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Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history.
Alcohol Clin Exp Res. 2003 May; 27(5):795-803.AC

Abstract

BACKGROUND

Numerous studies have identified differences in subjective response to alcohol in subjects differentiated by family history of alcoholism. Results suggest that genetic influences on individual variation in subjective response to alcohol may be a mechanism for genetic effects on alcohol problems. However, direct evidence for genetic effects on subjective response to alcohol is very limited.

METHODS

In a sample of 99 adult twin pairs, we studied genetic influences on subjective intoxication after alcohol challenge. The twins ingested a standard dose of ethanol (0.70 g/kg for men/0.65 g/kg for women), and two measures of subjective response to alcohol were assessed.

RESULTS

Genetic effects on variation in subjective intoxication reported 1 hr after drinking were significant and substantial: heritability was 0.60 for a 22-item scale and 0.48 for a brief 2-item measure. Self-report measures of neuroticism, psychasthenia, hostility, and family problems shared significant genetic covariation with subjective intoxication. Achieved breath alcohol level, rate of change in breath alcohol on the descending limb, and individual drinking history all shared familial variation with subjective intoxication. No significant genetic effects for subjective intoxication were found 2 hr after drinking, but familial influences remained present, and many of the same personality, drinking history, and breath alcohol variables were predictive of intoxication.

CONCLUSIONS

Subjective response to alcohol is heritable, and genetic effects on subjective intoxication are partly shared with genetic effects on personality.

Authors+Show Affiliations

Department of Psychology, Purdue School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA. viken@indiana.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Twin Study

Language

eng

PubMed ID

12766624

Citation

Viken, Richard J., et al. "Subjective Intoxication in Response to Alcohol Challenge: Heritability and Covariation With Personality, Breath Alcohol Level, and Drinking History." Alcoholism, Clinical and Experimental Research, vol. 27, no. 5, 2003, pp. 795-803.
Viken RJ, Rose RJ, Morzorati SL, et al. Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. Alcohol Clin Exp Res. 2003;27(5):795-803.
Viken, R. J., Rose, R. J., Morzorati, S. L., Christian, J. C., & Li, T. K. (2003). Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. Alcoholism, Clinical and Experimental Research, 27(5), 795-803.
Viken RJ, et al. Subjective Intoxication in Response to Alcohol Challenge: Heritability and Covariation With Personality, Breath Alcohol Level, and Drinking History. Alcohol Clin Exp Res. 2003;27(5):795-803. PubMed PMID: 12766624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. AU - Viken,Richard J, AU - Rose,Richard J, AU - Morzorati,Sandra L, AU - Christian,Joe C, AU - Li,Ting-Kai, PY - 2003/5/27/pubmed PY - 2003/8/30/medline PY - 2003/5/27/entrez SP - 795 EP - 803 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 27 IS - 5 N2 - BACKGROUND: Numerous studies have identified differences in subjective response to alcohol in subjects differentiated by family history of alcoholism. Results suggest that genetic influences on individual variation in subjective response to alcohol may be a mechanism for genetic effects on alcohol problems. However, direct evidence for genetic effects on subjective response to alcohol is very limited. METHODS: In a sample of 99 adult twin pairs, we studied genetic influences on subjective intoxication after alcohol challenge. The twins ingested a standard dose of ethanol (0.70 g/kg for men/0.65 g/kg for women), and two measures of subjective response to alcohol were assessed. RESULTS: Genetic effects on variation in subjective intoxication reported 1 hr after drinking were significant and substantial: heritability was 0.60 for a 22-item scale and 0.48 for a brief 2-item measure. Self-report measures of neuroticism, psychasthenia, hostility, and family problems shared significant genetic covariation with subjective intoxication. Achieved breath alcohol level, rate of change in breath alcohol on the descending limb, and individual drinking history all shared familial variation with subjective intoxication. No significant genetic effects for subjective intoxication were found 2 hr after drinking, but familial influences remained present, and many of the same personality, drinking history, and breath alcohol variables were predictive of intoxication. CONCLUSIONS: Subjective response to alcohol is heritable, and genetic effects on subjective intoxication are partly shared with genetic effects on personality. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/12766624/Subjective_intoxication_in_response_to_alcohol_challenge:_heritability_and_covariation_with_personality_breath_alcohol_level_and_drinking_history_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2003&volume=27&issue=5&spage=795 DB - PRIME DP - Unbound Medicine ER -