1175-0561 UR - https://www.unboundmedicine.com/medline/citation/12762834/Mycosis_fungoides_with_follicular_mucinosis_displaying_aggressive_tumor_stage_transformation_:_successful_treatment_using_radiation_therapy_plus_oral_bexarotene_combination_therapy_ L2 - https://dx.doi.org/10.2165/00128071-200304060-00006 DB - PRIME DP - Unbound Medicine ER -