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Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers.
Alcohol Clin Exp Res. 2003 May; 27(5):780-6.AC

Abstract

BACKGROUND

Recent studies have implicated central nicotinic cholinergic receptor systems in the reinforcing properties of alcohol. In laboratory animals, mecamylamine, a central nicotinic receptor antagonist, reduces the consumption of and preference for alcohol. This study investigated the effect of mecamylamine on the subjective responses to alcohol in humans. It was hypothesized that mecamylamine (7.5 and 15 mg) would attenuate the stimulant-like subjective effects of alcohol (0.8 g/kg) and decrease the self-reported desire to consume additional alcohol beverages.

METHODS

Fourteen male and 13 female nonsmokers participated in 6 laboratory sessions. During each session, subjects received, in randomized order under double-blinded conditions, a capsule containing mecamylamine (7.5 or 15 mg) or placebo followed by a beverage containing alcohol (0.8 g/kg) or placebo. Physiologic and subjective-effect measures were taken at 30-min intervals for 2 hr after beverage consumption.

RESULTS

Mecamylamine attenuated the stimulant and euphoric effects of alcohol and reduced the self-reported desire to consume additional alcohol beverages. This effect was most pronounced in men, even though women exhibited greater physiologic reactions to mecamylamine.

CONCLUSIONS

These findings suggest that nicotinic cholinergic receptors are involved in mediating some of the stimulant-like effects of alcohol.

Authors+Show Affiliations

Department of Psychiatry, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12766622

Citation

Chi, Henry, and Harriet de Wit. "Mecamylamine Attenuates the Subjective Stimulant-like Effects of Alcohol in Social Drinkers." Alcoholism, Clinical and Experimental Research, vol. 27, no. 5, 2003, pp. 780-6.
Chi H, de Wit H. Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers. Alcohol Clin Exp Res. 2003;27(5):780-6.
Chi, H., & de Wit, H. (2003). Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers. Alcoholism, Clinical and Experimental Research, 27(5), 780-6.
Chi H, de Wit H. Mecamylamine Attenuates the Subjective Stimulant-like Effects of Alcohol in Social Drinkers. Alcohol Clin Exp Res. 2003;27(5):780-6. PubMed PMID: 12766622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers. AU - Chi,Henry, AU - de Wit,Harriet, PY - 2003/5/27/pubmed PY - 2003/8/30/medline PY - 2003/5/27/entrez SP - 780 EP - 6 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 27 IS - 5 N2 - BACKGROUND: Recent studies have implicated central nicotinic cholinergic receptor systems in the reinforcing properties of alcohol. In laboratory animals, mecamylamine, a central nicotinic receptor antagonist, reduces the consumption of and preference for alcohol. This study investigated the effect of mecamylamine on the subjective responses to alcohol in humans. It was hypothesized that mecamylamine (7.5 and 15 mg) would attenuate the stimulant-like subjective effects of alcohol (0.8 g/kg) and decrease the self-reported desire to consume additional alcohol beverages. METHODS: Fourteen male and 13 female nonsmokers participated in 6 laboratory sessions. During each session, subjects received, in randomized order under double-blinded conditions, a capsule containing mecamylamine (7.5 or 15 mg) or placebo followed by a beverage containing alcohol (0.8 g/kg) or placebo. Physiologic and subjective-effect measures were taken at 30-min intervals for 2 hr after beverage consumption. RESULTS: Mecamylamine attenuated the stimulant and euphoric effects of alcohol and reduced the self-reported desire to consume additional alcohol beverages. This effect was most pronounced in men, even though women exhibited greater physiologic reactions to mecamylamine. CONCLUSIONS: These findings suggest that nicotinic cholinergic receptors are involved in mediating some of the stimulant-like effects of alcohol. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/12766622/Mecamylamine_attenuates_the_subjective_stimulant_like_effects_of_alcohol_in_social_drinkers_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2003&volume=27&issue=5&spage=780 DB - PRIME DP - Unbound Medicine ER -