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Homocysteine: a marker for cognitive performance? A longitudinal follow-up study.
J Nutr Health Aging 2003; 7(3):153-9JN

Abstract

The present prospective study investigated whether elevated total serum homocysteine concentration is a risk factor for cognitive decline. The outcomes were compared to the possible relation between cognition and vitamin B12 or folic acid. Cognitive performance of 144 normal aging individuals (aged 30-80 years) was tested at baseline and after six years of follow-up. Domains of cognitive function addressed were cognitive speed (Letter-Digit Coding test), attention and information processing (Stroop test) and verbal learning and memory (Word Learning Test Total; Delayed Recall). Serum concentrations of homocysteine, folic acid and vitamin B12 were determined. Serum concentrations of homocysteine correlated negatively with cognitive performance on the Word Learning tests at baseline, independent of age, sex, education level or folic acid concentration. Homocysteine concentration at baseline correlated negatively with cognitive performance on the Stroop and Word Learning tests during the whole six-year follow-up period. The folic acid concentration correlated to the Delayed Recall test at baseline only and no correlations were observed for vitamin B12. Thus, while a relation between vitamin B12 or folic acid and cognition was almost absent, elevated homocysteine concentrations were associated with prolonged lower cognitive performance in this normal aging population.

Authors+Show Affiliations

European Graduate School of Neuroscience (Euron), Universiteit Maastricht, The Netherlands. c.teunissen.cell@med.vu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12766792

Citation

Teunissen, C E., et al. "Homocysteine: a Marker for Cognitive Performance? a Longitudinal Follow-up Study." The Journal of Nutrition, Health & Aging, vol. 7, no. 3, 2003, pp. 153-9.
Teunissen CE, Blom AH, Van Boxtel MP, et al. Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. J Nutr Health Aging. 2003;7(3):153-9.
Teunissen, C. E., Blom, A. H., Van Boxtel, M. P., Bosma, H., de Bruijn, C., Jolles, J., ... de Vente, J. (2003). Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. The Journal of Nutrition, Health & Aging, 7(3), pp. 153-9.
Teunissen CE, et al. Homocysteine: a Marker for Cognitive Performance? a Longitudinal Follow-up Study. J Nutr Health Aging. 2003;7(3):153-9. PubMed PMID: 12766792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. AU - Teunissen,C E, AU - Blom,A Henk J, AU - Van Boxtel,M P J, AU - Bosma,H, AU - de Bruijn,C, AU - Jolles,J, AU - Wauters,B A, AU - Steinbusch,H W M, AU - de Vente,J, PY - 2003/5/27/pubmed PY - 2003/9/27/medline PY - 2003/5/27/entrez SP - 153 EP - 9 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 7 IS - 3 N2 - The present prospective study investigated whether elevated total serum homocysteine concentration is a risk factor for cognitive decline. The outcomes were compared to the possible relation between cognition and vitamin B12 or folic acid. Cognitive performance of 144 normal aging individuals (aged 30-80 years) was tested at baseline and after six years of follow-up. Domains of cognitive function addressed were cognitive speed (Letter-Digit Coding test), attention and information processing (Stroop test) and verbal learning and memory (Word Learning Test Total; Delayed Recall). Serum concentrations of homocysteine, folic acid and vitamin B12 were determined. Serum concentrations of homocysteine correlated negatively with cognitive performance on the Word Learning tests at baseline, independent of age, sex, education level or folic acid concentration. Homocysteine concentration at baseline correlated negatively with cognitive performance on the Stroop and Word Learning tests during the whole six-year follow-up period. The folic acid concentration correlated to the Delayed Recall test at baseline only and no correlations were observed for vitamin B12. Thus, while a relation between vitamin B12 or folic acid and cognition was almost absent, elevated homocysteine concentrations were associated with prolonged lower cognitive performance in this normal aging population. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/12766792/Homocysteine:_a_marker_for_cognitive_performance_A_longitudinal_follow_up_study_ DB - PRIME DP - Unbound Medicine ER -