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Noninvasive ultrasound measurements of aortic intima-media thickness: implications for in vivo study of aortic wall stress.
J Vasc Surg 2003; 37(6):1270-6JV

Abstract

OBJECT

The abdominal aorta (AA) has a predilection for aneurysm formation. An etiologic factor may be underlying aortic wall stress. The purpose of this study was to examine whether the intima-media thickness (IMT) of the AA, as a surrogate to arterial wall thickness, can be measured noninvasively with satisfactory results to calculate circumferential wall stress, and to evaluate regional and gender differences in wall stress.

METHODS

Sixty-five middle-aged healthy subjects were examined with B-mode ultrasound to determine the diameter and IMT in the infrarenal AA, common carotid artery (CCA), common femoral artery (CFA), and popliteal artery (PA). Blood pressure was measured noninvasively in the brachial artery. Wall stress was calculated according to the law of LaPlace.

RESULTS

Intraobserver variability for the IMT in the AA showed a coefficient of variation of 11%. IMT was thickest in the AA compared with the CCA, CFA, and PA (P <.001). There was a gender difference in IMT in the CFA (P <.05) and PA (P <.01) but not in the AA. Greater wall stress was found in the AA than in the CCA (P <.001) and PA (P <.001), with men having greater wall stress in all studied arterial regions.

CONCLUSIONS

Aortic IMT can be satisfactorily studied in vivo with noninvasive B-mode ultrasound. There are gender differences in IMT and wall stress, and the largest wall stress is found in the AA in men, which might be important in aneurysm development.

Authors+Show Affiliations

Department of Medicine and Care, University of Linköping, Division of Vascular Surgery, Jönköping Hospital, Jönköping, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12764275

Citation

Astrand, Håkan, et al. "Noninvasive Ultrasound Measurements of Aortic Intima-media Thickness: Implications for in Vivo Study of Aortic Wall Stress." Journal of Vascular Surgery, vol. 37, no. 6, 2003, pp. 1270-6.
Astrand H, Sandgren T, Ahlgren AR, et al. Noninvasive ultrasound measurements of aortic intima-media thickness: implications for in vivo study of aortic wall stress. J Vasc Surg. 2003;37(6):1270-6.
Astrand, H., Sandgren, T., Ahlgren, A. R., & Länne, T. (2003). Noninvasive ultrasound measurements of aortic intima-media thickness: implications for in vivo study of aortic wall stress. Journal of Vascular Surgery, 37(6), pp. 1270-6.
Astrand H, et al. Noninvasive Ultrasound Measurements of Aortic Intima-media Thickness: Implications for in Vivo Study of Aortic Wall Stress. J Vasc Surg. 2003;37(6):1270-6. PubMed PMID: 12764275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Noninvasive ultrasound measurements of aortic intima-media thickness: implications for in vivo study of aortic wall stress. AU - Astrand,Håkan, AU - Sandgren,Thomas, AU - Ahlgren,Asa Rydén, AU - Länne,Toste, PY - 2003/5/24/pubmed PY - 2003/6/24/medline PY - 2003/5/24/entrez SP - 1270 EP - 6 JF - Journal of vascular surgery JO - J. Vasc. Surg. VL - 37 IS - 6 N2 - OBJECT: The abdominal aorta (AA) has a predilection for aneurysm formation. An etiologic factor may be underlying aortic wall stress. The purpose of this study was to examine whether the intima-media thickness (IMT) of the AA, as a surrogate to arterial wall thickness, can be measured noninvasively with satisfactory results to calculate circumferential wall stress, and to evaluate regional and gender differences in wall stress. METHODS: Sixty-five middle-aged healthy subjects were examined with B-mode ultrasound to determine the diameter and IMT in the infrarenal AA, common carotid artery (CCA), common femoral artery (CFA), and popliteal artery (PA). Blood pressure was measured noninvasively in the brachial artery. Wall stress was calculated according to the law of LaPlace. RESULTS: Intraobserver variability for the IMT in the AA showed a coefficient of variation of 11%. IMT was thickest in the AA compared with the CCA, CFA, and PA (P <.001). There was a gender difference in IMT in the CFA (P <.05) and PA (P <.01) but not in the AA. Greater wall stress was found in the AA than in the CCA (P <.001) and PA (P <.001), with men having greater wall stress in all studied arterial regions. CONCLUSIONS: Aortic IMT can be satisfactorily studied in vivo with noninvasive B-mode ultrasound. There are gender differences in IMT and wall stress, and the largest wall stress is found in the AA in men, which might be important in aneurysm development. SN - 0741-5214 UR - https://www.unboundmedicine.com/medline/citation/12764275/Noninvasive_ultrasound_measurements_of_aortic_intima_media_thickness:_implications_for_in_vivo_study_of_aortic_wall_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741521402753445 DB - PRIME DP - Unbound Medicine ER -